Vasopressin, a peptide hormone also referred to as arginine-vasopressin (AVP) or antidiuretic hormone (ADH), plays an imortant role in many physiological processes. Vasopressin is a nine amino acid messenger, proteolytically processed from a 164 aa precursor mainly in the paraventricular nucleus of hypothalamus (PVN) and Supraoptic nucleus (SON). The peptide is secreted from the posterior pituitary gland in response to decreased arterial blood volume. Its main effect in the body are an increased reabsorption of water in the kidney and a vasoconstriction resulting in an increase of blood pressure. Some vasopressin is also released directly into the brain and is involved in cognition, social behavior, sexual motivation, pair-bonding and maternal behavior.
Synaptic Systems offers a guinea pig polyclonal anti-Vasopressin antibody (Polyclonal guinea pig antiserum) with excellent performance in IHC and IHC-P/FFPE applications.
Indirect immunostaining of PFA fixed mouse brain section (hypothalamus) with guinea pig anti-Vasopressin (cat. no. 403 004, dilution 1:500; red). Nuclei have been visualized by DAPI staining (blue).
Indirect immunostaining of PFA fixed paraffin embedded mouse brain section (hypothalamus) with guinea pig anti-Vasopressin (cat. no. 403 004, dilution 1:1000). DAB has been used as chromogen. Nuclei have been counterstained with haematoxylin (blue).
Hicks AI, Barad Z, Sobrero A, Lean G, Jacob-Tomas S, Yang J, Choe KY, Prager-Khoutorsky M
Journal of neuroendocrinology (2019): Effects of Salt Loading on the Organization of Microtubules in Rat Magnocellular Vasopressin Neurons. PMID: 31778225
Barad Z, Jacob-Tomas S, Sobrero A, Lean G, Hicks AI, Yang J, Choe KY, Prager-Khoutorsky M
eNeuro () 72: Unique Organization of Actin Cytoskeleton in Magnocellular Vasopressin Neurons in Normal Conditions and in Response to Salt-Loading. PMID: 32209611
