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IBA 1 - 234 003

A calcium binding protein specific for microglia
Polyclonal rabbit purified antibody
Cat. No.: 234 003
Amount: 50 µg
Price: 370.00 €
Cat. No. 234 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 1000 gallery  
IHC: 1 : 1000 up to 1 : 5000     gallery  
IHC-P/FFPE: 1 : 200 up to 1 : 2000     gallery  
Immunogen Synthetic peptide corresponding to AA 134 to 147 from rat IBA1 (UniProt Id: P55009)
Reactivity Reacts with: human (P55008), rat (P55009), mouse (O70200).
Other species not tested yet.
Specificity Specific for IBA 1.
Matching control protein/peptide 234-0P
Data sheet 234_003.pdf

References for IBA 1 - 234 003

Destructive Effect of Intravitreal Heat Shock Protein 27 Application on Retinal Ganglion Cells and Neurofilament.
Grotegut P, Kuehn S, Dick HB, Joachim SC
International journal of molecular sciences (2020) 212: . 234 003 WB; tested species: rat
Intravitreal S100B Injection Triggers a Time-Dependent Microglia Response in a Pro-Inflammatory Manner in Retina and Optic Nerve.
Grotegut P, Kuehn S, Meißner W, Dick HB, Joachim SC
Molecular neurobiology (2019) : . 234 003 WB; tested species: rat
High fat diet treatment impairs hippocampal long-term potentiation without alterations of the core neuropathological features of Alzheimer disease.
Salas IH, Weerasekera A, Ahmed T, Callaerts-Vegh Z, Himmelreich U, D'Hooge R, Balschun D, Saido TC, De Strooper B, Dotti CG
Neurobiology of disease (2018) 113: 82-96. 234 003 WB; tested species: mouse
Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition.
Richter MC, Ludewig S, Winschel A, Abel T, Bold C, Salzburger LR, Klein S, Han K, Weyer SW, Fritz AK, Laube B, et al.
The EMBO journal (2018) : . 234 003 WB, IHC; tested species: mouse
Interaction of complement system and microglia activation in retina and optic nerve in a NMDA damage model.
Kuehn S, Reinehr S, Stute G, Rodust C, Grotegut P, Hensel AT, Burkhard Dick H, Joachim SC
Molecular and cellular neurosciences (2018) : . 234 003 WB; tested species: mouse
Nanostructured Lipid Carriers Made of Ω-3 Polyunsaturated Fatty Acids: In Vitro Evaluation of Emerging Nanocarriers to Treat Neurodegenerative Diseases.
Hernando S, Herran E, Hernandez RM, Igartua M
Pharmaceutics (2020) 1210: . 234 003 ICC; tested species: rat
Ultrastructural Imaging of Activity-Dependent Synaptic Membrane-Trafficking Events in Cultured Brain Slices.
Imig C, López-Murcia FJ, Maus L, García-Plaza IH, Mortensen LS, Schwark M, Schwarze V, Angibaud J, Nägerl UV, Taschenberger H, Brose N, et al.
Neuron (2020) : . 234 003 IHC; tested species: mouse
Modulation of fear behavior and neuroimmune alterations in house dust mite exposed A/J mice, a model of severe asthma.
Lewkowich I, Ahlbrand R, Johnson E, McAlees J, Nawreen N, Raman R, Lingel I, Hargis J, Hoover C, Sah R
Brain, behavior, and immunity (2020) 88: 688-698. 234 003 IHC; tested species: mouse
Enduring changes in neuronal function upon systemic inflammation are NLRP3 inflammasome dependent.
Beyer MMS, Lonnemann N, Remus A, Latz E, Heneka MT, Korte M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 234 003 IHC; tested species: mouse
Type I Interferon Receptor Signaling in Astrocytes Regulates Hippocampal Synaptic Plasticity and Cognitive Function of the Healthy CNS.
Hosseini S, Michaelsen-Preusse K, Grigoryan G, Chhatbar C, Kalinke U, Korte M
Cell reports (2020) 317: 107666. 234 003 IHC; tested species: mouse
Non-radial tortuous migration with cell polarity alterations of newly generated granule neurons in the neonatal rat dentate gyrus.
Namba T, Shinohara H, Seki T
Brain structure & function (2019) : . 234 003 IHC; tested species: rat
p75NTR regulates brain mononuclear cell function and neuronal structure in Toxoplasma infection-induced neuroinflammation.
Düsedau HP, Kleveman J, Figueiredo CA, Biswas A, Steffen J, Kliche S, Haak S, Zagrebelsky M, Korte M, Dunay IR
Glia (2019) 671: 193-211. 234 003 IHC; tested species: mouse
Co-inhibition of PGF and VEGF blocks their expression in mononuclear phagocytes and limits neovascularization and leakage in the murine retina.
Balser C, Wolf A, Herb M, Langmann T
Journal of neuroinflammation (2019) 161: 26. 234 003 IHC; tested species: mouse
Attenuation of epileptogenesis by 2-deoxy-d-glucose is accompanied by increased cerebral glucose supply, microglial activation and reduced astrocytosis.
Leiter I, Bascuñana P, Bengel FM, Bankstahl JP, Bankstahl M
Neurobiology of disease (2019) : 104510. 234 003 IHC; tested species: mouse
P2Y13 receptors regulate microglial morphology, surveillance, and resting levels of interleukin 1β release.
Kyrargyri V, Madry C, Rifat A, Arancibia-Carcamo IL, Jones SP, Chan VTT, Xu Y, Robaye B, Attwell D
Glia (2019) : . 234 003 IHC; tested species: mouse
TIP60/KAT5 is required for neuronal viability in hippocampal CA1.
Urban I, Kerimoglu C, Sakib MS, Wang H, Benito E, Thaller C, Zhou X, Yan J, Fischer A, Eichele G
Scientific reports (2019) 91: 16173. 234 003 IHC; tested species: mouse
The voltage-gated calcium channel CaV1.2 promotes adult oligodendrocyte progenitor cell survival in the mouse corpus callosum but not motor cortex.
Pitman KA, Ricci R, Gasperini R, Beasley S, Pavez M, Charlesworth J, Foa L, Young KM
Glia (2019) : . 234 003 IHC; tested species: mouse
Changes in spinal cord stiffness in the course of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis.
Pyka-Fościak G, Zemła J, Lis GJ, Litwin JA, Lekka M
Archives of biochemistry and biophysics (2019) : 108221. 234 003 IHC; tested species: mouse
Occurrence of Transmembrane Protein 119 in the Retina is Not Restricted to the Microglia: An Immunohistochemical Study.
Su N, März S, Plagemann T, Cao J, Schnittler HJ, Eter N, Heiduschka P
Translational vision science & technology (2019) 86: 29. 234 003 IHC; tested species: mouse
Chronic near lifetime toluene exposure in rodents does not replicate solvent abuse leukoencephalopathy in humans.
Ranson MA, Del Bigio MR
Neurotoxicology (2018) : . 234 003 IHC; tested species: rat
AAV5-miHTT Gene Therapy Demonstrates Broad Distribution and Strong Human Mutant Huntingtin Lowering in a Huntington's Disease Minipig Model.
Evers MM, Miniarikova J, Juhas S, Vallès A, Bohuslavova B, Juhasova J, Skalnikova HK, Vodicka P, Valekova I, Brouwers C, Blits B, et al.
Molecular therapy : the journal of the American Society of Gene Therapy (2018) 269: 2163-2177. 234 003 IHC; tested species: pig
Long-Term Neuroinflammation Induced by Influenza A Virus Infection and the Impact on Hippocampal Neuron Morphology and Function.
Hosseini S, Wilk E, Michaelsen-Preusse K, Gerhauser I, Baumgärtner W, Geffers R, Schughart K, Korte M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3812: 3060-3080. 234 003 IHC; tested species: mouse
Immunohistochemical analysis of spinal cord components in mouse model of experimental autoimmune encephalomyelitis.
Pyka-Fosciak G, Stasiolek M, Litwin JA
Folia histochemica et cytobiologica (2018) 563: 151-158. 234 003 IHC; tested species: mouse
Beneficial effects of n-3 polyunsaturated fatty acids administration in a partial lesion model of Parkinson's disease: The role of glia and NRf2 regulation.
Hernando S, Requejo C, Herran E, Ruiz-Ortega JA, Morera-Herreras T, Lafuente JV, Ugedo L, Gainza E, Pedraz JL, Igartua M, Hernández RM, et al.
Neurobiology of disease (2018) : . 234 003 IHC; tested species: rat
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1.
Quiñones M, Al-Massadi O, Folgueira C, Bremser S, Gallego R, Torres-Leal L, Haddad-Tóvolli R, García-Caceres C, Hernandez-Bautista R, Lam BYH, Beiroa D, et al.
Nature communications (2018) 91: 3432. 234 003 IHC; tested species: mouse
Deficiency of leptin receptor in myeloid cells disrupts hypothalamic metabolic circuits and causes body weight increase.
Gao Y, Vidal-Itriago A, Milanova I, Korpel NL, Kalsbeek MJ, Tom RZ, Kalsbeek A, Hofmann SM, Yi CX
Molecular metabolism (2018) 7: 155-160. 234 003 IHC; tested species: mouse
Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition.
Richter MC, Ludewig S, Winschel A, Abel T, Bold C, Salzburger LR, Klein S, Han K, Weyer SW, Fritz AK, Laube B, et al.
The EMBO journal (2018) : . 234 003 WB, IHC; tested species: mouse
Effects of the ecto-ATPase apyrase on microglial ramification and surveillance reflect cell depolarization, not ATP depletion.
Madry C, Arancibia-Cárcamo IL, Kyrargyri V, Chan VTT, Hamilton NB, Attwell D
Proceedings of the National Academy of Sciences of the United States of America (2018) 1157: E1608-E1617. 234 003 IHC; tested species: rat
Widespread transduction of astrocytes and neurons in the mouse central nervous system after systemic delivery of a self-complementary AAV-PHP.B vector.
Rincon MY, de Vin F, Duqué SI, Fripont S, Castaldo SA, Bouhuijzen-Wenger J, Holt MG
Gene therapy (2018) : . 234 003 IHC; tested species: mouse
Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+Channel THIK-1.
Madry C, Kyrargyri V, Arancibia-Cárcamo IL, Jolivet R, Kohsaka S, Bryan RM, Attwell D
Neuron (2018) 972: 299-312.e6. 234 003 IHC; tested species: mouse
Optic tract injury after closed head traumatic brain injury in mice: A model of indirect traumatic optic neuropathy.
Evanson NK, Guilhaume-Correa F, Herman JP, Goodman MD
PloS one (2018) 135: e0197346. 234 003 IHC; tested species: mouse
Ablation of peri-insult generated granule cells after epilepsy onset halts disease progression.
Hosford BE, Rowley S, Liska JP, Danzer SC
Scientific reports (2017) 71: 18015. 234 003 IHC; tested species: rat
Dietary sugars, not lipids, drive hypothalamic inflammation.
Gao Y, Bielohuby M, Fleming T, Grabner GF, Foppen E, Bernhard W, Guzmán-Ruiz M, Layritz C, Legutko B, Zinser E, García-Cáceres C, et al.
Molecular metabolism (2017) 68: 897-908. 234 003 IHC
Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity.
Quarta C, Clemmensen C, Zhu Z, Yang B, Joseph SS, Lutter D, Yi CX, Graf E, García-Cáceres C, Legutko B, Fischer K, et al.
Cell metabolism (2017) 264: 620-632.e6. 234 003 IHC; tested species: mouse
Neurovascular Specifications in the Alzheimer-Like Brain of Mice Affected by Focal Cerebral Ischemia: Implications for Future Therapies.
Michalski D, Hofmann S, Pitsch R, Grosche J, Härtig W
Journal of Alzheimer's disease : JAD (2017) 592: 655-674. 234 003 IHC; tested species: mouse
TNFα drives mitochondrial stress in POMC neurons in obesity.
Yi CX, Walter M, Gao Y, Pitra S, Legutko B, Kälin S, Layritz C, García-Cáceres C, Bielohuby M, Bidlingmaier M, Woods SC, et al.
Nature communications (2017) 8: 15143. 234 003 IHC; tested species: mouse
An immunoaffinity-based method for isolating ultrapure adult astrocytes based on ATP1B2 targeting by the ACSA-2 antibody.
Batiuk MY, de Vin F, Duqué SI, Li C, Saito T, Saido T, Fiers M, Belgard TG, Holt MG
The Journal of biological chemistry (2017) 29221: 8874-8891. 234 003 IHC; tested species: mouse
Delayed histochemical alterations within the neurovascular unit due to transient focal cerebral ischemia and experimental treatment with neurotrophic factors.
Michalski D, Pitsch R, Pillai DR, Mages B, Aleithe S, Grosche J, Martens H, Schlachetzki F, Härtig W
PloS one (2017) 124: e0174996. 234 003 IHC
Impact of rapamycin on status epilepticus induced hippocampal pathology and weight gain.
Hester MS, Hosford BE, Santos VR, Singh SP, Rolle IJ, LaSarge CL, Liska JP, Garcia-Cairasco N, Danzer SC
Experimental neurology (2016) 280: 1-12. 234 003 IHC; tested species: mouse
Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1.
Kurhade C, Zegenhagen L, Weber E, Nair S, Michaelsen-Preusse K, Spanier J, Gekara NO, Kröger A, Överby AK
Journal of neuroinflammation (2016) 13: 22. 234 003 IHC
Ablation of Newly Generated Hippocampal Granule Cells Has Disease-Modifying Effects in Epilepsy.
Hosford BE, Liska JP, Danzer SC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2016) 3643: 11013-11023. 234 003 IHC; tested species: mouse
Microglial Acid Sensing Regulates Carbon Dioxide-Evoked Fear.
Vollmer LL, Ghosal S, McGuire JL, Ahlbrand RL, Li KY, Santin JM, Ratliff-Rang CA, Patrone LG, Rush J, Lewkowich IP, Herman JP, et al.
Biological psychiatry (2016) 807: 541-51. 234 003 IHC; tested species: mouse
L-type Calcium Channel Cav1.2 Is Required for Maintenance of Auditory Brainstem Nuclei.
Ebbers L, Satheesh SV, Janz K, Rüttiger L, Blosa M, Hofmann F, Morawski M, Griesemer D, Knipper M, Friauf E, Nothwang HG, et al.
The Journal of biological chemistry (2015) 29039: 23692-710. 234 003 IHC
Interferon regulatory factor-1 protects from fatal neurotropic infection with vesicular stomatitis virus by specific inhibition of viral replication in neurons.
Nair S, Michaelsen-Preusse K, Finsterbusch K, Stegemann-Koniszewski S, Bruder D, Grashoff M, Korte M, Köster M, Kalinke U, Hauser H, Kröger A, et al.
PLoS pathogens (2014) 103: e1003999. 234 003 IHC; tested species: mouse
Capillary pericytes regulate cerebral blood flow in health and disease.
Hall CN, Reynell C, Gesslein B, Hamilton NB, Mishra A, Sutherland BA, O'Farrell FM, Buchan AM, Lauritzen M, Attwell D
Nature (2014) 5087494: 55-60. 234 003 IHC; tested species: mouse
A highly secreted sulphamidase engineered to cross the blood-brain barrier corrects brain lesions of mice with mucopolysaccharidoses type IIIA.
Sorrentino NC, D'Orsi L, Sambri I, Nusco E, Monaco C, Spampanato C, Polishchuk E, Saccone P, De Leonibus E, Ballabio A, Fraldi A, et al.
EMBO molecular medicine (2013) 55: 675-90. 234 003 IHC; tested species: mouse
Pre- and post-shunting observations in adult sheep with kaolin-induced hydrocephalus.
Johnston MG, Del Bigio MR, Drake JM, Armstrong D, Di Curzio DL, Bertrand J
Fluids and barriers of the CNS (2013) 10: 24. 234 003 IHC; tested species: sheep
No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease.
Hillmann A, Hahn S, Schilling S, Hoffmann T, Demuth HU, Bulic B, Schneider-Axmann T, Bayer TA, Weggen S, Wirths O
Neurobiology of aging (2012) 334: 833.e39-50. 234 003 IHC; tested species: mouse
Coping with AIDS: issues of accountability in the dental office.
Cutler LS
Journal - Connecticut State Dental Association (1988) 621: 20-2. 234 003 IHC; tested species: mouse
Blood-Brain Barrier Leakage during Early Epileptogenesis Is Associated with Rapid Remodeling of the Neurovascular Unit.
Bankstahl M, Breuer H, Leiter I, Märkel M, Bascuñana P, Michalski D, Bengel FM, Löscher W, Meier M, Bankstahl JP, Härtig W, et al.
eNeuro () 53: . 234 003 IHC; tested species: rat
The impact of antidiabetic treatment on human hypothalamic infundibular neurons and microglia.
Kalsbeek MJ, Wolff SE, Korpel NL, la Fleur SE, Romijn JA, Fliers E, Kalsbeek A, Swaab DF, Huitinga I, Hol EM, Yi CX, et al.
JCI insight (2020) 516: . 234 003 IHC-P; tested species: human
Memantine treatment of juvenile rats with kaolin-induced hydrocephalus.
Di Curzio DL, Nagra G, Mao X, Del Bigio MR
Brain research (2018) 1689: 54-62. 234 003 IHC-P; tested species: rat
Cerebral white matter oxidation and nitrosylation in young rodents with kaolin-induced hydrocephalus.
Del Bigio MR, Khan OH, da Silva Lopes L, Juliet PA
Journal of neuropathology and experimental neurology (2012) 714: 274-88. 234 003 IHC-P; tested species: rat
Cat. No.: 234 003
Quantity: 50 µg
Price: 370.00 €
Destructive Effect of Intravitreal Heat Shock Protein 27 Application on Retinal Ganglion Cells and Neurofilament.
Grotegut P, Kuehn S, Dick HB, Joachim SC
International journal of molecular sciences (2020) 212: . 234 003 WB; tested species: rat
Intravitreal S100B Injection Triggers a Time-Dependent Microglia Response in a Pro-Inflammatory Manner in Retina and Optic Nerve.
Grotegut P, Kuehn S, Meißner W, Dick HB, Joachim SC
Molecular neurobiology (2019) : . 234 003 WB; tested species: rat
High fat diet treatment impairs hippocampal long-term potentiation without alterations of the core neuropathological features of Alzheimer disease.
Salas IH, Weerasekera A, Ahmed T, Callaerts-Vegh Z, Himmelreich U, D'Hooge R, Balschun D, Saido TC, De Strooper B, Dotti CG
Neurobiology of disease (2018) 113: 82-96. 234 003 WB; tested species: mouse
Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition.
Richter MC, Ludewig S, Winschel A, Abel T, Bold C, Salzburger LR, Klein S, Han K, Weyer SW, Fritz AK, Laube B, et al.
The EMBO journal (2018) : . 234 003 WB, IHC; tested species: mouse
Interaction of complement system and microglia activation in retina and optic nerve in a NMDA damage model.
Kuehn S, Reinehr S, Stute G, Rodust C, Grotegut P, Hensel AT, Burkhard Dick H, Joachim SC
Molecular and cellular neurosciences (2018) : . 234 003 WB; tested species: mouse
Nanostructured Lipid Carriers Made of Ω-3 Polyunsaturated Fatty Acids: In Vitro Evaluation of Emerging Nanocarriers to Treat Neurodegenerative Diseases.
Hernando S, Herran E, Hernandez RM, Igartua M
Pharmaceutics (2020) 1210: . 234 003 ICC; tested species: rat
Ultrastructural Imaging of Activity-Dependent Synaptic Membrane-Trafficking Events in Cultured Brain Slices.
Imig C, López-Murcia FJ, Maus L, García-Plaza IH, Mortensen LS, Schwark M, Schwarze V, Angibaud J, Nägerl UV, Taschenberger H, Brose N, et al.
Neuron (2020) : . 234 003 IHC; tested species: mouse
Modulation of fear behavior and neuroimmune alterations in house dust mite exposed A/J mice, a model of severe asthma.
Lewkowich I, Ahlbrand R, Johnson E, McAlees J, Nawreen N, Raman R, Lingel I, Hargis J, Hoover C, Sah R
Brain, behavior, and immunity (2020) 88: 688-698. 234 003 IHC; tested species: mouse
Enduring changes in neuronal function upon systemic inflammation are NLRP3 inflammasome dependent.
Beyer MMS, Lonnemann N, Remus A, Latz E, Heneka MT, Korte M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 234 003 IHC; tested species: mouse
Type I Interferon Receptor Signaling in Astrocytes Regulates Hippocampal Synaptic Plasticity and Cognitive Function of the Healthy CNS.
Hosseini S, Michaelsen-Preusse K, Grigoryan G, Chhatbar C, Kalinke U, Korte M
Cell reports (2020) 317: 107666. 234 003 IHC; tested species: mouse
Non-radial tortuous migration with cell polarity alterations of newly generated granule neurons in the neonatal rat dentate gyrus.
Namba T, Shinohara H, Seki T
Brain structure & function (2019) : . 234 003 IHC; tested species: rat
p75NTR regulates brain mononuclear cell function and neuronal structure in Toxoplasma infection-induced neuroinflammation.
Düsedau HP, Kleveman J, Figueiredo CA, Biswas A, Steffen J, Kliche S, Haak S, Zagrebelsky M, Korte M, Dunay IR
Glia (2019) 671: 193-211. 234 003 IHC; tested species: mouse
Co-inhibition of PGF and VEGF blocks their expression in mononuclear phagocytes and limits neovascularization and leakage in the murine retina.
Balser C, Wolf A, Herb M, Langmann T
Journal of neuroinflammation (2019) 161: 26. 234 003 IHC; tested species: mouse
Attenuation of epileptogenesis by 2-deoxy-d-glucose is accompanied by increased cerebral glucose supply, microglial activation and reduced astrocytosis.
Leiter I, Bascuñana P, Bengel FM, Bankstahl JP, Bankstahl M
Neurobiology of disease (2019) : 104510. 234 003 IHC; tested species: mouse
P2Y13 receptors regulate microglial morphology, surveillance, and resting levels of interleukin 1β release.
Kyrargyri V, Madry C, Rifat A, Arancibia-Carcamo IL, Jones SP, Chan VTT, Xu Y, Robaye B, Attwell D
Glia (2019) : . 234 003 IHC; tested species: mouse
TIP60/KAT5 is required for neuronal viability in hippocampal CA1.
Urban I, Kerimoglu C, Sakib MS, Wang H, Benito E, Thaller C, Zhou X, Yan J, Fischer A, Eichele G
Scientific reports (2019) 91: 16173. 234 003 IHC; tested species: mouse
The voltage-gated calcium channel CaV1.2 promotes adult oligodendrocyte progenitor cell survival in the mouse corpus callosum but not motor cortex.
Pitman KA, Ricci R, Gasperini R, Beasley S, Pavez M, Charlesworth J, Foa L, Young KM
Glia (2019) : . 234 003 IHC; tested species: mouse
Changes in spinal cord stiffness in the course of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis.
Pyka-Fościak G, Zemła J, Lis GJ, Litwin JA, Lekka M
Archives of biochemistry and biophysics (2019) : 108221. 234 003 IHC; tested species: mouse
Occurrence of Transmembrane Protein 119 in the Retina is Not Restricted to the Microglia: An Immunohistochemical Study.
Su N, März S, Plagemann T, Cao J, Schnittler HJ, Eter N, Heiduschka P
Translational vision science & technology (2019) 86: 29. 234 003 IHC; tested species: mouse
Chronic near lifetime toluene exposure in rodents does not replicate solvent abuse leukoencephalopathy in humans.
Ranson MA, Del Bigio MR
Neurotoxicology (2018) : . 234 003 IHC; tested species: rat
AAV5-miHTT Gene Therapy Demonstrates Broad Distribution and Strong Human Mutant Huntingtin Lowering in a Huntington's Disease Minipig Model.
Evers MM, Miniarikova J, Juhas S, Vallès A, Bohuslavova B, Juhasova J, Skalnikova HK, Vodicka P, Valekova I, Brouwers C, Blits B, et al.
Molecular therapy : the journal of the American Society of Gene Therapy (2018) 269: 2163-2177. 234 003 IHC; tested species: pig
Long-Term Neuroinflammation Induced by Influenza A Virus Infection and the Impact on Hippocampal Neuron Morphology and Function.
Hosseini S, Wilk E, Michaelsen-Preusse K, Gerhauser I, Baumgärtner W, Geffers R, Schughart K, Korte M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3812: 3060-3080. 234 003 IHC; tested species: mouse
Immunohistochemical analysis of spinal cord components in mouse model of experimental autoimmune encephalomyelitis.
Pyka-Fosciak G, Stasiolek M, Litwin JA
Folia histochemica et cytobiologica (2018) 563: 151-158. 234 003 IHC; tested species: mouse
Beneficial effects of n-3 polyunsaturated fatty acids administration in a partial lesion model of Parkinson's disease: The role of glia and NRf2 regulation.
Hernando S, Requejo C, Herran E, Ruiz-Ortega JA, Morera-Herreras T, Lafuente JV, Ugedo L, Gainza E, Pedraz JL, Igartua M, Hernández RM, et al.
Neurobiology of disease (2018) : . 234 003 IHC; tested species: rat
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1.
Quiñones M, Al-Massadi O, Folgueira C, Bremser S, Gallego R, Torres-Leal L, Haddad-Tóvolli R, García-Caceres C, Hernandez-Bautista R, Lam BYH, Beiroa D, et al.
Nature communications (2018) 91: 3432. 234 003 IHC; tested species: mouse
Deficiency of leptin receptor in myeloid cells disrupts hypothalamic metabolic circuits and causes body weight increase.
Gao Y, Vidal-Itriago A, Milanova I, Korpel NL, Kalsbeek MJ, Tom RZ, Kalsbeek A, Hofmann SM, Yi CX
Molecular metabolism (2018) 7: 155-160. 234 003 IHC; tested species: mouse
Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition.
Richter MC, Ludewig S, Winschel A, Abel T, Bold C, Salzburger LR, Klein S, Han K, Weyer SW, Fritz AK, Laube B, et al.
The EMBO journal (2018) : . 234 003 WB, IHC; tested species: mouse
Effects of the ecto-ATPase apyrase on microglial ramification and surveillance reflect cell depolarization, not ATP depletion.
Madry C, Arancibia-Cárcamo IL, Kyrargyri V, Chan VTT, Hamilton NB, Attwell D
Proceedings of the National Academy of Sciences of the United States of America (2018) 1157: E1608-E1617. 234 003 IHC; tested species: rat
Widespread transduction of astrocytes and neurons in the mouse central nervous system after systemic delivery of a self-complementary AAV-PHP.B vector.
Rincon MY, de Vin F, Duqué SI, Fripont S, Castaldo SA, Bouhuijzen-Wenger J, Holt MG
Gene therapy (2018) : . 234 003 IHC; tested species: mouse
Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+Channel THIK-1.
Madry C, Kyrargyri V, Arancibia-Cárcamo IL, Jolivet R, Kohsaka S, Bryan RM, Attwell D
Neuron (2018) 972: 299-312.e6. 234 003 IHC; tested species: mouse
Optic tract injury after closed head traumatic brain injury in mice: A model of indirect traumatic optic neuropathy.
Evanson NK, Guilhaume-Correa F, Herman JP, Goodman MD
PloS one (2018) 135: e0197346. 234 003 IHC; tested species: mouse
Ablation of peri-insult generated granule cells after epilepsy onset halts disease progression.
Hosford BE, Rowley S, Liska JP, Danzer SC
Scientific reports (2017) 71: 18015. 234 003 IHC; tested species: rat
Dietary sugars, not lipids, drive hypothalamic inflammation.
Gao Y, Bielohuby M, Fleming T, Grabner GF, Foppen E, Bernhard W, Guzmán-Ruiz M, Layritz C, Legutko B, Zinser E, García-Cáceres C, et al.
Molecular metabolism (2017) 68: 897-908. 234 003 IHC
Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity.
Quarta C, Clemmensen C, Zhu Z, Yang B, Joseph SS, Lutter D, Yi CX, Graf E, García-Cáceres C, Legutko B, Fischer K, et al.
Cell metabolism (2017) 264: 620-632.e6. 234 003 IHC; tested species: mouse
Neurovascular Specifications in the Alzheimer-Like Brain of Mice Affected by Focal Cerebral Ischemia: Implications for Future Therapies.
Michalski D, Hofmann S, Pitsch R, Grosche J, Härtig W
Journal of Alzheimer's disease : JAD (2017) 592: 655-674. 234 003 IHC; tested species: mouse
TNFα drives mitochondrial stress in POMC neurons in obesity.
Yi CX, Walter M, Gao Y, Pitra S, Legutko B, Kälin S, Layritz C, García-Cáceres C, Bielohuby M, Bidlingmaier M, Woods SC, et al.
Nature communications (2017) 8: 15143. 234 003 IHC; tested species: mouse
An immunoaffinity-based method for isolating ultrapure adult astrocytes based on ATP1B2 targeting by the ACSA-2 antibody.
Batiuk MY, de Vin F, Duqué SI, Li C, Saito T, Saido T, Fiers M, Belgard TG, Holt MG
The Journal of biological chemistry (2017) 29221: 8874-8891. 234 003 IHC; tested species: mouse
Delayed histochemical alterations within the neurovascular unit due to transient focal cerebral ischemia and experimental treatment with neurotrophic factors.
Michalski D, Pitsch R, Pillai DR, Mages B, Aleithe S, Grosche J, Martens H, Schlachetzki F, Härtig W
PloS one (2017) 124: e0174996. 234 003 IHC
Impact of rapamycin on status epilepticus induced hippocampal pathology and weight gain.
Hester MS, Hosford BE, Santos VR, Singh SP, Rolle IJ, LaSarge CL, Liska JP, Garcia-Cairasco N, Danzer SC
Experimental neurology (2016) 280: 1-12. 234 003 IHC; tested species: mouse
Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1.
Kurhade C, Zegenhagen L, Weber E, Nair S, Michaelsen-Preusse K, Spanier J, Gekara NO, Kröger A, Överby AK
Journal of neuroinflammation (2016) 13: 22. 234 003 IHC
Ablation of Newly Generated Hippocampal Granule Cells Has Disease-Modifying Effects in Epilepsy.
Hosford BE, Liska JP, Danzer SC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2016) 3643: 11013-11023. 234 003 IHC; tested species: mouse
Microglial Acid Sensing Regulates Carbon Dioxide-Evoked Fear.
Vollmer LL, Ghosal S, McGuire JL, Ahlbrand RL, Li KY, Santin JM, Ratliff-Rang CA, Patrone LG, Rush J, Lewkowich IP, Herman JP, et al.
Biological psychiatry (2016) 807: 541-51. 234 003 IHC; tested species: mouse
L-type Calcium Channel Cav1.2 Is Required for Maintenance of Auditory Brainstem Nuclei.
Ebbers L, Satheesh SV, Janz K, Rüttiger L, Blosa M, Hofmann F, Morawski M, Griesemer D, Knipper M, Friauf E, Nothwang HG, et al.
The Journal of biological chemistry (2015) 29039: 23692-710. 234 003 IHC
Interferon regulatory factor-1 protects from fatal neurotropic infection with vesicular stomatitis virus by specific inhibition of viral replication in neurons.
Nair S, Michaelsen-Preusse K, Finsterbusch K, Stegemann-Koniszewski S, Bruder D, Grashoff M, Korte M, Köster M, Kalinke U, Hauser H, Kröger A, et al.
PLoS pathogens (2014) 103: e1003999. 234 003 IHC; tested species: mouse
Capillary pericytes regulate cerebral blood flow in health and disease.
Hall CN, Reynell C, Gesslein B, Hamilton NB, Mishra A, Sutherland BA, O'Farrell FM, Buchan AM, Lauritzen M, Attwell D
Nature (2014) 5087494: 55-60. 234 003 IHC; tested species: mouse
A highly secreted sulphamidase engineered to cross the blood-brain barrier corrects brain lesions of mice with mucopolysaccharidoses type IIIA.
Sorrentino NC, D'Orsi L, Sambri I, Nusco E, Monaco C, Spampanato C, Polishchuk E, Saccone P, De Leonibus E, Ballabio A, Fraldi A, et al.
EMBO molecular medicine (2013) 55: 675-90. 234 003 IHC; tested species: mouse
Pre- and post-shunting observations in adult sheep with kaolin-induced hydrocephalus.
Johnston MG, Del Bigio MR, Drake JM, Armstrong D, Di Curzio DL, Bertrand J
Fluids and barriers of the CNS (2013) 10: 24. 234 003 IHC; tested species: sheep
No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease.
Hillmann A, Hahn S, Schilling S, Hoffmann T, Demuth HU, Bulic B, Schneider-Axmann T, Bayer TA, Weggen S, Wirths O
Neurobiology of aging (2012) 334: 833.e39-50. 234 003 IHC; tested species: mouse
Coping with AIDS: issues of accountability in the dental office.
Cutler LS
Journal - Connecticut State Dental Association (1988) 621: 20-2. 234 003 IHC; tested species: mouse
Blood-Brain Barrier Leakage during Early Epileptogenesis Is Associated with Rapid Remodeling of the Neurovascular Unit.
Bankstahl M, Breuer H, Leiter I, Märkel M, Bascuñana P, Michalski D, Bengel FM, Löscher W, Meier M, Bankstahl JP, Härtig W, et al.
eNeuro () 53: . 234 003 IHC; tested species: rat
The impact of antidiabetic treatment on human hypothalamic infundibular neurons and microglia.
Kalsbeek MJ, Wolff SE, Korpel NL, la Fleur SE, Romijn JA, Fliers E, Kalsbeek A, Swaab DF, Huitinga I, Hol EM, Yi CX, et al.
JCI insight (2020) 516: . 234 003 IHC-P; tested species: human
Memantine treatment of juvenile rats with kaolin-induced hydrocephalus.
Di Curzio DL, Nagra G, Mao X, Del Bigio MR
Brain research (2018) 1689: 54-62. 234 003 IHC-P; tested species: rat
Cerebral white matter oxidation and nitrosylation in young rodents with kaolin-induced hydrocephalus.
Del Bigio MR, Khan OH, da Silva Lopes L, Juliet PA
Journal of neuropathology and experimental neurology (2012) 714: 274-88. 234 003 IHC-P; tested species: rat
Background

Ionized calcium-binding adaptor molecule 1 (IBA1) or allograft inflammatory factor1 (AIF-1) is an EF hand calcium binding protein which is expressed by cells of the monocyte/macrophage lineage and by germ cells in the testis (1). In mice, IBA1/AIF-1 can be regarded a “pan-macrophage marker” because, except for alveolar macrophages, all subpopulations of macrophages express IBA1/AIF-1 (1). In human gliomas IBA1 defines a distinct subset of tumor-associated activated macrophages/microglial cells (2).
Microglia represent the resident macrophages in the nervous system and are the smallest of the glial cells with cell bodies of only 2-5 µm in diameter. In the CNS IBA1 upregulation is associated with neuroinflammatory response (3).