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TRIM 46 antibody - 377 308

TRIM46 is involved in establishing neuronal polarity
Guinea pig monoclonal recombinant IgG
Cat. No.: 377 308
Amount: 50 µg
Price: $415.00
Cat. No. 377 308 50 µg purified recombinant IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications
 
WB: not tested yet
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 1000 up to 1 : 2000 gallery  
IHC-P/FFPE: 1 : 1000 gallery  
Clone Gp264D12
Subtype IgG2 (κ light chain)
Immunogen Recombinant protein corresponding to AA 1 to 561 from rat Trim46 (UniProt Id: A0A0G2JXN2)
Reactivity Reacts with: mouse (Q7TNM2), rat (A0A0G2JXN2).
Other species not tested yet.
Specificity Specific for TRIM 46
Remarks

This antibody is a chimeric antibody based on the monoclonal mouse antibody clone 264D12. The constant regions of the heavy and light chains have been replaced by Guinea pig specific sequences. Therefore, the antibody can be used with standard anti-Guinea pig secondary reagents. The antibody has been expressed in mammalian cells.

Data sheet 377_308.pdf
Cat. No.: 377 308
Amount: 50 µg
Price: $415.00
Background
The tripartite motif containing protein TRIM 46, also referred to as TRIFIC, is a member of the C-I TRIM family, a subfamily of the RBCC (N-terminal RING finger/B-box/coiled coil)/TRIM superfamily.
TRIM 46 localizes to newly specified axons and, at later stages, to the axon initial segment (AIS). By forming closely spaced parallel microtubule bundles it plays a crucial role in the initial polarization of neuronal cells.