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Orexin A/B - 389 104

Neuropeptides regulating feeding, sleep, arousal, reward seeking and energy homeostasis
Polyclonal Guinea pig antiserum
Cat. No.: 389 104
Amount: 100 µl
Price: $350.00
Cat. No. 389 104 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Applications WB: not tested yet
IP: not tested yet
ICC: not tested yet
IHC: 1 : 500 gallery  
IHC-P/FFPE: 1 : 500 gallery  
Immunogen Synthetic peptide corresponding to AA 87 to 96 from mouse Orexin (UniProt Id: O55241)
Reactivity Reacts with: human, rat, mouse (O55241).
Other species not tested yet.
Specificity Recognizes Orexin A and Orexin B with minor cross-reactivity to the unprocessed precursor protein.
Data sheet 389_104.pdf
Cat. No.: 389 104
Quantity: 100 µl
Price: $350.00
Background
Orexins, also referred to as Hypocretins, are produced by specialized neurons in the lateral hypothalamus, which project to many different regions of the brain. Orexin A (33 amino acids) and Orexin B (28 amino acids) are both produced from a single pre-pro-orexin polypeptide by a cascade of enzymatic reactions. They operate via binding to two closely related G protein-coupled receptors called Orexin receptor 1 and 2 (OxR 1 and OxR 2). OxR 1 is selective for Orexin A whereas OxR 2 binds both peptides with similar affinity.
The orexin system is conserved in mammals, and plays a central role in regulating feeding, sleep/wake cycles, arousal, energy expenditure, reward seeking, cognition, and stress responses. Defects in orexin signaling are involved in diet-induced obesity, diabetes, narcolepsy, panic anxiety disorder, depression, and addiction.