Cat. No.: 414 004
Amount: 100 µl
|Cat. No. 414 004||
100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate.', $event)" style="cursor: help;">IHC-P: 1 : 1000 gallery
iDISCO is a fast and cost-effective sample preparation method for clearing, immunolabeling and volume imaging of large biological samples. The clearing is carried out by benzyl-ether treatment. For additional experimental details, please refer to the „Remarks“ section or visit https://idisco.info.', $event)" style="cursor: help;">iDISCO: yes
|Immunogen||Synthetic peptide corresponding to AA 100 to 119 from mouse Calcitonin gene-related peptide 1 (UniProt Id: Q99JA0)|
Reacts with: mouse (Q99JA0), rat (P01256), human (P06881), ape.
Other species not tested yet.
|Specificity||This antibody recognizes α-CGRP. It may crossreact with the unprocessed precursor protein and with β-CGRP due to sequence homology.|
Calcitonin gene-related peptide (CGRP) is a 37-amino acid peptide produced by alternative splicing of calcitonin gene transcripts. It is characterized by a six amino acid ring structure linked by a disulfide bridge and an amidated C-terminus.
CGRP is present in parafollicular cells (C-cells) of the thyroid and in central and peripheral nerves. It is a potent vasodilator and can function in the transmission of pain. It has a major role in migraine pathophysiology, and CGRP antibodies have been used successfully in immunoneutralization.