|Cat. No. 446 004||100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.|
WB: not tested yet
IP: not tested yet
ICC: 1 : 500 gallery
IHC: 1 : 500 gallery
IHC-P/FFPE: 1 : 500 up to 1 : 2500 gallery
|Immunogen||Synthetic peptide corresponding to AA 33 to 61 from mouse Galanin (UniProt Id: P47212)|
Reacts with: mouse (P47212), rat (P10683).
Other species not tested yet.
|Specificity||The antibody is specific for galanin. It may crossreact with the unprocessed precursor protein and with galanin-like peptide due to sequence homology.|
Galanin, also referred to as Gal or Galn, is a 30 amino acid neuropeptide (29 in rodents) which was first isolated from porcine intestine in 1983 (1). It is synthesized as part of a larger propeptide which is proteolytically processed to release the mature neuropeptide. Galanin is highly conserved across species and has a widespread presence in the periphery and the central nervous system, including brain, spinal cord, and gastrointestinal tract. The effects of this neuropeptide are mediated through three G protein coupled galanin receptors (2, 3).
Galanin has been implicated in many biologically diverse functions including arousal/sleep regulation, nociception, cognition, feeding, reproduction, osmotic homeostasis, glucose metabolism, and regulation of mood (3, 4).
Several human diseases, including Alzheimer’s disease, epilepsy, diabetes mellitus and mood disorders like anxiety and depression are associated with the disturbance of the galaninergic system (2, 3).