Cat. No.: 218 411BT
Amount: 100 µg
Price:
$465.00
|
|
|
| Cat. No. 218 411BT |
100 µg purified IgG, lyophilized, labeled with Biotin.
Biotin is a small vitamin B complex molecule. Its small size minimizes interference with antibody binding sites and allows for efficient conjugation without compromising antibody functionality. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications |
IP: not tested yet ICC: not tested yet IHC: not recommended IHC-P: 1 : 100 up to 1 : 200 Antigen retrieval with formic acid is required. gallery ELISA: yes Suitable as detector antibody |
| Label | biotin |
| Clone | 67B8 |
| Subtype | IgG2a |
| Immunogen | Synthetic peptide corresponding to AA 33 to 38 from human Abeta38 (UniProt Id: P05067) |
| Reactivity |
Reacts with: human (P05067). Other species not tested yet. |
| Specificity | Specific for Abeta 38 |
| Data sheet | 218_411bt.pdf |
|
|
Amyloid deposits, also called plaques, of Alzheimer's patients consist of several protein components like the amyloid beta-peptides (Abeta, Aβ) 1-40/42/43 and additional C- and N-terminally modified fragments of Abeta as for instance Abeta pE3 and Abeta pE11.
An additional Abeta variant, Abeta 38, is more soluble compared to other Abeta species and is not found in plaques of sporadic Alzheimer´s cases. However, it is detected in the blood-vessel walls of a subset of patients with severe cerebral amyloid angiopathy. It especially accumulates in brains of patients carrying mutations in the Abeta coding region.
Cleavage of amyloid precursor protein APP by β- and γ- secretases results in the generation of the Aβ (βA4)peptide, whereas α-secretase cleaves within the Aβ sequence and prevents the formation of Abeta from APP.