|Cat. No. 414 004||100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.|
IHC: 1 : 500 gallery
IHC-P/FFPE: 1 : 1000 gallery
|Immunogen||Synthetic peptide corresponding to AA 100 to 119 from mouse Calcitonin gene-related peptide 1 (UniProt Id: Q99JA0)|
Reacts with: mouse (Q99JA0), rat (P01256), human (P06881), ape.
Other species not tested yet.
|Specificity||This antibody recognizes α-CGRP. It may crossreact with the unprocessed precursor protein and with β-CGRP due to sequence homology.|
Calcitonin gene-related peptide (CGRP) is a 37-amino acid peptide produced by alternative splicing of calcitonin gene transcripts. It is characterized by a six amino acid ring structure linked by a disulfide bridge and an amidated C-terminus.
CGRP is present in parafollicular cells (C-cells) of the thyroid and in central and peripheral nerves. It is a potent vasodilator and can function in the transmission of pain. It has a major role in migraine pathophysiology, and CGRP antibodies have been used successfully in immunoneutralization.