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c-Fos - 226 013

A member of the transcription factor complex AP1
Polyclonal rabbit purified antibody
Cat. No.: 226 013
Amount: 100 µl
Price: $370.00
Cat. No. 226 013 100 µl specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O. Then aliquot and store at -20°C to -80°C until use.
Applications IHC-P/FFPE: 1 : 1000 gallery  
Immunogen Synthetic peptide corresponding to AA 2 to 17 from rat c-Fos (UniProt Id: P12841) coupled to KLH via the C-terminal cysteine.
Reactivity Reacts with: mouse (P01101), rat (P12841).
Other species not tested yet.
Specificity Specific for c-Fos.
Matching control protein/peptide 226-0P
Data sheet 226_013.pdf
Cat. No.: 226 013
Quantity: 100 µl
Price: $370.00
Background

The Fos gene family consists of 4 members: c-Fos, FosB, FosL1, and FosL2, also called Fos related antigen 1 and 2 (FRA1 and 2). These leucine zipper proteins can dimerize with proteins of the JUN family leading to the formation of the transcription factor complex AP1 (1).
The expression of Fos proteins is rapidly and transiently induced by different extracellular stimuli such as growth factors, cytokines, neurotransmitters, polypeptide hormones, stress (2).
In addition Fos proteins can be phosphorylated by ERK kinases modulating transcriptional activity, protein stability and localization (3). c-Fos is the homologue to the Finkel-Biskis-Jinkins (FBJ) murine osteosarcoma virus oncogene (4).