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GABA-A receptor alpha1 - 224-2P

Receptors mediating inhibitory neurotransmission
control peptide
Cat. No.: 224-2P
Amount: 100 µg
Price: 90.00 €
Cat. No. 224-2P 100 µg peptide, lyophilized. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Control peptides should be stored at -20°C when still lyophilized!
Immunogen Synthetic peptide corresponding to AA 28 to 43 from rat GABA-A receptor α1 (UniProt Id: P62813)
Recommended dilution Optimal concentrations should be determined by the end-user.
Matching antibodies 224 203, 224 204, 224 205, 224 211
Remarks

This control peptide consists of the synthetic peptide (aa 28-43) that has been used for immunization. It has been tested in preadsorption experiments and blocks efficiently and specifically the corresponding signal in Western blots. The amount of peptide needed for efficient blocking depends on the titer and on the affinity of the antibody to the antigen.

Data sheet 224-2p.pdf
Cat. No.: 224-2P
Quantity: 100 µg
Price: 90.00 €
Background

Gamma-aminobutyric acid type A (GABA-A) receptors mediate the majority of inhibitory neurotransmission in the brain. These receptor proteins are ligand gated chloride ion channels and consist of a pentameric combination of different subunits (alpha, beta, gamma, delta, epsilon and rho). The resulting heterogenous population of GABA-A receptor subtypes are expressed throughout the brain with specific cellular and subcellular expression patterns.

Protocols