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VIP - 443 005

A peptide hormone with neurotransmitter and neuromodulator functions
Polyclonal Guinea pig purified antibody
Cat. No.: 443 005
Amount: 100 µl
Price: $450.00
Cat. No. 443 005 100 µl specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O. Then aliquot and store at -20°C to -80°C until use.
Applications WB: not tested yet
IP: not tested yet
ICC: 1 : 100 gallery  
IHC: 1 : 100 gallery  
IHC-P/FFPE: 1 : 100 gallery  
Immunogen Synthetic peptide corresponding to AA 125 to 152 from mouse VIP (UniProt Id: P32648)
Reactivity Reacts with: mouse (P32648), rat (P01283), human (P01282).
Other species not tested yet.
Specificity The antibody is specific for VIP. It may crossreact with the precursor protein, but does not recognize the related neuropeptide PACAP.
Data sheet 443_005.pdf
Cat. No.: 443 005
Quantity: 100 µl
Price: $450.00
Background

VIP (Vasoactive intestinal peptide) is a 28 amino acid peptide hormone, a member of the secretin/glucagon superfamily, and evolutionarily well conserved. It is synthesized as part of a larger propeptide which is proteolytically processed to release bioactive VIP as well as two other neuropeptides.

VIP is expressed in gastrointestinal tissues and in the central and peripheral nervous system. It is released from neurons upon depolarization and is known to stimulate adenylyl cyclase.

In the brain, VIP acts as a neurotransmitter and is involved in rhythm generation in the suprachiasmatic nucleus, the regulation of neuroendocrine secretions in the hypothalamus and energy metabolism of glial cells.

Peripherally, VIP influences many functions including blood flow and cardiac output, smooth muscle activity, secretion in the digestive tract, gastric motility, bronchodilation and activity within the hypothalamic-pituitary-adrenal axis.

The Verner-Morrison or Watery Diarrhea Hypokalemia and Achlorhydria (WDHA) syndrome is a characteristic clinical syndrome associated with overproduction of VIP from endocrine tumors.