Cat. No. 224 208AT488 |
50 µg purified recombinant IgG, lyophilized, fluorescence-labeled with
ATTO® 488.
Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Either add 1:1 (v/v) glycerol, then aliquot and store at -20°C until use, or store aliquots at -80°C without additives. Reconstitute immediately upon receipt! Avoid bright light when working with the antibody to minimize photo bleeching of the fluorescent dye. |
Applications | |
Label | ATTO 488 |
Clone | Rb53D3 |
Subtype | IgG1 (κ light chain) |
Immunogen | Synthetic peptide corresponding to AA 28 to 43 from rat GABA-A receptor α1 (UniProt Id: P62813) |
Reactivity |
Reacts with: mouse (P62812), rat (P62813). Other species not tested yet. |
Matching control protein/peptide | 224-2P |
Remarks |
This antibody is a chimeric antibody based on the monoclonal mouse antibody clone 53D3. The constant regions of the heavy and light chains have been replaced by rabbit specific sequences. |
Data sheet | 224_208at488.pdf |
Gamma-aminobutyric acid type A (GABA-A) receptors mediate the majority of inhibitory neurotransmission in the brain. These receptor proteins are ligand gated chloride ion channels and consist of a pentameric combination of different subunits (alpha, beta, gamma, delta, epsilon and rho). The resulting heterogenous population of GABA-A receptor subtypes are expressed throughout the brain with specific cellular and subcellular expression patterns.