This new guinea pig recombinant antibody is specifically developed for TRIM46. The tripartite motif containing protein TRIM46, also referred to as TRIFIC, is a member of the C-I TRIM family, a subfamily of the RBCC (N-terminal RING finger/B-box/coiled coil)/TRIM superfamily. TRIM46 is a prominent marker for the axon initial segment (AIS) in the adult brain. By forming closely spaced parallel microtubule bundles, it plays a crucial role in the initial polarization of neuronal cells.
A unique compartment located at the base of axons, called the axon initial segment (see Fig. 3), separates the somatodendritic and axonal compartments. It has a key role in neuronal physiology as it defines the initiation site of action potentials and functions as the gatekeeper of axonal arborization (2).
| Cat. No. | Product Description | Application | Quantity | Price | Cart |
|---|
| 188 002 | MAP2, rabbit, polyclonal, antiserumantiserum | WB ICC IHC IHC-P | 200 µl | $360.00 |   |
| 266 008 | NeuN, rabbit, monoclonal, recombinant IgGrecombinant IgG | ICC IHC IHC-P | 50 µg | $415.00 | |
| 377 308 | TRIM46, Guinea pig, monoclonal, recombinant IgGrecombinant IgG K.O. | ICC IHC IHC-P | 50 µg | $415.00 | |
Quistgaard et al. 2021: Mind the Gap: Molecular Architecture of the Axon Initial Segment – From Fold Prediction to a Mechanistic Model of Function? PMID: 34303720
Leterrier and Dargent 2014: No Pasaran! Role of the axon initial segment in the regulation of protein transport and the maintenance of axonal identity PMID: 24239676
