Home|||||||Technical Support|

Arc - 156 004

A cytoskeleton-associated protein involved in neuronal plasticity
Polyclonal Guinea pig antiserum
Cat. No.: 156 004
Amount: 100 µl
Price: $350.00
Cat. No. 156 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 AP staining gallery  
IP: not recommended
ICC: not tested yet
IHC: 1 : 500      gallery  
IHC-P/FFPE: 1 : 500 up to 1 : 1000 gallery  
Immunogen Recombinant protein corresponding to AA 1 to 396 from mouse Arc (UniProt Id: Q9WV31)
Reactivity Reacts with: rat (Q63053), mouse (Q9WV31).
Other species not tested yet.
Specificity Specific for arc. K.O.
Matching control protein/peptide 156-0P
Remarks

This antibody is an alternative for the discontinued purified antibody cat. no. 156 005.

Data sheet 156_004.pdf

References for Arc - 156 004

Functionally Distinct Neuronal Ensembles within the Memory Engram.
Sun X, Bernstein MJ, Meng M, Rao S, Sørensen AT, Yao L, Zhang X, Anikeeva PO, Lin Y
Cell (2020) 1812: 410-423.e17. 156 004 IHC; tested species: mouse
Granule Cell Ensembles in Mouse Dentate Gyrus Rapidly Upregulate the Plasticity-Related Protein Synaptopodin after Exploration Behavior.
Paul MH, Choi M, Schlaudraff J, Deller T, Del Turco D
Cerebral cortex (New York, N.Y. : 1991) (2019) : . 156 004 IHC, EM; tested species: mouse
Variability in nicotine conditioned place preference, stress-induced reinstatement, and effects of guanfacine in male and female mice.
Lee AM, Calarco CA, McKee SA, Mineur YS, Picciotto MR
Genes, brain, and behavior (2019) : e12601. 156 004 IHC; tested species: mouse
Sleep loss disrupts Arc expression in dentate gyrus neurons.
Delorme JE, Kodoth V, Aton SJ
Neurobiology of learning and memory (2018) : . 156 004 IHC; tested species: mouse
Granule Cell Ensembles in Mouse Dentate Gyrus Rapidly Upregulate the Plasticity-Related Protein Synaptopodin after Exploration Behavior.
Paul MH, Choi M, Schlaudraff J, Deller T, Del Turco D
Cerebral cortex (New York, N.Y. : 1991) (2019) : . 156 004 IHC, EM; tested species: mouse
Cat. No.: 156 004
Quantity: 100 µl
Price: $350.00
Functionally Distinct Neuronal Ensembles within the Memory Engram.
Sun X, Bernstein MJ, Meng M, Rao S, Sørensen AT, Yao L, Zhang X, Anikeeva PO, Lin Y
Cell (2020) 1812: 410-423.e17. 156 004 IHC; tested species: mouse
Granule Cell Ensembles in Mouse Dentate Gyrus Rapidly Upregulate the Plasticity-Related Protein Synaptopodin after Exploration Behavior.
Paul MH, Choi M, Schlaudraff J, Deller T, Del Turco D
Cerebral cortex (New York, N.Y. : 1991) (2019) : . 156 004 IHC, EM; tested species: mouse
Variability in nicotine conditioned place preference, stress-induced reinstatement, and effects of guanfacine in male and female mice.
Lee AM, Calarco CA, McKee SA, Mineur YS, Picciotto MR
Genes, brain, and behavior (2019) : e12601. 156 004 IHC; tested species: mouse
Sleep loss disrupts Arc expression in dentate gyrus neurons.
Delorme JE, Kodoth V, Aton SJ
Neurobiology of learning and memory (2018) : . 156 004 IHC; tested species: mouse
Granule Cell Ensembles in Mouse Dentate Gyrus Rapidly Upregulate the Plasticity-Related Protein Synaptopodin after Exploration Behavior.
Paul MH, Choi M, Schlaudraff J, Deller T, Del Turco D
Cerebral cortex (New York, N.Y. : 1991) (2019) : . 156 004 IHC, EM; tested species: mouse
Background
Immediate-early genes (IEGs) are rapidely induced after patterned synaptic activity. Genes that are involved in this complex response code for transcription and growth factors, metabolic and signaling enzymes, small GTP binding proteins and structural proteins. Some of these proteins may play a crucial role in long term plasticity which is important for learning processes.
The activity regulated cytoskeleton associated protein Arc or Arg 3.1 is enriched in dendrites and colocalizes with F-Actin. Direct interaction of Arc with actin has also been demonstrated by biochemical studies.