|Cat. No. 356 405||50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.|
WB: 1 : 1000 up to 1 : 2000 gallery
IP: not tested yet
ICC: not tested yet
IHC: not tested yet
IHC-P/FFPE: 1 : 200 up to 1 : 1000 gallery
|Immunogen||Synthetic peptide corresponding to AA 447 to 459 from rat Monocarboxylate transporter 4 (UniProt Id: O35910)|
Reacts with: rat (O35910), human (O15427), mouse (P57787).
Other species not tested yet.
|Specificity||Monocarboxylate transporter 4|
The proton-linked transport of monocarboxylates across the plasma membrane plays a critical role in the metabolism and pH regulation of most cells. Fourteen different monocarboxylic acid transporters (MCTs) have been identified, so far. Only four of them (MCT 1-4) have been shown to actively transport the monocarboxylates pyruvate and lactate across the cell membrane.
MCT 1, also referrred to as Slc16 a1, and MCT 2 show differential expression in astrocyte subpopulations and blood vessels in the mammalian brain.
MCT4 is highly expressed in glycolytic cells, such as skeletal muscle fibers, astrocytes, leukocytes, chondrocytes, and some mammalian cell lineages.