|Cat. No. 226 013||100 µl specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O. Then aliquot and store at -20°C to -80°C until use.|
|Applications||IHC-P/FFPE: 1 : 1000 gallery|
|Immunogen||Synthetic peptide corresponding to AA 2 to 17 from rat c-Fos (UniProt Id: P12841) coupled to KLH via the C-terminal cysteine.|
Reacts with: mouse (P01101), rat (P12841).
Other species not tested yet.
|Specificity||Specific for c-Fos.|
|Matching control protein/peptide||226-0P|
The Fos gene family consists of 4 members: c-Fos, FosB, FosL1, and FosL2, also called Fos related antigen 1 and 2 (FRA1 and 2). These leucine zipper proteins can dimerize with proteins of the JUN family leading to the formation of the transcription factor complex AP1 (1).
The expression of Fos proteins is rapidly and transiently induced by different extracellular stimuli such as growth factors, cytokines, neurotransmitters, polypeptide hormones, stress (2).
In addition Fos proteins can be phosphorylated by ERK kinases modulating transcriptional activity, protein stability and localization (3). c-Fos is the homologue to the Finkel-Biskis-Jinkins (FBJ) murine osteosarcoma virus oncogene (4).