Microglia are the primary immune cells of the central nervous system. However, recent data indicate that microglia also contribute to diverse physiological and pathophysiological processes that extend beyond immune-related functions, e.g. brain development. Microglia are ontogenetically and functionally distinct from monocyte-derived macrophages that infiltrate the CNS under pathological conditions.
Synaptic Systems offers now new antibodies against TMEM119, also referred to as OBIF, a protein which is an excellent marker for microglia in the brain. In contrast to other established microglia-marker proteins, TMEM119 is in the CNS specific for microglia and cannot be found on macrophages.
Figure 1: TMEM119 cat. no. 400 002 IHC
Indirect immunostaining of PFA fixed paraffin embedded mouse brain sections with rabbit anti-TMEM119 (cat. no. 400 002, dilution 1:500) using DAB as chromogen. Nuclei have been visualized by haematoxylin staining (blue).
Courtesy: Dr. Susanne Krasemann, Institute for Neuropathology, UKE Hamburg
| Cat. No. | Product Description | Application | Quantity | Price | Cart |
|---|
| 400 002 | TMEM119, rabbit, polyclonal, antiserumantiserum mouse specific | IHC IHC-P | 200 µl | $360.00 |   |
| 400 003 | TMEM119, rabbit, polyclonal, affinity purifiedaffinity mouse specific | IHC IHC-P | 50 µg | $455.00 | |
| 400 004 | TMEM119, Guinea pig, polyclonal, antiserumantiserum K.D. mouse specific | IHC IHC-P IHC-Fr | 100 µl | $370.00 | |
| 400 006 | TMEM119, chicken, polyclonal, affinity purifiedaffinity discontinued, replacement: 400 009 mouse specific | IHC IHC-P | 50 µg | | |
| 400 008 | TMEM119, rabbit, monoclonal, recombinant IgGrecombinant IgG mouse specific | IHC IHC-P | 50 µg | $415.00 | |
| 400 009 | TMEM119, chicken, monoclonal, recombinant IgYrecombinant IgY mouse specific | IHC IHC-P | 50 µg | $415.00 | |
| 400 011 | TMEM119, mouse, monoclonal, purified IgG IgG mouse specific | IHC IHC-P | 100 µg | $430.00 | |
| 400 102 | TMEM119, rabbit, polyclonal, antiserumantiserum human specific | IHC-P | 200 µl | $355.00 | |
| 400 111 | TMEM119, mouse, monoclonal, purified IgG IgG human specific | IHC-P | 100 µg | $415.00 | |
| 400 121 | TMEM119, mouse, monoclonal, purified IgG IgG human specific | IHC-P | 100 µg | $415.00 | |
| 400 203 | TMEM119, rabbit, polyclonal, affinity purifiedaffinity | IHC | 50 µg | $375.00 | |
| 400 211 | TMEM119, mouse, monoclonal, purified IgG IgG rat specific | IHC IHC-P | 100 µg | $415.00 | |
| 400 308 | TMEM119, Guinea pig, monoclonal, recombinant IgGrecombinant IgG mouse specific | IHC IHC-P | 50 µg | $415.00 | |
