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Abeta38 antibody - 218 411BT

Abeta peptides are major components of neuritic plaques in Alzheimer's disease
Mouse monoclonal purified IgG
Cat. No.: 218 411BT
Amount: 100 µg
Price: $465.00
Cat. No. 218 411BT 100 µg purified IgG, lyophilized, labeled with Biotin.

Biotin is a small vitamin B complex molecule. Its small size minimizes interference with antibody binding sites and allows for efficient conjugation without compromising antibody functionality.
Biotin conjugated antibodies can be easily detected with Avidin/Streptavidin based secondary detection systems.
The streptavidin-biotin bond is one of the strongest non-covalent biological bonds known.

Albumin was added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
WB: not tested yet
IP: not tested yet
ICC: not tested yet
IHC: not recommended
IHC-P: 1 : 100 up to 1 : 200 Antigen retrieval with formic acid is required. gallery  
ELISA: yes Suitable as detector antibody
Label biotin
Clone 67B8
Subtype IgG2a
Immunogen Synthetic peptide corresponding to AA 33 to 38 from human Abeta38 (UniProt Id: P05067)
Reactivity Reacts with: human (P05067).
Other species not tested yet.
Specificity Specific for Abeta 38
Data sheet 218_411bt.pdf
Cat. No.: 218 411BT
Amount: 100 µg
Price: $465.00

Amyloid deposits, also called plaques, of Alzheimer's patients consist of several protein components like the amyloid beta-peptides (Abeta, Aβ) 1-40/42/43 and additional C- and N-terminally modified fragments of Abeta as for instance Abeta pE3 and Abeta pE11.
An additional Abeta variant, Abeta 38, is more soluble compared to other Abeta species and is not found in plaques of sporadic Alzheimer´s cases. However, it is detected in the blood-vessel walls of a subset of patients with severe cerebral amyloid angiopathy. It especially accumulates in brains of patients carrying mutations in the Abeta coding region.
Cleavage of amyloid precursor protein APP by β- and γ- secretases results in the generation of the Aβ (βA4)peptide, whereas α-secretase cleaves within the Aβ sequence and prevents the formation of Abeta from APP.