Vasopressin antibody - 403 004

Vasopressin, also referred to as arginine-vasopressin (AVP) or antidiuretic hormone (ADH), is a nine amino acid peptide hormone secreted from the posterior pituitary in response to reductions in plasma volume and increases in plasma osmolarity. It is proteolytically processed from a precursor protein that is mainly synthesized in neurons of the hypothalamus.
Along with its carrier protein, neurophysin 2, vasopressin is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. Its release increases the amount of solute-free water reabsorbed back into the circulation from the filtrate in the kidney tubules of the nephrons. Further, vasopressin causes vasoconstriction of peripheral vessels, which increases peripheral vascular resistance and raises arterial blood pressure.
Some vasopressin is also released directly into the brain and is involved in cognition, social behavior, sexual motivation, pair-bonding, and maternal behavior.
Mutations in the vasopressin gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI), which is characterised by persistant thirst, polydipsia and polyuria.