Orexins, also referred to as Hypocretins, are produced by specialized neurons in the lateral hypothalamus, which project into many different regions of the brain. Orexin A (33 amino acids) and Orexin B (28 amino acids) are both produced from a single pre-pro-orexin polypeptide by a cascade of enzymatic reactions.
The orexin system is conserved in mammals, and plays a central role in regulating feeding, sleep/wake cycles, arousal, energy expenditure, reward seeking, cognition and stress responses. Defects in orexin signaling are involved in diet-induced obesity, diabetes, narcolepsy, panic anxiety disorder, depression and addiction.
Synaptic Systems offers 2 polyclonal Guinea pig antibodies against Orexin, on recognizing specifically Orexin A (cat. no. 389 004) and one Orexin A/B (cat. no. 389 104) which react with both forms. This antibodies display superior results in IHC and IHC-P (FFPE) applications and the Orexin A antibody is KO validated.
Indirect immunostaining of PFA fixed WT mouse brain section (hypothalamus) with Guinea pig anti-Orexin A (cat. no. 389 004, dilution 1:500 red).
Courtesy: Dana Mayer & Markus Fendt, Institute of Pharmacology and Toxicology, Magedeburg
Indirect immunostaining of PFA fixed KO mouse brain section (hypothalamus) with Guinea pig anti-Orexin A (cat. no. 389 004, dilution 1:500 red).
Courtesy: Dana Mayer & Markus Fendt, Institute of Pharmacology and Toxicology, Magedeburg
Indirect immunostaining of PFA fixed mouse brain section with Guinea pig anti-Orexin A (cat. no. 389 004, dilution 1:500; red). Nuclei have been visualized by DAPI staining (blue).
Indirect immunostaining of PFA fixed mouse brain section with Guinea pig anti-Orexin A (cat. no. 389 004, dilution 1:500; red). Nuclei have been visualized by DAPI staining (blue).
| Cat. No. | Product Description | Application | Quantity | Price | Cart |
|---|
| 452 005 | ACTH, Guinea pig, polyclonal, affinity purifiedaffinity | IHC IHC-P | 50 µg | $460.00 |   |
| 438 004 | CCK-8, Guinea pig, polyclonal, antiserumantiserum | ICC IHC IHC-P | 100 µl | $370.00 | |
| 414 004 | CGRP, Guinea pig, polyclonal, antiserumantiserum | IHC IHC-P iDISCO Clarity | 100 µl | $365.00 | |
| 259 002 | Chromogranin A, rabbit, polyclonal, antiserumantiserum | WB | 200 µl | $355.00 | |
| 259 003 | Chromogranin A, rabbit, polyclonal, affinity purifiedaffinity K.O. | WB ICC IHC IHC-P | 50 µg | $455.00 | |
| 259-0P | Chromogranin A, control proteincontrol protein | 100 µg | $105.00 | | |
| 259 103 | Chromogranin B, rabbit, polyclonal, affinity purifiedaffinity K.O. | WB ICC IHC IHC-P | 50 µg | $375.00 | |
| 259-1P | Chromogranin B, control proteincontrol protein | 100 µg | $105.00 | | |
| 446 004 | Galanin, Guinea pig, polyclonal, antiserumantiserum | ICC IHC IHC-P | 100 µl | $365.00 | |
| 468 003 | Ghrelin, rabbit, polyclonal, affinity purifiedaffinity | IHC IHC-P | 50 µg | $375.00 | |
| 460 003 | GIP, rabbit, polyclonal, affinity purifiedaffinity discontinued, replacement: 514 003 | IHC IHC-P | 50 µg | | |
| 514 003 | GIP, rabbit, polyclonal, affinity purifiedaffinity | IHC IHC-P | 50 µg | $375.00 | |
| 471 005 | GLP-1, Guinea pig, polyclonal, affinity purifiedaffinity | Dot blot IHC IHC-P | 50 µg | $460.00 | |
| 434 005 | Neuropeptide S, Guinea pig, polyclonal, affinity purifiedaffinity | IHC IHC-P | 50 µg | $460.00 | |
| 394 004 | Neuropeptide Y, Guinea pig, polyclonal, antiserumantiserum | ICC IHC IHC-P | 100 µl | $365.00 | |
