Synaptic Systems

Cat. No.: 160 003

Amount: 50 µg

Price: $475.00

Cat. No. 160 003	50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H₂O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications	WB: 1 : 1000 (AP staining) gallery IP: yes ICC: 1 : 500 up to 1 : 1000 (see remarks) gallery IHC: 1 : 200 gallery IHC-P: 1 : 500 up to 1 : 1000 gallery ExM: yes DNA-PAINT: 1 : 500 iDISCO: yes ELISA: yes (see remarks) Western blot (WB); separation of proteins by PAGE and subsequent transfer to a membrane. Detection of target molecules is carried out with antibodies. Some antibodies require special sample preparation steps. For details, please refer to the “Remarks” section. Immunoprecipitation (IP); Immunoisolation or pulldown of a target molecule using an antibody. For details and product specific hints, please refer to the ”Remarks” section. Immunocytochemistry (ICC) on 4% PFA fixed cells. Immunoreactivity is usually revealed by fluorescence. Some antibodies require special fixation methods. For details, please refer to the “Remarks” section. Immunohistochemistry (IHC) on 4% PFA perfusion fixed tissue with 24h PFA post fixation. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Some antibodies require special fixation methods or antigen retrieval steps. For details, please refer to the ”Remarks” section. Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Expansion Microscopy (ExM) is a sample preparation and imaging method which employs a dense interconnected web of swellable polymer within a biological specimen. A significantly higher effective resolution can be achieved with a standard microscope setup. For additional experimental details, please refer to the Remarks section. In antibody-based DNA-PAINT (Point Accumulation in Nanoscale Topography), a short oligomeric docking strand is coupled to a specific antibody. The transient association of the fluorophore to the antibody is mediated by the pairing of a short fluorescently labeled complementary imager DNA strand. DNA-PAINT allows super-resolution imaging and the imaging of a huge number of antibodies on the same biological sample in a single multiplex experiment. For additional experimental details refer to the Remarks section. iDISCO is a fast and cost-effective sample preparation method for clearing, immunolabeling and volume imaging of large biological samples. The clearing is carried out by benzyl-ether treatment. For additional experimental details, please refer to the „Remarks“ section or visit https://idisco.info. Enzyme-linked immunosorbent assay (ELISA); a frequently employed method to quantify target-molecules in solution. The detection of some proteins requires special solubilization steps. For further information, please refer to the „Remarks“ section.
Immunogen	Recombinant protein corresponding to the N-terminal half of human Homer 1 (UniProt Id: Q86YM7)
Reactivity	Reacts with: human (Q86YM7), rat (Q9Z214), mouse (Q9Z2Y3). Other species not tested yet.
Specificity	Specific for Homer 1. Cross-reactivity of the serum to Homer 2 and 3 was removed by pre-adsorption with Homer 2 (aa 1 - 176) and Homer 3 (aa 1 - 177).
Matching control protein/peptide	160-0P
Remarks	ICC: PFA fixation is recommended. ELISA: Suitable as detector antibody for sandwich-ELISA with cat. no. 160 011 as capture antibody. The ELISA-protocol for membrane proteins is recommended.
Data sheet	160_003.pdf

References for Homer1 - 160 003

Development of MAPT S305 mutation human iPSC lines exhibiting elevated 4R tau expression and functional alterations in neurons and astrocytes.
Bowles KR, Pedicone C, Pugh DA, Oja LM, Sousa FH, Keavey LK, Fulton-Howard B, Weitzman SA, Liu Y, Chen JL, Disney MD, et al.
Cell reports (2024) 4312: 115013. 160 003 WB; tested species: human

Manipulation of DHPS activity affects dendritic morphology and expression of synaptic proteins in primary rat cortical neurons.
Cavalli P, Raffauf A, Passarella S, Helmuth M, Dieterich DC, Landgraf P
Frontiers in cellular neuroscience (2024) 18: 1465011. 160 003 WB, ICC; tested species: rat

Liprin-α proteins are master regulators of human presynapse assembly.
Marcó de la Cruz B, Campos J, Molinaro A, Xie X, Jin G, Wei Z, Acuna C, Sterky FH
Nature neuroscience (2024) : . 160 003 WB; tested species: human

Person-specific differences in ubiquitin-proteasome mediated proteostasis in human neurons.
Hsieh YC, Augur ZM, Arbery M, Ashour N, Barrett K, Pearse RV, Tio ES, Duong DM, Felsky D, De Jager PL, Bennett DA, et al.
Alzheimer's & dementia : the journal of the Alzheimer's Association (2024) : . 160 003 WB; tested species: human

High-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assembly.
Berryer MH, Rizki G, Nathanson A, Klein JA, Trendafilova D, Susco SG, Lam D, Messana A, Holton KM, Karhohs KW, Cimini BA, et al.
eLife (2023) 12: . 160 003 WB; tested species: human

Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice.
Monsorno K, Ginggen K, Ivanov A, Buckinx A, Lalive AL, Tchenio A, Benson S, Vendrell M, D'Alessandro A, Beule D, Pellerin L, et al.
Nature communications (2023) 141: 5749. 160 003 WB, IHC; tested species: mouse

Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus.
Lloyd BA, Han Y, Roth R, Zhang B, Aoto J
Nature communications (2023) 141: 4706. 160 003 WB; tested species: mouse

Developmental Pb exposure increases AD risk via altered intracellular Ca2+ homeostasis in hiPSC-derived cortical neurons.
Xie J, Wu S, Szadowski H, Min S, Yang Y, Bowman AB, Rochet JC, Freeman JL, Yuan C
The Journal of biological chemistry (2023) : 105023. 160 003 WB, ICC; tested species: human

Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity.
Hsieh YC, Negri J, He A, Pearse RV, Liu L, Duong DM, Chibnik LB, Bennett DA, Seyfried NT, Young-Pearse TL
Molecular neurodegeneration (2022) 171: 61. 160 003 WB, ICC; tested species: human

Defective lipid signalling caused by mutations in PIK3C2B underlies focal epilepsy.
Gozzelino L, Kochlamazashvili G, Baldassari S, Mackintosh AI, Licchetta L, Iovino E, Liu YC, Bennett CA, Bennett MF, Damiano JA, Zsurka G, et al.
Brain : a journal of neurology (2022) 1457: 2313-2331. 160 003 WB; tested species: mouse

Missense mutation of Fmr1 results in impaired AMPAR-mediated plasticity and socio-cognitive deficits in mice.
Prieto M, Folci A, Poupon G, Schiavi S, Buzzelli V, Pronot M, François U, Pousinha P, Lattuada N, Abelanet S, Castagnola S, et al.
Nature communications (2021) 121: 1557. 160 003 WB, ICC; tested species: mouse

Nrg1 haploinsufficiency alters inhibitory cortical circuits.
Navarro-Gonzalez C, Carceller H, Benito Vicente M, Serra I, Navarrete M, Domínguez-Canterla Y, Rodríguez-Prieto Á, González-Manteiga A, Fazzari P
Neurobiology of disease (2021) 157: 105442. 160 003 WB; tested species: mouse

Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice.
Yilmaz M, Yalcin E, Presumey J, Aw E, Ma M, Whelan CW, Stevens B, McCarroll SA, Carroll MC
Nature neuroscience (2021) 242: 214-224. 160 003 WB, IHC; tested species: mouse

Selective disruption of inhibitory synapses leading to neuronal hyperexcitability at an early stage of tau pathogenesis in a mouse model.
Shimojo M, Takuwa H, Takado Y, Tokunaga M, Tsukamoto S, Minatohara K, Ono M, Seki C, Maeda J, Urushihata T, Minamihisamatsu T, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 160 003 WB; tested species: mouse

Proteome dynamics during homeostatic scaling in cultured neurons.
Dörrbaum AR, Alvarez-Castelao B, Nassim-Assir B, Langer JD, Schuman EM
eLife (2020) 9: . 160 003 WB; tested species: rat

Latrophilin-2 and latrophilin-3 are redundantly essential for parallel-fiber synapse function in cerebellum.
Zhang RS, Liakath-Ali K, Südhof TC
eLife (2020) 9: . 160 003 WB, IHC; tested species: mouse

SETD5 Regulates Chromatin Methylation State and Preserves Global Transcriptional Fidelity during Brain Development and Neuronal Wiring.
Sessa A, Fagnocchi L, Mastrototaro G, Massimino L, Zaghi M, Indrigo M, Cattaneo S, Martini D, Gabellini C, Pucci C, Fasciani A, et al.
Neuron (2019) : . 160 003 WB; tested species: mouse

Fluoxetine Suppresses Glutamate- and GABA-Mediated Neurotransmission by Altering SNARE Complex.
Lazarevic V, Mantas I, Flais I, Svenningsson P
International journal of molecular sciences (2019) 2017: . 160 003 WB; tested species: rat

LRRK2 modifies α-syn pathology and spread in mouse models and human neurons.
Bieri G, Brahic M, Bousset L, Couthouis J, Kramer NJ, Ma R, Nakayama L, Monbureau M, Defensor E, Schüle B, Shamloo M, et al.
Acta neuropathologica (2019) : . 160 003 WB; tested species: mouse

Neuronal KIF5b deletion induces striatum-dependent locomotor impairments and defects in membrane presentation of dopamine D2 receptors.
Cromberg LE, Saez TMM, Otero MG, Tomasella E, Alloatti M, Damianich A, Devoto VP, Ferrario J, Gelman D, Rubinstein M, Falzone TL, et al.
Journal of neurochemistry (2019) : . 160 003 WB; tested species: human

Hippocampal Memory Recovery After Acute Stress: A Behavioral, Morphological and Molecular Study.
Aguayo FI, Tejos-Bravo M, Díaz-Véliz G, Pacheco A, García-Rojo G, Corrales W, Olave FA, Aliaga E, Ulloa JL, Avalos AM, Román-Albasini L, et al.
Frontiers in molecular neuroscience (2018) 11: 283. 160 003 WB; tested species: rat

Homer1a drives homeostatic scaling-down of excitatory synapses during sleep.
Diering GH, Nirujogi RS, Roth RH, Worley PF, Pandey A, Huganir RL
Science (New York, N.Y.) (2017) 3556324: 511-515. 160 003 WB, IP; tested species: mouse

Distinct Defects in Synaptic Differentiation of Neocortical Neurons in Response to Prenatal Valproate Exposure.
Iijima Y, Behr K, Iijima T, Biemans B, Bischofberger J, Scheiffele P
Scientific reports (2016) 6: 27400. 160 003 WB

How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs.
Acuna C, Liu X, Südhof TC
Neuron (2016) 914: 792-807. 160 003 WB

Homer is concentrated at the postsynaptic density and does not redistribute after acute synaptic stimulation.
Tao-Cheng JH, Thein S, Yang Y, Reese TS, Gallant PE
Neuroscience (2014) 266: 80-90. 160 003 WB, EM; tested species: rat

SAM68 regulates neuronal activity-dependent alternative splicing of neurexin-1.
Iijima T, Wu K, Witte H, Hanno-Iijima Y, Glatter T, Richard S, Scheiffele P
Cell (2011) 1477: 1601-14. 160 003 WB; tested species: mouse

A stem cell-based assay platform demonstrates alpha-synuclein dependent synaptic dysfunction in patient-derived cortical neurons.
White AJ, Clark KA, Alexander KD, Ramalingam N, Young-Pearse TL, Dettmer U, Selkoe DJ, Ho GPH
NPJ Parkinson's disease (2024) 101: 107. 160 003 ICC; tested species: human

Loss of GTF2I promotes neuronal apoptosis and synaptic reduction in human cellular models of neurodevelopment.
Adams JW, Vinokur A, de Souza JS, Austria C, Guerra BS, Herai RH, Wahlin KJ, Muotri AR
Cell reports (2024) 433: 113867. 160 003 ICC; tested species: human

Integrated staging of morphofunctional connectivity in neuronal cultures.
Verstraelen P, Verschuuren M, De Vos WH
STAR protocols (2024) 52: 102957. 160 003 ICC

Notch receptor-ligand binding facilitates extracellular vesicle-mediated neuron-to-neuron communication.
Wang YZ, Castillon CCM, Gebis KK, Bartom ET, d'Azzo A, Contractor A, Savas JN
Cell reports (2024) 432: 113680. 160 003 ICC; tested species: rat

Human microglial cells as a therapeutic target in a neurodevelopmental disease model.
Mesci P, LaRock CN, Jeziorski JJ, Nakashima H, Chermont N, Ferrasa A, Herai RH, Ozaki T, Saleh A, Snethlage CE, Sanchez S, et al.
Stem cell reports (2024) : . 160 003 ICC; tested species: mouse

Developmental neurotoxicity of PFOA exposure on hiPSC-derived cortical neurons.
Wu S, Xie J, Zhao H, Zhao X, Sánchez OF, Rochet JC, Freeman JL, Yuan C
Environment international (2024) 190: 108914. 160 003 ICC; tested species: human

Heterozygous knockout of Synaptotagmin13 phenocopies ALS features and TP53 activation in human motor neurons.
Lehmann J, Aly A, Steffke C, Fabbio L, Mayer V, Dikwella N, Halablab K, Roselli F, Seiffert S, Boeckers TM, Brenner D, et al.
Cell death & disease (2024) 158: 560. 160 003 ICC; tested species: human

Actomyosin-mediated inhibition of synaptic vesicle release under CB1R activation.
McFadden MH, Emeritt MB, Xu H, Cui Y, Leterrier C, Zala D, Venance L, Lenkei Z
Translational psychiatry (2024) 141: 335. 160 003 ICC; tested species: rat

The human milk component myo-inositol promotes neuronal connectivity.
Paquette AF, Carbone BE, Vogel S, Israel E, Maria SD, Patil NP, Sah S, Chowdhury D, Kondratiuk I, Labhart B, Morrow AL, et al.
Proceedings of the National Academy of Sciences of the United States of America (2023) 12030: e2221413120. 160 003 ICC, IHC; tested species: human,rat

A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer's disease.
Jones ME, Büchler J, Dufor T, Palomer E, Teo S, Martin-Flores N, Boroviak K, Metzakopian E, Gibb A, Salinas PC
Science advances (2023) 92: eabo7421. 160 003 ICC, IHC; tested species: mouse

Decoding transcriptomic signatures of Cysteine String Protein alpha-mediated synapse maintenance.
Wang N, Zhu B, Allnutt MA, Grijalva RM, Zhao H, Chandra SS
bioRxiv : the preprint server for biology (2023) : . 160 003 ICC; tested species: mouse

Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson's iPSC-dopamine neurons.
Beccano-Kelly DA, Cherubini M, Mousba Y, Cramb KML, Giussani S, Caiazza MC, Rai P, Vingill S, Bengoa-Vergniory N, Ng B, Corda G, et al.
iScience (2023) 267: 107044. 160 003 ICC; tested species: human

Microglial Expression of the Wnt Signaling Modulator DKK2 Differs between Human Alzheimer's Disease Brains and Mouse Neurodegeneration Models.
Aghaizu ND, Jolly S, Samra SK, Kalmar B, Craessaerts K, Greensmith L, Salinas PC, De Strooper B, Whiting PJ
eNeuro (2023) 101: . 160 003 ICC; tested species: rat

A Neuron, Microglia, and Astrocyte Triple Co-culture Model to Study Alzheimer's Disease.
Luchena C, Zuazo-Ibarra J, Valero J, Matute C, Alberdi E, Capetillo-Zarate E
Frontiers in aging neuroscience (2022) 14: 844534. 160 003 ICC; tested species: rat

Hippocampal dendritic spines express the RyR3 but not the RyR2 ryanodine receptor isoform.
Vega-Vásquez I, Lobos P, Toledo J, Adasme T, Paula-Lima A, Hidalgo C
Biochemical and biophysical research communications (2022) 633: 96-103. 160 003 ICC, ExM; tested species: rat

Deficiency of protocadherin 9 leads to reduction in positive emotional behaviour.
Uemura M, Furuse T, Yamada I, Kushida T, Abe T, Imai K, Nagao S, Kudoh M, Yoshizawa K, Tamura M, Kiyonari H, et al.
Scientific reports (2022) 121: 11933. 160 003 ICC; tested species: mouse

α-Synuclein induced cholesterol lowering increases tonic and reduces depolarization-evoked synaptic vesicle recycling and glutamate release.
Lazarevic V, Yang Y, Paslawski W, Svenningsson P
NPJ Parkinson's disease (2022) 81: 71. 160 003 ICC; tested species: mouse

A multimodal 3D neuro-microphysiological system with neurite-trapping microelectrodes.
Molina-Martínez B, Jentsch LV, Ersoy F, van der Moolen M, Donato S, Ness TV, Heutink P, Jones PD, Cesare P
Biofabrication (2022) 142: . 160 003 ICC; tested species: mouse

Long-Term Cultures of Spinal Cord Interneurons.
Vargova I, Kriska J, Kwok JCF, Fawcett JW, Jendelova P
Frontiers in cellular neuroscience (2022) 16: 827628. 160 003 ICC; tested species: mouse

Presynaptic activity and protein turnover are correlated at the single-synapse level.
Jähne S, Mikulasch F, Heuer HGH, Truckenbrodt S, Agüi-Gonzalez P, Grewe K, Vogts A, Rizzoli SO, Priesemann V
Cell reports (2021) 3411: 108841. 160 003 ICC; tested species: rat

Pharmacological reversal of synaptic and network pathology in human MECP2-KO neurons and cortical organoids.
Trujillo CA, Adams JW, Negraes PD, Carromeu C, Tejwani L, Acab A, Tsuda B, Thomas CA, Sodhi N, Fichter KM, Romero S, et al.
EMBO molecular medicine (2021) 131: e12523. 160 003 ICC; tested species: human

Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum.
Kuijpers M, Kochlamazashvili G, Stumpf A, Puchkov D, Swaminathan A, Lucht MT, Krause E, Maritzen T, Schmitz D, Haucke V
Neuron (2021) 1092: 299-313.e9. 160 003 ICC; tested species: mouse

Latrophilin GPCR signaling mediates synapse formation.
Sando R, Südhof TC
eLife (2021) 10: . 160 003 ICC; tested species: mouse

TRPV1 Antagonist Prevents Neonatal Sevoflurane-Induced Synaptic Abnormality and Cognitive Impairment in Mice Through Regulating the Src/Cofilin Signaling Pathway.
Liu Y, Yang H, Fu Y, Pan Z, Qiu F, Xu Y, Yang X, Chen Q, Ma D, Liu Z
Frontiers in cell and developmental biology (2021) 9: 684516. 160 003 ICC; tested species: mouse

Immunoprecipitation of Ribosome-Bound mRNAs from Astrocytic Perisynaptic Processes of the Mouse Hippocampus.
Mazaré N, Oudart M, Cheung G, Boulay AC, Cohen-Salmon M
STAR protocols (2020) 13: 100198. 160 003 ICC; tested species: mouse

Targeted Complement Inhibition at Synapses Prevents Microglial Synaptic Engulfment and Synapse Loss in Demyelinating Disease.
Werneburg S, Jung J, Kunjamma RB, Ha SK, Luciano NJ, Willis CM, Gao G, Biscola NP, Havton LA, Crocker SJ, Popko B, et al.
Immunity (2020) 521: 167-182.e7. 160 003 ICC; tested species: mouse

Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates.
Micali N, Kim SK, Diaz-Bustamante M, Stein-O'Brien G, Seo S, Shin JH, Rash BG, Ma S, Wang Y, Olivares NA, Arellano JI, et al.
Cell reports (2020) 315: 107599. 160 003 ICC; tested species: human

Auxiliary α2δ1 and α2δ3 Subunits of Calcium Channels Drive Excitatory and Inhibitory Neuronal Network Development.
Bikbaev A, Ciuraszkiewicz-Wojciech A, Heck J, Klatt O, Freund R, Mitlöhner J, Enrile Lacalle S, Sun M, Repetto D, Frischknecht R, Ablinger C, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 4025: 4824-4841. 160 003 ICC; tested species: rat

Proline-rich transmembrane protein 2 (PRRT2) regulates the actin cytoskeleton during synaptogenesis.
Savino E, Cervigni RI, Povolo M, Stefanetti A, Ferrante D, Valente P, Corradi A, Benfenati F, Guarnieri FC, Valtorta F
Cell death & disease (2020) 1110: 856. 160 003 ICC; tested species: mouse

CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic Vesicles.
Ivanova D, Imig C, Camacho M, Reinhold A, Guhathakurta D, Montenegro-Venegas C, Cousin MA, Gundelfinger ED, Rosenmund C, Cooper B, Fejtova A, et al.
Cell reports (2020) 307: 2444-2459.e7. 160 003 ICC; tested species: mouse

A Method to Visualize the Nanoscopic Morphology of Astrocytes In Vitro and In Situ.
Heller JP, Rusakov DA
Methods in molecular biology (Clifton, N.J.) (2019) 1938: 69-84. 160 003 ICC; tested species: rat

A practical guide to optimization in X10 expansion microscopy.
Truckenbrodt S, Sommer C, Rizzoli SO, Danzl JG
Nature protocols (2019) : . 160 003 ICC; tested species: rat

Synaptic neurexin-1 assembles into dynamically regulated active zone nanoclusters.
Trotter JH, Hao J, Maxeiner S, Tsetsenis T, Liu Z, Zhuang X, Südhof TC
The Journal of cell biology (2019) : . 160 003 ICC; tested species: mouse

Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs. isogenic control.
Ghatak S, Dolatabadi N, Trudler D, Zhang X, Wu Y, Mohata M, Ambasudhan R, Talantova M, Lipton SA
eLife (2019) 8: . 160 003 ICC; tested species: human

Reconstitution of the Human Nigro-striatal Pathway on-a-Chip Reveals OPA1-Dependent Mitochondrial Defects and Loss of Dopaminergic Synapses.
Iannielli A, Ugolini GS, Cordiglieri C, Bido S, Rubio A, Colasante G, Valtorta M, Cabassi T, Rasponi M, Broccoli V
Cell reports (2019) 2913: 4646-4656.e4. 160 003 ICC; tested species: human

Rac1 and Rac3 GTPases differently influence the morphological maturation of dendritic spines in hippocampal neurons.
Pennucci R, Gucciardi I, de Curtis I
PloS one (2019) 148: e0220496. 160 003 ICC; tested species: mouse

Differential Properties of the Synaptogenic Activities of the Neurexin Ligands Neuroligin1 and LRRTM2.
Dagar S, Gottmann K
Frontiers in molecular neuroscience (2019) 12: 269. 160 003 ICC; tested species: mouse

Setd5 haploinsufficiency alters neuronal network connectivity and leads to autistic-like behaviors in mice.
Moore SM, Seidman JS, Ellegood J, Gao R, Savchenko A, Troutman TD, Abe Y, Stender J, Lee D, Wang S, Voytek B, et al.
Translational psychiatry (2019) 91: 24. 160 003 ICC; tested species: mouse

Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk.
Huang YA, Zhou B, Nabet AM, Wernig M, Südhof TC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) 3937: 7408-7427. 160 003 ICC; tested species: human

A toolbox of nanobodies developed and validated for use as intrabodies and nanoscale immunolabels in mammalian brain neurons.
Dong JX, Lee Y, Kirmiz M, Palacio S, Dumitras C, Moreno CM, Sando R, Santana LF, Südhof TC, Gong B, Murray KD, et al.
eLife (2019) 8: . 160 003 ICC; tested species: mouse

Glutaredoxin1 diminishes Aβ mediated oxidation of F-actin and reverses cognitive deficits in an Alzheimer's disease mouse model.
Kommaddi RP, Tomar DS, Karunakaran S, Bapat D, Nanguneri S, Ray A, Schneider BL, Nair D, Ravindranath V
Antioxidants & redox signaling (2019) : . 160 003 ICC; tested species: mouse

Intracellular Zn2+ transients modulate global gene expression in dissociated rat hippocampal neurons.
Sanford L, Carpenter MC, Palmer AE
Scientific reports (2019) 91: 9411. 160 003 ICC; tested species: rat

Bassoon Controls Presynaptic Autophagy through Atg5.
Okerlund ND, Schneider K, Leal-Ortiz S, Montenegro-Venegas C, Kim SA, Garner LC, Waites CL, Gundelfinger ED, Reimer RJ, Garner CC
Neuron (2018) 973: 727. 160 003 ICC; tested species: mouse

Mapping molecular assemblies with fluorescence microscopy and object-based spatial statistics.
Lagache T, Grassart A, Dallongeville S, Faklaris O, Sauvonnet N, Dufour A, Danglot L, Olivo-Marin JC
Nature communications (2018) 91: 698. 160 003 ICC; tested species: mouse

Aβ mediates F-actin disassembly in dendritic spines leading to cognitive deficits in Alzheimer's disease.
Kommaddi RP, Das D, Karunakaran S, Nanguneri S, Bapat D, Ray A, Shaw E, Bennett DA, Nair D, Ravindranath V
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 385: 1085-1099. 160 003 ICC; tested species: mouse

PICK1 regulates AMPA receptor endocytosis via direct interactions with AP2 α-appendage and dynamin.
Fiuza M, Rostosky CM, Parkinson GT, Bygrave AM, Halemani N, Baptista M, Milosevic I, Hanley JG
The Journal of cell biology (2017) 21610: 3323-3338. 160 003 ICC; tested species: rat

Bassoon Controls Presynaptic Autophagy through Atg5.
Okerlund ND, Schneider K, Leal-Ortiz S, Montenegro-Venegas C, Kim SA, Garner LC, Waites CL, Gundelfinger ED, Reimer RJ, Garner CC
Neuron (2017) 934: 897-913.e7. 160 003 ICC; tested species: mouse

The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn.
Abraira VE, Kuehn ED, Chirila AM, Springel MW, Toliver AA, Zimmerman AL, Orefice LL, Boyle KA, Bai L, Song BJ, Bashista KA, et al.
Cell (2017) 1681-2: 295-310.e19. 160 003 ICC; tested species: mouse

RNA localization is a key determinant of neurite-enriched proteome.
Zappulo A, van den Bruck D, Ciolli Mattioli C, Franke V, Imami K, McShane E, Moreno-Estelles M, Calviello L, Filipchyk A, Peguero-Sanchez E, Müller T, et al.
Nature communications (2017) 81: 583. 160 003 ICC; tested species: mouse

Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy.
Altmüller F, Pothula S, Annamneedi A, Nakhaei-Rad S, Montenegro-Venegas C, Pina-Fernández E, Marini C, Santos M, Schanze D, Montag D, Ahmadian MR, et al.
PLoS genetics (2017) 133: e1006684. 160 003 ICC

Activity-Dependent Degradation of Synaptic Vesicle Proteins Requires Rab35 and the ESCRT Pathway.
Sheehan P, Zhu M, Beskow A, Vollmer C, Waites CL
The Journal of neuroscience : the official journal of the Society for Neuroscience (2016) 3633: 8668-86. 160 003 ICC; tested species: rat

Neuronal activity controls transsynaptic geometry.
Glebov OO, Cox S, Humphreys L, Burrone J
Scientific reports (2016) 6: 22703. 160 003 ICC

Multicolour Multilevel STED nanoscopy of Actin/Spectrin Organization at Synapses.
Sidenstein SC, D'Este E, Böhm MJ, Danzl JG, Belov VN, Hell SW
Scientific reports (2016) 6: 26725. 160 003 ICC

STIM2 regulates PKA-dependent phosphorylation and trafficking of AMPARs.
Garcia-Alvarez G, Lu B, Yap KA, Wong LC, Thevathasan JV, Lim L, Ji F, Tan KW, Mancuso JJ, Tang W, Poon SY, et al.
Molecular biology of the cell (2015) 266: 1141-59. 160 003 ICC

Topographic Mapping of the Synaptic Cleft into Adhesive Nanodomains.
Perez de Arce K, Schrod N, Metzbower SWR, Allgeyer E, Kong GK, Tang AH, Krupp AJ, Stein V, Liu X, Bewersdorf J, Blanpied TA, et al.
Neuron (2015) 886: 1165-1172. 160 003 ICC; tested species: rat

Synaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo.
Ivanova D, Dirks A, Montenegro-Venegas C, Schöne C, Altrock WD, Marini C, Frischknecht R, Schanze D, Zenker M, Gundelfinger ED, Fejtova A, et al.
The EMBO journal (2015) 348: 1056-77. 160 003 ICC

High abundance of BDNF within glutamatergic presynapses of cultured hippocampal neurons.
Andreska T, Aufmkolk S, Sauer M, Blum R
Frontiers in cellular neuroscience (2014) 8: 107. 160 003 ICC; tested species: mouse

Effects of erythropoietin in murine-induced pluripotent cell-derived panneural progenitor cells.
Offen N, Flemming J, Kamawal H, Ahmad R, Wolber W, Geis C, Zaehres H, Schöler HR, Ehrenreich H, Müller AM, Sirén AL, et al.
Molecular medicine (Cambridge, Mass.) (2013) 19: 399-408. 160 003 ICC; tested species: mouse

Glucocorticoid-related molecular signaling pathways regulating hippocampal neurogenesis.
Anacker C, Cattaneo A, Luoni A, Musaelyan K, Zunszain PA, Milanesi E, Rybka J, Berry A, Cirulli F, Thuret S, Price J, et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (2013) 385: 872-83. 160 003 ICC; tested species: human

mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking.
Wentzel C, Sommer JE, Nair R, Stiefvater A, Sibarita JB, Scheiffele P
Neuron (2013) 786: 1012-23. 160 003 ICC; tested species: mouse

Activity-dependent regulation of the sumoylation machinery in rat hippocampal neurons.
Loriol C, Khayachi A, Poupon G, Gwizdek C, Martin S
Biology of the cell (2013) 1051: 30-45. 160 003 ICC; tested species: rat

Developmental regulation and spatiotemporal redistribution of the sumoylation machinery in the rat central nervous system.
Loriol C, Parisot J, Poupon G, Gwizdek C, Martin S
PloS one (2012) 73: e33757. 160 003 ICC; tested species: rat

Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation.
Grabrucker AM, Knight MJ, Proepper C, Bockmann J, Joubert M, Rowan M, Nienhaus GU, Garner CC, Bowie JU, Kreutz MR, Gundelfinger ED, et al.
The EMBO journal (2011) 303: 569-81. 160 003 ICC; tested species: rat

Piccolo regulates the dynamic assembly of presynaptic F-actin.
Waites CL, Leal-Ortiz SA, Andlauer TF, Sigrist SJ, Garner CC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3140: 14250-63. 160 003 ICC; tested species: mouse

[Artificial urinary sphincter in the treatment of neurogenic bladder in children].
Guys JM, Faure F, Chiapello A, Monfort G
Chirurgie pediatrique (1988) 294: 178-80. 160 003 ICC, IHC; tested species: rat

Endolymphatic hydrops and cochlear synaptopathy after noise exposure are distinct sequelae of hair cell stereociliary bundle trauma.
Fong ML, Paik CB, Quiñones PM, Walker CB, Serafino MJ, Pan DW, Martinez E, Wang J, Phillips GW, Applegate BE, Gratton MA, et al.
Scientific reports (2024) 141: 25660. 160 003 IHC; tested species: mouse

Multimodal sensory control of motor performance by glycinergic interneurons of the mouse spinal cord deep dorsal horn.
Gradwell MA, Ozeri-Engelhard N, Eisdorfer JT, Laflamme OD, Gonzalez M, Upadhyay A, Medlock L, Shrier T, Patel KR, Aoki A, Gandhi M, et al.
Neuron (2024) 1128: 1302-1327.e13. 160 003 IHC; tested species: mouse

Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model.
Martin Flores N, Podpolny M, McLeod F, Workman I, Crawford K, Ivanov D, Leonenko G, Escott-Price V, Salinas PC
eLife (2024) 12: . 160 003 IHC; tested species: mouse

BIN1K358R suppresses glial response to plaques in mouse model of Alzheimer's disease.
Garcia-Agudo LF, Shi Z, Smith IF, Kramár EA, Tran K, Kawauchi S, Wang S, Collins S, Walker A, Shi KX, Neumann J, et al.
Alzheimer's & dementia : the journal of the Alzheimer's Association (2024) : . 160 003 IHC; tested species: mouse

Synaptic injury in the inner plexiform layer of the retina is associated with progression in multiple sclerosis.
Cordano C, Werneburg S, Abdelhak A, Bennett DJ, Beaudry-Richard A, Duncan GJ, Oertel FC, Boscardin WJ, Yiu HH, Jabassini N, Merritt L, et al.
Cell reports. Medicine (2024) : 101490. 160 003 IHC; tested species: mouse

Demyelination and Na+ Channel Redistribution Underlie Auditory and Vestibular Dysfunction in PMP22-Null Mice.
Lee JH, Park S, Perez-Flores MC, Chen Y, Kang M, Choi J, Levine L, Gratton MA, Zhao J, Notterpek L, Yamoah EN, et al.
eNeuro (2024) 112: . 160 003 IHC; tested species: mouse

H-Ras induces exuberant de novo dendritic protrusion growth in mature neurons regardless of cell type.
Krüssel S, Deb I, Son S, Ewall G, Chang M, Lee HK, Heo WD, Kwon HB
iScience (2024) 278: 110535. 160 003 IHC; tested species: mouse

Growth hormone promotes myelin repair after chronic hypoxia via triggering pericyte-dependent angiogenesis.
Ren SY, Xia Y, Yu B, Lei QJ, Hou PF, Guo S, Wu SL, Liu W, Yang SF, Jiang YB, Chen JF, et al.
Neuron (2024) : . 160 003 IHC; tested species: mouse

P2X7 purinergic receptor modulates dentate gyrus excitatory neurotransmission and alleviates schizophrenia-like symptoms in mouse.
Huang L, Mut-Arbona P, Varga B, Török B, Brunner J, Arszovszki A, Iring A, Kisfali M, Vizi ES, Sperlágh B
iScience (2023) 269: 107560. 160 003 IHC; tested species: mouse

Preclinical long-term safety of intraspinal transplantation of human dorsal spinal GABA neural progenitor cells.
Zheng X, Liu Z, He Z, Xu J, Wang Y, Gong C, Zhang R, Zhang SC, Chen H, Wang W
iScience (2023) 2611: 108306. 160 003 IHC; tested species: rat

Time-dependent and selective microglia-mediated removal of spinal synapses in neuropathic pain.
Yousefpour N, Locke S, Deamond H, Wang C, Marques L, St-Louis M, Ouellette J, Khoutorsky A, De Koninck Y, Ribeiro-da-Silva A
Cell reports (2023) 421: 112010. 160 003 IHC; tested species: mouse

Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions.
de Arce KP, Ribic A, Chowdhury D, Watters K, Thompson GJ, Sanganahalli BG, Lippard ETC, Rohlmann A, Strittmatter SM, Missler M, Hyder F, et al.
Nature communications (2023) 141: 459. 160 003 IHC; tested species: mouse

γ-Protocadherins control synapse formation and peripheral branching of touch sensory neurons.
Meltzer S, Boulanger KC, Chirila AM, Osei-Asante E, DeLisle M, Zhang Q, Kalish BT, Tasnim A, Huey EL, Fuller LC, Flaherty EK, et al.
Neuron (2023) 11111: 1776-1794.e10. 160 003 IHC; tested species: mouse

Noncanonical Activity of Tissue Inhibitor of Metalloproteinases 2 (TIMP2) Improves Cognition and Synapse Density in Aging.
Britton R, Wasley T, Harish R, Holz C, Hall J, Yee DC, Melton Witt J, Booth EA, Braithwaite S, Czirr E, Kerrisk Campbell M, et al.
eNeuro (2023) 106: . 160 003 IHC; tested species: mouse

Stress induces behavioral abnormalities by increasing expression of phagocytic receptor, MERTK, in astrocytes to promote synapse phagocytosis.
Byun YG, Kim NS, Kim G, Jeon YS, Choi JB, Park CW, Kim K, Jang H, Kim J, Kim E, Han YM, et al.
Immunity (2023) : . 160 003 IHC; tested species: mouse

P2Y6 receptor-dependent microglial phagocytosis of synapses mediates synaptic and memory loss in aging.
Dundee JM, Puigdellívol M, Butler R, Cockram TOJ, Brown GC
Aging cell (2023) 222: e13761. 160 003 IHC; tested species: mouse

Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease.
Wilton DK, Mastro K, Heller MD, Gergits FW, Willing CR, Fahey JB, Frouin A, Daggett A, Gu X, Kim YA, Faull RLM, et al.
Nature medicine (2023) : . 160 003 IHC; tested species: mouse

Microglia are dispensable for developmental dendrite pruning of mitral cells in mice.
Niiyama T, Fujimoto S, Imai T
eNeuro (2023) : . 160 003 IHC; tested species: mouse

Lipofuscin-like autofluorescence within microglia and its impact on studying microglial engulfment.
Stillman JM, Mendes Lopes F, Lin JP, Hu K, Reich DS, Schafer DP
Nature communications (2023) 141: 7060. 160 003 IHC; tested species: mouse

Machine learning identifies experimental brain metastasis subtypes based on their influence on neural circuits.
Sanchez-Aguilera A, Masmudi-Martín M, Navas-Olive A, Baena P, Hernández-Oliver C, Priego N, Cordón-Barris L, Alvaro-Espinosa L, García S, Martínez S, Lafarga M, et al.
Cancer cell (2023) 419: 1637-1649.e11. 160 003 IHC; tested species: mouse

The synaptic basis of activity-dependent eye-specific competition.
Zhang C, Yadav S, Speer CM
Cell reports (2023) 422: 112085. 160 003 IHC; tested species: mouse

A direct spino-cortical circuit bypassing the thalamus modulates nociception.
Cai B, Wu D, Xie H, Chen Y, Wang H, Jin S, Song Y, Li A, Huang S, Wang S, Lu Y, et al.
Cell research (2023) 3310: 775-789. 160 003 IHC; tested species: mouse

Skin-type-dependent development of murine mechanosensory neurons.
Koutsioumpa C, Santiago C, Jacobs K, Lehnert BP, Barrera V, Hutchinson JN, Schmelyun D, Lehoczky JA, Paul DL, Ginty DD
Developmental cell (2023) : . 160 003 IHC; tested species: mouse

Mild Traumatic Brain Injury-Induced Disruption of the Blood-Brain Barrier Triggers an Atypical Neuronal Response.
Munoz-Ballester C, Mahmutovic D, Rafiqzad Y, Korot A, Robel S
Frontiers in cellular neuroscience (2022) 16: 821885. 160 003 IHC; tested species: mouse

Versatile, do-it-yourself, low-cost spinning disk confocal microscope.
Halpern AR, Lee MY, Howard MD, Woodworth MA, Nicovich PR, Vaughan JC
Biomedical optics express (2022) 132: 1102-1120. 160 003 IHC; tested species: mouse

Hippocampal Excitatory Synaptic Transmission and Plasticity Are Differentially Altered during Postnatal Development by Loss of the X-Linked Intellectual Disability Protein Oligophrenin-1.
Cresto N, Lebrun N, Dumont F, Letourneur F, Billuart P, Rouach N
Cells (2022) 119: . 160 003 IHC; tested species: mouse

Teneurins assemble into presynaptic nanoclusters that promote synapse formation via postsynaptic non-teneurin ligands.
Zhang X, Lin PY, Liakath-Ali K, Südhof TC
Nature communications (2022) 131: 2297. 160 003 IHC; tested species: mouse

Microglial control of neuronal development via somatic purinergic junctions.
Cserép C, Schwarcz AD, Pósfai B, László ZI, Kellermayer A, Környei Z, Kisfali M, Nyerges M, Lele Z, Katona I, Ádám Dénes , et al.
Cell reports (2022) 4012: 111369. 160 003 IHC; tested species: mouse

Microglia maintain the normal structure and function of the hippocampal astrocyte network.
Du Y, Brennan FH, Popovich PG, Zhou M
Glia (2022) 707: 1359-1379. 160 003 IHC; tested species: mouse

MANF supports the inner hair cell synapse and the outer hair cell stereocilia bundle in the cochlea.
Ikäheimo K, Herranen A, Iivanainen V, Lankinen T, Aarnisalo AA, Sivonen V, Patel KA, Demir K, Saarma M, Lindahl M, Pirvola U, et al.
Life science alliance (2022) 52: . 160 003 IHC; tested species: mouse

Endolymphatic Hydrops is a Marker of Synaptopathy Following Traumatic Noise Exposure.
Badash I, Quiñones PM, Oghalai KJ, Wang J, Lui CG, Macias-Escriva F, Applegate BE, Oghalai JS
Frontiers in cell and developmental biology (2021) 9: 747870. 160 003 IHC; tested species: mouse

Human ALS/FTD brain organoid slice cultures display distinct early astrocyte and targetable neuronal pathology.
Szebényi K, Wenger LMD, Sun Y, Dunn AWE, Limegrover CA, Gibbons GM, Conci E, Paulsen O, Mierau SB, Balmus G, Lakatos A, et al.
Nature neuroscience (2021) 2411: 1542-1554. 160 003 IHC; tested species: human

Acute post-injury blockade of α2δ-1 calcium channel subunits prevents pathological autonomic plasticity after spinal cord injury.
Brennan FH, Noble BT, Wang Y, Guan Z, Davis H, Mo X, Harris C, Eroglu C, Ferguson AR, Popovich PG
Cell reports (2021) 344: 108667. 160 003 IHC; tested species: mouse

Characterizing the Retinal Phenotype of the Thy1-h[A30P]α-syn Mouse Model of Parkinson's Disease.
Veys L, Devroye J, Lefevere E, Cools L, Vandenabeele M, De Groef L
Frontiers in neuroscience (2021) 15: 726476. 160 003 IHC; tested species: mouse

Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration.
Ding X, Wang J, Huang M, Chen Z, Liu J, Zhang Q, Zhang C, Xiang Y, Zen K, Li L
Nature communications (2021) 121: 2030. 160 003 IHC; tested species: mouse

Three-dimensional adaptive optical nanoscopy for thick specimen imaging at sub-50-nm resolution.
Hao X, Allgeyer ES, Lee DR, Antonello J, Watters K, Gerdes JA, Schroeder LK, Bottanelli F, Zhao J, Kidd P, Lessard MD, et al.
Nature methods (2021) 186: 688-693. 160 003 IHC; tested species: mouse

Local Translation in Perisynaptic Astrocytic Processes Is Specific and Changes after Fear Conditioning.
Mazaré N, Oudart M, Moulard J, Cheung G, Tortuyaux R, Mailly P, Mazaud D, Bemelmans AP, Boulay AC, Blugeon C, Jourdren L, et al.
Cell reports (2020) 328: 108076. 160 003 IHC; tested species: mouse

Microglia monitor and protect neuronal function through specialized somatic purinergic junctions.
Cserép C, Pósfai B, Lénárt N, Fekete R, László ZI, Lele Z, Orsolits B, Molnár G, Heindl S, Schwarcz AD, Ujvári K, et al.
Science (New York, N.Y.) (2020) 3676477: 528-537. 160 003 IHC; tested species: mouse

Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model.
van Olst L, Verhaege D, Franssen M, Kamermans A, Roucourt B, Carmans S, Ytebrouck E, van der Pol SMA, Wever D, Popovic M, Vandenbroucke RE, et al.
Neurobiology of aging (2020) 89: 89-98. 160 003 IHC; tested species: mouse

REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis.
Griffin P, Sheehan PW, Dimitry JM, Guo C, Kanan MF, Lee J, Zhang J, Musiek ES
eLife (2020) 9: . 160 003 IHC; tested species: mouse

LTP Induction Boosts Glutamate Spillover by Driving Withdrawal of Perisynaptic Astroglia.
Henneberger C, Bard L, Panatier A, Reynolds JP, Kopach O, Medvedev NI, Minge D, Herde MK, Anders S, Kraev I, Heller JP, et al.
Neuron (2020) : . 160 003 IHC; tested species: mouse

Activation of Neurogenesis in Multipotent Stem Cells Cultured In Vitro and in the Spinal Cord Tissue After Severe Injury by Inhibition of Glycogen Synthase Kinase-3.
Rodriguez-Jimenez FJ, Vilches A, Perez-Arago MA, Clemente E, Roman R, Leal J, Castro AA, Fustero S, Moreno-Manzano V, Jendelova P, Stojkovic M, et al.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics (2020) : . 160 003 IHC; tested species: mouse

Protocol for BATTLE-1EX: A High-Resolution Imaging Method to Visualize Whole Synaptic Structures and their Components in the Nervous System.
Inoue A, Kobayashi T, Hirai H, Kanaya N, Kohara K
STAR protocols (2020) 13: 100166. 160 003 IHC; tested species: mouse

Scalable and Isotropic Expansion of Tissues with Simply Tunable Expansion Ratio.
Park HE, Choi D, Park JS, Sim C, Park S, Kang S, Yim H, Lee M, Kim J, Pac J, Rhee K, et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2019) 622: 1901673. 160 003 IHC; tested species: mouse

Combining super-resolution microscopy with neuronal network recording using magnesium fluoride thin films as cover layer for multi-electrode array technology.
Schmidl L, Schmidl G, Gawlik A, Dellith J, Hübner U, Tympel V, Schmidl F, Plentz J, Geis C, Haselmann H
Scientific reports (2019) 91: 16110. 160 003 IHC; tested species: mouse

Structural and functional connections between the median and the ventrolateral preoptic nucleus.
Walter A, van der Spek L, Hardy E, Bemelmans AP, Rouach N, Rancillac A
Brain structure & function (2019) 2249: 3045-3057. 160 003 IHC, iDISCO; tested species: mouse

Region-specific and activity-dependent regulation of SVZ neurogenesis and recovery after stroke.
Liang H, Zhao H, Gleichman A, Machnicki M, Telang S, Tang S, Rshtouni M, Ruddell J, Carmichael ST
Proceedings of the National Academy of Sciences of the United States of America (2019) : . 160 003 IHC; tested species: mouse

Imaging tripartite synapses using super-resolution microscopy.
Heller JP, Odii T, Zheng K, Rusakov DA
Methods (San Diego, Calif.) (2019) : . 160 003 IHC; tested species: mouse

Vaccinia-related kinase 2 plays a critical role in microglia-mediated synapse elimination during neurodevelopment.
Lee J, Lee S, Ryu YJ, Lee D, Kim S, Seo JY, Oh E, Paek SH, Kim SU, Ha CM, Choi SY, et al.
Glia (2019) : . 160 003 IHC; tested species: mouse

Young bone marrow transplantation preserves learning and memory in old mice.
Das MM, Godoy M, Chen S, Moser VA, Avalos P, Roxas KM, Dang I, Yáñez A, Zhang W, Bresee C, Arditi M, et al.
Communications biology (2019) 2: 73. 160 003 IHC; tested species: mouse

Functional Synaptic Architecture of Callosal Inputs in Mouse Primary Visual Cortex.
Lee KS, Vandemark K, Mezey D, Shultz N, Fitzpatrick D
Neuron (2019) 1013: 421-428.e5. 160 003 IHC; tested species: mouse

Light-sheet microscopy of cleared tissues with isotropic, subcellular resolution.
Chakraborty T, Driscoll MK, Jeffery E, Murphy MM, Roudot P, Chang BJ, Vora S, Wong WM, Nielson CD, Zhang H, Zhemkov V, et al.
Nature methods (2019) 1611: 1109-1113. 160 003 IHC; tested species: mouse

Restorative effects of human neural stem cell grafts on the primate spinal cord.
Rosenzweig ES, Brock JH, Lu P, Kumamaru H, Salegio EA, Kadoya K, Weber JL, Liang JJ, Moseanko R, Hawbecker S, Huie JR, et al.
Nature medicine (2018) : . 160 003 IHC; tested species: human

Enhancing Oligodendrocyte Myelination Rescues Synaptic Loss and Improves Functional Recovery after Chronic Hypoxia.
Wang F, Yang YJ, Yang N, Chen XJ, Huang NX, Zhang J, Wu Y, Liu Z, Gao X, Li T, Pan GQ, et al.
Neuron (2018) 994: 689-701.e5. 160 003 IHC; tested species: mouse

CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development.
Lehrman EK, Wilton DK, Litvina EY, Welsh CA, Chang ST, Frouin A, Walker AJ, Heller MD, Umemori H, Chen C, Stevens B, et al.
Neuron (2018) 1001: 120-134.e6. 160 003 IHC; tested species: mouse

The presynaptic ribbon maintains vesicle populations at the hair cell afferent fiber synapse.
Becker L, Schnee ME, Niwa M, Sun W, Maxeiner S, Talaei S, Kachar B, Rutherford MA, Ricci AJ
eLife (2018) 7: . 160 003 IHC

Iterative expansion microscopy.
Chang JB, Chen F, Yoon YG, Jung EE, Babcock H, Kang JS, Asano S, Suk HJ, Pak N, Tillberg PW, Wassie AT, et al.
Nature methods (2017) 146: 593-599. 160 003 IHC; tested species: mouse

Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.
Espuny-Camacho I, Arranz AM, Fiers M, Snellinx A, Ando K, Munck S, Bonnefont J, Lambot L, Corthout N, Omodho L, Vanden Eynden E, et al.
Neuron (2017) 935: 1066-1081.e8. 160 003 IHC; tested species: human,mouse

Deletion of the Fractalkine Receptor, CX3CR1, Improves Endogenous Repair, Axon Sprouting, and Synaptogenesis after Spinal Cord Injury in Mice.
Freria CM, Hall JC, Wei P, Guan Z, McTigue DM, Popovich PG
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 3713: 3568-3587. 160 003 IHC; tested species: mouse

Transcriptomic Analysis of Ribosome-Bound mRNA in Cortical Neurites In Vivo.
Ouwenga R, Lake AM, O'Brien D, Mogha A, Dani A, Dougherty JD
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 3736: 8688-8705. 160 003 IHC; tested species: mouse

Multiplexed and scalable super-resolution imaging of three-dimensional protein localization in size-adjustable tissues.
Ku T, Swaney J, Park JY, Albanese A, Murray E, Cho JH, Park YG, Mangena V, Chen J, Chung K
Nature biotechnology (2016) 349: 973-81. 160 003 IHC; tested species: mouse

Hippocampal Homer1 levels influence motivational behavior in an operant conditioning task.
Wagner KV, Häusl AS, Pöhlmann ML, Hartmann J, Labermaier C, Müller MB, Schmidt MV
PloS one (2014) 91: e85975. 160 003 IHC; tested species: mouse

FMRP regulates multipolar to bipolar transition affecting neuronal migration and cortical circuitry.
La Fata G, Gärtner A, Domínguez-Iturza N, Dresselaers T, Dawitz J, Poorthuis RB, Averna M, Himmelreich U, Meredith RM, Achsel T, Dotti CG, et al.
Nature neuroscience (2014) 1712: 1693-700. 160 003 IHC; tested species: mouse

Homer1 mediates acute stress-induced cognitive deficits in the dorsal hippocampus.
Wagner KV, Hartmann J, Mangold K, Wang XD, Labermaier C, Liebl C, Wolf M, Gassen NC, Holsboer F, Rein T, Müller MB, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 339: 3857-64. 160 003 IHC; tested species: mouse

Superresolution imaging of chemical synapses in the brain.
Dani A, Huang B, Bergan J, Dulac C, Zhuang X
Neuron (2010) 685: 843-56. 160 003 IHC; tested species: mouse

Delayed appearance of the scaffolding proteins PSD-95 and Homer-1 at the developing rat calyx of Held synapse.
Soria Van Hoeve JS, Borst JG
The Journal of comparative neurology (2010) 51822: 4581-90. 160 003 IHC; tested species: rat

Synaptic Organization of VGLUT3 Expressing Low-Threshold Mechanosensitive C Fiber Terminals in the Rodent Spinal Cord.
Larsson M, Broman J
eNeuro () 61: . 160 003 IHC; tested species: rat

Mitochondrial Ultrastructure Is Coupled to Synaptic Performance at Axonal Release Sites.
Cserép C, Pósfai B, Schwarcz AD, Dénes Á
eNeuro () 51: . 160 003 IHC; tested species: mouse

Enhanced synaptic protein visualization by multicolor super-resolution expansion microscopy.
Eilts J, Reinhard S, Michetschläger N, Werner C, Sauer M
Neurophotonics (2023) 104: 044412. 160 003 ExM; tested species: mouse

Heat denaturation enables multicolor X10-STED microscopy.
Saal KA, Shaib AH, Mougios N, Crzan D, Opazo F, Rizzoli SO
Scientific reports (2023) 131: 5366. 160 003 ExM; tested species: rat

GelMap: intrinsic calibration and deformation mapping for expansion microscopy.
Damstra HGJ, Passmore JB, Serweta AK, Koutlas I, Burute M, Meye FJ, Akhmanova A, Kapitein LC
Nature methods (2023) 2010: 1573-1580. 160 003 ExM; tested species: mouse

Spatial proteomics in neurons at single-protein resolution.
Unterauer EM, Shetab Boushehri S, Jevdokimenko K, Masullo LA, Ganji M, Sograte-Idrissi S, Kowalewski R, Strauss S, Reinhardt SCM, Perovic A, Marr C, et al.
Cell (2024) 1877: 1785-1800.e16. 160 003 DNA-PAINT; tested species: rat

Distinct SAP102 and PSD-95 nano-organization defines multiple types of synaptic scaffold protein domains at single synapses.
Metzbower SR, Dharmasri PA, Levy AD, Anderson MC, Blanpied TA
bioRxiv : the preprint server for biology (2023) : . 160 003 DNA-PAINT; tested species: rat

Fast DNA-PAINT imaging using a deep neural network.
Narayanasamy KK, Rahm JV, Tourani S, Heilemann M
Nature communications (2022) 131: 5047. 160 003 DNA-PAINT; tested species: rat

Cat. No.: 160 003

Amount: 50 µg

Price: $475.00

Proteome dynamics during homeostatic scaling in cultured neurons.
Dörrbaum AR, Alvarez-Castelao B, Nassim-Assir B, Langer JD, Schuman EM
eLife (2020) 9: . 160 003 WB; tested species: rat

How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs.
Acuna C, Liu X, Südhof TC
Neuron (2016) 914: 792-807. 160 003 WB

Integrated staging of morphofunctional connectivity in neuronal cultures.
Verstraelen P, Verschuuren M, De Vos WH
STAR protocols (2024) 52: 102957. 160 003 ICC

Long-Term Cultures of Spinal Cord Interneurons.
Vargova I, Kriska J, Kwok JCF, Fawcett JW, Jendelova P
Frontiers in cellular neuroscience (2022) 16: 827628. 160 003 ICC; tested species: mouse

Latrophilin GPCR signaling mediates synapse formation.
Sando R, Südhof TC
eLife (2021) 10: . 160 003 ICC; tested species: mouse

A practical guide to optimization in X10 expansion microscopy.
Truckenbrodt S, Sommer C, Rizzoli SO, Danzl JG
Nature protocols (2019) : . 160 003 ICC; tested species: rat

Bassoon Controls Presynaptic Autophagy through Atg5.
Okerlund ND, Schneider K, Leal-Ortiz S, Montenegro-Venegas C, Kim SA, Garner LC, Waites CL, Gundelfinger ED, Reimer RJ, Garner CC
Neuron (2017) 934: 897-913.e7. 160 003 ICC; tested species: mouse

Neuronal activity controls transsynaptic geometry.
Glebov OO, Cox S, Humphreys L, Burrone J
Scientific reports (2016) 6: 22703. 160 003 ICC

Multicolour Multilevel STED nanoscopy of Actin/Spectrin Organization at Synapses.
Sidenstein SC, D'Este E, Böhm MJ, Danzl JG, Belov VN, Hell SW
Scientific reports (2016) 6: 26725. 160 003 ICC

Microglia are dispensable for developmental dendrite pruning of mitral cells in mice.
Niiyama T, Fujimoto S, Imai T
eNeuro (2023) : . 160 003 IHC; tested species: mouse

The synaptic basis of activity-dependent eye-specific competition.
Zhang C, Yadav S, Speer CM
Cell reports (2023) 422: 112085. 160 003 IHC; tested species: mouse

Microglia maintain the normal structure and function of the hippocampal astrocyte network.
Du Y, Brennan FH, Popovich PG, Zhou M
Glia (2022) 707: 1359-1379. 160 003 IHC; tested species: mouse

Imaging tripartite synapses using super-resolution microscopy.
Heller JP, Odii T, Zheng K, Rusakov DA
Methods (San Diego, Calif.) (2019) : . 160 003 IHC; tested species: mouse

Superresolution imaging of chemical synapses in the brain.
Dani A, Huang B, Bergan J, Dulac C, Zhuang X
Neuron (2010) 685: 843-56. 160 003 IHC; tested species: mouse

Synaptic Organization of VGLUT3 Expressing Low-Threshold Mechanosensitive C Fiber Terminals in the Rodent Spinal Cord.
Larsson M, Broman J
eNeuro () 61: . 160 003 IHC; tested species: rat

Mitochondrial Ultrastructure Is Coupled to Synaptic Performance at Axonal Release Sites.
Cserép C, Pósfai B, Schwarcz AD, Dénes Á
eNeuro () 51: . 160 003 IHC; tested species: mouse

Heat denaturation enables multicolor X10-STED microscopy.
Saal KA, Shaib AH, Mougios N, Crzan D, Opazo F, Rizzoli SO
Scientific reports (2023) 131: 5366. 160 003 ExM; tested species: rat

Fast DNA-PAINT imaging using a deep neural network.
Narayanasamy KK, Rahm JV, Tourani S, Heilemann M
Nature communications (2022) 131: 5047. 160 003 DNA-PAINT; tested species: rat

ICC

IHC

IHC-P

Background

Homer is a scaffolding protein of the post synaptic density (PSD) and enriched at excitatory synapses. The protein binds metabotropic glutamate receptors, TRPC1, proteins of the Shank family and others. By aggregating these proteins into clusters, homer was suggested to organize distinct signalling domains.
Three isoforms, Homer 1, 2 and 3 have been described. Each of these isoforms is subject to alternative splicing yielding the splice variants a, b, c, d.

1 ) Kammermeier PJ et al., BMC Neurosci (2006)
2 ) Yamamoto K et al., Eur. J. Neurosci. (2005)
3 ) Thomas U et al., J. Neurochem. (2002)
4 ) Ango F et al., Mol. Cell. Neurosci. (2002)
5 ) Sala C et al., Neuron (2001)
6 ) Ciruela F et al., Mol. Cell. Neurosci. (2000)
7 ) Xiao B et al., Curr. Opin. Neurobiol. (2000)
8 ) Tu JC et al., Neuron (1999)
9 ) Brakeman PR et al., Nature (1997)
10 ) Shiraishi Y et al., J. Comp. Neurol. (2004)

Protocols

Standard protocol

ICC

Pre-adsorption protocol

IHC

IHC-P

ELISA

Membrane proteins

OTHER

Preabsorbtion

Other products for this target

Homer1 antibody - 160 003

References for Homer1 - 160 003