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Monocarboxylate Transporter 4 - 356 405

Monocarboxylate transporters
Polyclonal Guinea pig purified antibody
Cat. No.: 356 405
Amount: 50 µg
Price: 450.00 €
Cat. No. 356 405 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 up to 1 : 2000 gallery  
IP: not tested yet
ICC: not tested yet
IHC: not tested yet
IHC-P/FFPE: 1 : 200 up to 1 : 1000 gallery  
Immunogen Synthetic peptide corresponding to AA 447 to 459 from rat Monocarboxylate transporter 4 (UniProt Id: O35910)
Reactivity Reacts with: rat (O35910), human (O15427), mouse (P57787).
Other species not tested yet.
Specificity Monocarboxylate transporter 4
Data sheet 356_405.pdf
Cat. No.: 356 405
Quantity: 50 µg
Price: 450.00 €
Background

The proton-linked transport of monocarboxylates across the plasma membrane plays a critical role in the metabolism and pH regulation of most cells. Fourteen different monocarboxylic acid transporters (MCTs) have been identified, so far. Only four of them (MCT 1-4) have been shown to actively transport the monocarboxylates pyruvate and lactate across the cell membrane.
MCT 1, also referrred to as Slc16 a1, and MCT 2 show differential expression in astrocyte subpopulations and blood vessels in the mammalian brain.
MCT4 is highly expressed in glycolytic cells, such as skeletal muscle fibers, astrocytes, leukocytes, chondrocytes, and some mammalian cell lineages.