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Home > Products > 106 011

Synapsin1 antibody - 106 011 K.O.

Synapsins are peripheral synaptic vesicle proteins and substrate for several protein kinases
Mouse monoclonal purified IgG
Cat. No.: 106 011
Amount: 100 µg
Price: $435.00
Cat. No. 106 011 100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 up to 1 : 10000 (AP staining) gallery  
IP: yes
ICC: 1 : 100 up to 1 : 2000 gallery  
IHC: 1 : 500 up to 1 : 1000 gallery  
IHC-P: 1 : 200 gallery  
DNA-PAINT: yes
EM: yes
ELISA: yes (see remarks)
Clone 46.1
Subtype IgG1
Immunogen full-length recombinant rat Synapsin1 (UniProt Id: P09951)
Epitop AA 435 to 475 from rat Synapsin1 (UniProt Id: P09951)
Reactivity Reacts with: human (P17600), rat (P09951), mouse (O88935), mammals.
Weaker signal: zebrafish, chicken, other vertebrates.
Other species not tested yet.
Specificity Specific for synapsin 1a and 1b independent of phosphorylation state. K.O. validated
Remarks

ELISA: Suitable as capture antibody for sandwich-ELISA with cat. no. 106 002 as detector antibody. The ELISA-protocol for membrane proteins is recommended.
Data sheet 106_011.pdf

References for Synapsin1 - 106 011

Adult-onset deactivation of autophagy leads to loss of synapse homeostasis and cognitive impairment, with implications for alzheimer disease.
Grosso Jasutkar H, Wasserlein EM, Ishola A, Litt N, Staniszewski A, Arancio O, Yamamoto A
Autophagy (2024) : 1-16. 106 011 WB; tested species: mouse
The lncRNA Malat1 is trafficked to the cytoplasm as a localized mRNA encoding a small peptide in neurons.
Xiao W, Halabi R, Lin CH, Nazim M, Yeom KH, Black DL
Genes & development (2024) : . 106 011 WB; tested species: mouse
CSF1R-mediated myeloid cell depletion shifts the ratio of motor cortical excitatory to inhibitory neurons in a multiple system atrophy model.
Gauer C, Battis K, Schneider Y, Florio JB, Mante M, Kim HY, Rissman RA, Hoffmann A, Winkler J
Experimental neurology (2024) 374: 114706. 106 011 WB; tested species: mouse
Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice.
Monsorno K, Ginggen K, Ivanov A, Buckinx A, Lalive AL, Tchenio A, Benson S, Vendrell M, D'Alessandro A, Beule D, Pellerin L, et al.
Nature communications (2023) 141: 5749. 106 011 WB; tested species: mouse
Developmental Pb exposure increases AD risk via altered intracellular Ca2+ homeostasis in hiPSC-derived cortical neurons.
Xie J, Wu S, Szadowski H, Min S, Yang Y, Bowman AB, Rochet JC, Freeman JL, Yuan C
The Journal of biological chemistry (2023) : 105023. 106 011 WB, ICC; tested species: human
Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons.
Goldsmith J, Ordureau A, Harper JW, Holzbaur ELF
Neuron (2022) 1106: 967-976.e8. 106 011 WB; tested species: human
Bassoon controls synaptic vesicle release via regulation of presynaptic phosphorylation and cAMP.
Montenegro-Venegas C, Guhathakurta D, Pina-Fernandez E, Andres-Alonso M, Plattner F, Gundelfinger ED, Fejtova A
EMBO reports (2022) 238: e53659. 106 011 WB; tested species: mouse
De Novo Missense Variants in SLC32A1 Cause a Developmental and Epileptic Encephalopathy Due to Impaired GABAergic Neurotransmission.
Platzer K, Sticht H, Bupp C, Ganapathi M, Pereira EM, Le Guyader G, Bilan F, Henderson LB, Lemke JR, Taschenberger H, Brose N, et al.
Annals of neurology (2022) : . 106 011 WB; tested species: mouse
Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly.
Conde-Dusman MJ, Dey PN, Elía-Zudaire Ó, Rabaneda LG, García-Lira C, Grand T, Briz V, Velasco ER, Andero R, Niñerola S, Barco A, et al.
eLife (2021) 10: . 106 011 WB; tested species: rat
The Different Molecular Code in Generation of Dopaminergic Neurons from Astrocytes and Mesenchymal Stem Cells.
Wang N, Ji X, Wu Y, Zhou S, Peng H, Wang J, Yu S, Zhang J
International journal of molecular sciences (2021) 2222: . 106 011 WB; tested species: rat
Munc13-1 is a Ca2+-phospholipid-dependent vesicle priming hub that shapes synaptic short-term plasticity and enables sustained neurotransmission.
Lipstein N, Chang S, Lin KH, López-Murcia FJ, Neher E, Taschenberger H, Brose N
Neuron (2021) : . 106 011 WB; tested species: mouse
The phosphoprotein Synapsin Ia regulates the kinetics of dense-core vesicle release.
Yang HJ, Chen PC, Huang CT, Cheng TL, Hsu SP, Chen CY, Lu JC, Wang CT
The Journal of neuroscience : the official journal of the Society for Neuroscience (2021) : . 106 011 WB; tested species: rat
Selective disruption of inhibitory synapses leading to neuronal hyperexcitability at an early stage of tau pathogenesis in a mouse model.
Shimojo M, Takuwa H, Takado Y, Tokunaga M, Tsukamoto S, Minatohara K, Ono M, Seki C, Maeda J, Urushihata T, Minamihisamatsu T, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 106 011 WB, ICC; tested species: mouse
Certain ortho-hydroxylated brominated ethers are promiscuous kinase inhibitors that impair neuronal signaling and neurodevelopmental processes.
Poston RG, Murphy L, Rejepova A, Ghaninejad-Esfahani M, Segales J, Mulligan K, Saha RN
The Journal of biological chemistry (2020) : . 106 011 WB; tested species: rat
Latrophilin-2 and latrophilin-3 are redundantly essential for parallel-fiber synapse function in cerebellum.
Zhang RS, Liakath-Ali K, Südhof TC
eLife (2020) 9: . 106 011 WB; tested species: mouse
Vesicle Clustering in a Living Synapse Depends on a Synapsin Region that Mediates Phase Separation.
Pechstein A, Tomilin N, Fredrich K, Vorontsova O, Sopova E, Evergren E, Haucke V, Brodin L, Shupliakov O
Cell reports (2020) 308: 2594-2602.e3. 106 011 WB
CYP46A1 Activation by Efavirenz Leads to Behavioral Improvement without Significant Changes in Amyloid Plaque Load in the Brain of 5XFAD Mice.
Petrov AM, Lam M, Mast N, Moon J, Li Y, Maxfield E, Pikuleva IA
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics (2019) : . 106 011 WB; tested species: mouse
Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts.
Raja MK, Preobraschenski J, Del Olmo-Cabrera S, Martinez-Turrillas R, Jahn R, Perez-Otano I, Wesseling JF
eLife (2019) 8: . 106 011 WB; tested species: mouse
The Calmodulin Binding Region of the Synaptic Vesicle Protein Mover Is Required for Homomeric Interaction and Presynaptic Targeting.
Akula AK, Zhang X, Viotti JS, Nestvogel D, Rhee JS, Ebrecht R, Reim K, Wouters F, Liepold T, Jahn O, Bogeski I, et al.
Frontiers in molecular neuroscience (2019) 12: 249. 106 011 WB, ICC; tested species: mouse
Identification of a Core Amino Acid Motif within the α Subunit of GABAARs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures.
Nathanson AJ, Zhang Y, Smalley JL, Ollerhead TA, Rodriguez Santos MA, Andrews PM, Wobst HJ, Moore YE, Brandon NJ, Hines RM, Davies PA, et al.
Cell reports (2019) 283: 670-681.e8. 106 011 WB; tested species: mouse
Neuronal Activity Drives Astroglial Connexin 30 in Perisynaptic Processes and Shapes Its Functions.
Ghézali G, Vasile F, Curry N, Fantham M, Cheung G, Ezan P, Cohen-Salmon M, Kaminski C, Rouach N
Cerebral cortex (New York, N.Y. : 1991) (2019) : . 106 011 WB; tested species: mouse
Connexin 30 controls astroglial polarization during postnatal brain development.
Ghézali G, Calvo CF, Pillet LE, Llense F, Ezan P, Pannasch U, Bemelmans AP, Etienne Manneville S, Rouach N
Development (Cambridge, England) (2018) 1454: . 106 011 WB; tested species: mouse
Sustained consumption of cocoa-based dark chocolate enhances seizure-like events in the mouse hippocampus.
Cicvaric A, Bulat T, Bormann D, Yang J, Auer B, Milenkovic I, Cabatic M, Milicevic R, Monje FJ
Food & function (2018) 93: 1532-1544. 106 011 WB; tested species: mouse
RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.
Grauel MK, Maglione M, Reddy-Alla S, Willmes CG, Brockmann MM, Trimbuch T, Rosenmund T, Pangalos M, Vardar G, Stumpf A, Walter AM, et al.
Proceedings of the National Academy of Sciences of the United States of America (2016) 11341: 11615-11620. 106 011 WB; tested species: mouse
Synaptic control of mRNA translation by reversible assembly of XRN1 bodies.
Luchelli L, Thomas MG, Boccaccio GL
Journal of cell science (2015) 1288: 1542-54. 106 011 ICC, WB
Point mutation in syntaxin-1A causes abnormal vesicle recycling, behaviors, and short term plasticity.
Watanabe Y, Katayama N, Takeuchi K, Togano T, Itoh R, Sato M, Yamazaki M, Abe M, Sato T, Oda K, Yokoyama M, et al.
The Journal of biological chemistry (2013) 28848: 34906-19. 106 011 WB; tested species: mouse
Tyrosine phosphorylation regulates the endocytosis and surface expression of GluN3A-containing NMDA receptors.
Chowdhury D, Marco S, Brooks IM, Zandueta A, Rao Y, Haucke V, Wesseling JF, Tavalin SJ, Pérez-Otaño I
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 339: 4151-64. 106 011 WB
Working memory impairment in calcineurin knock-out mice is associated with alterations in synaptic vesicle cycling and disruption of high-frequency synaptic and network activity in prefrontal cortex.
Cottrell JR, Levenson JM, Kim SH, Gibson HE, Richardson KA, Sivula M, Li B, Ashford CJ, Heindl KA, Babcock RJ, Rose DM, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3327: 10938-49. 106 011 WB; tested species: mouse
Mover is a homomeric phospho-protein present on synaptic vesicles.
Ahmed S, Wittenmayer N, Kremer T, Hoeber J, Kiran Akula A, Urlaub H, Islinger M, Kirsch J, Dean C, Dresbach T
PloS one (2013) 85: e63474. 106 011 WB
Bacterial cytolysin during meningitis disrupts the regulation of glutamate in the brain, leading to synaptic damage.
Wippel C, Maurer J, Förtsch C, Hupp S, Bohl A, Ma J, Mitchell TJ, Bunkowski S, Brück W, Nau R, Iliev AI, et al.
PLoS pathogens (2013) 96: e1003380. 106 011 IHC, WB; tested species: mouse
RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13.
Deng L, Kaeser PS, Xu W, Südhof TC
Neuron (2011) 692: 317-31. 106 011 ICC, WB; tested species: mouse
Suppression of guanylyl cyclase (beta1 subunit) expression impairs neurite outgrowth and synapse maturation in cultured cerebellar granule cells.
López-Jiménez ME, Bartolomé-Martín D, Sánchez-Prieto J, Torres M
Cell death and differentiation (2009) 169: 1266-78. 106 011 ICC, WB; tested species: rat
LRRTM2 controls presynapse nano-organization and AMPA receptor sub-positioning through Neurexin-binding interface.
Liouta K, Lubas M, Venugopal V, Chabbert J, Jeannière C, Diaz C, Munier M, Tessier B, Claverol S, Favereaux A, Sainlos M, et al.
Nature communications (2024) 151: 8807. 106 011 ICC; tested species: mouse
Developmental neurotoxicity of PFOA exposure on hiPSC-derived cortical neurons.
Wu S, Xie J, Zhao H, Zhao X, Sánchez OF, Rochet JC, Freeman JL, Yuan C
Environment international (2024) 190: 108914. 106 011 ICC; tested species: human
Real-time visualization of structural dynamics of synapses in live cells in vivo.
Son S, Nagahama K, Lee J, Jung K, Kwak C, Kim J, Noh YW, Kim E, Lee S, Kwon HB, Heo WD, et al.
Nature methods (2024) : . 106 011 ICC; tested species: rat
Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity.
Barone I, Gilette NM, Hawks-Mayer H, Handy J, Zhang KJ, Chifamba FF, Mostafa E, Johnson-Venkatesh EM, Sun Y, Gibson JM, Rotenberg A, et al.
Science advances (2023) 943: eadj1010. 106 011 ICC; tested species: mouse
Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons.
Popova D, Gameiro-Ros I, Youssef MM, Zalamea P, Morris AD, Prytkova I, Jadali A, Kwan KY, Kamarajan C, Salvatore JE, Xuei X, et al.
Molecular psychiatry (2023) 282: 746-758. 106 011 ICC; tested species: human
Developmental Pb exposure increases AD risk via altered intracellular Ca2+ homeostasis in hiPSC-derived cortical neurons.
Xie J, Wu S, Szadowski H, Min S, Yang Y, Bowman AB, Rochet JC, Freeman JL, Yuan C
The Journal of biological chemistry (2023) : 105023. 106 011 WB, ICC; tested species: human
A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells.
Jovanovic VM, Weber C, Slamecka J, Ryu S, Chu PH, Sen C, Inman J, De Sousa JF, Barnaeva E, Hirst M, Galbraith D, et al.
Stem cell reports (2023) : . 106 011 ICC; tested species: mouse
Regulation of synaptic connectivity in schizophrenia spectrum by mutual neuron-microglia interaction.
Breitmeyer R, Vogel S, Heider J, Hartmann SM, Wüst R, Keller AL, Binner A, Fitzgerald JC, Fallgatter AJ, Volkmer H
Communications biology (2023) 61: 472. 106 011 ICC; tested species: human
Modeling native and seeded Synuclein aggregation and related cellular dysfunctions in dopaminergic neurons derived by a new set of isogenic iPSC lines with SNCA multiplications.
Iannielli A, Luoni M, Giannelli SG, Ferese R, Ordazzo G, Fossati M, Raimondi A, Opazo F, Corti O, Prehn JHM, Gambardella S, et al.
Cell death & disease (2022) 1310: 881. 106 011 ICC; tested species: human
Establishment of Neurotoxicity Assessment Using Microelectrode Array (MEA) with hiPSC-Derived Neurons and Evaluation of New Psychoactive Substances (NPS).
Kang KR, Kim CY, Kim J, Ryu B, Lee SG, Baek J, Kim YJ, Lee JM, Lee Y, Choi SO, Woo DH, et al.
International journal of stem cells (2022) : . 106 011 ICC; tested species: human
α-Synuclein induced cholesterol lowering increases tonic and reduces depolarization-evoked synaptic vesicle recycling and glutamate release.
Lazarevic V, Yang Y, Paslawski W, Svenningsson P
NPJ Parkinson's disease (2022) 81: 71. 106 011 ICC; tested species: mouse
Secreted Amyloid Precursor Protein-Alpha Enhances LTP Through the Synthesis and Trafficking of Ca2+-Permeable AMPA Receptors.
Livingstone RW, Elder MK, Singh A, Westlake CM, Tate WP, Abraham WC, Williams JM
Frontiers in molecular neuroscience (2021) 14: 660208. 106 011 ICC; tested species: rat
Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum.
Kuijpers M, Kochlamazashvili G, Stumpf A, Puchkov D, Swaminathan A, Lucht MT, Krause E, Maritzen T, Schmitz D, Haucke V
Neuron (2021) 1092: 299-313.e9. 106 011 ICC; tested species: mouse
Interneuronal exchange and functional integration of synaptobrevin via extracellular vesicles.
Vilcaes AA, Chanaday NL, Kavalali ET
Neuron (2021) 1096: 971-983.e5. 106 011 ICC; tested species: mouse,rat
A photoswitchable GPCR-based opsin for presynaptic inhibition.
Copits BA, Gowrishankar R, O'Neill PR, Li JN, Girven KS, Yoo JJ, Meshik X, Parker KE, Spangler SM, Elerding AJ, Brown BJ, et al.
Neuron (2021) 10911: 1791-1809.e11. 106 011 ICC; tested species: mouse
Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress.
Chanaday NL, Nosyreva E, Shin OH, Zhang H, Aklan I, Atasoy D, Bezprozvanny I, Kavalali ET
Neuron (2021) 1098: 1314-1332.e5. 106 011 ICC; tested species: rat
The potassium channel subunit Kvβ1 serves as a major control point for synaptic facilitation.
Cho IH, Panzera LC, Chin M, Alpizar SA, Olveda GE, Hill RA, Hoppa MB
Proceedings of the National Academy of Sciences of the United States of America (2020) 11747: 29937-29947. 106 011 ICC; tested species: rat
Alternative splicing at neuroligin site A regulates glycan interaction and synaptogenic activity.
Oku S, Feng H, Connor S, Toledo A, Zhang P, Zhang Y, Thoumine O, Zhang C, Craig AM
eLife (2020) 9: . 106 011 ICC; tested species: rat
Selected Ionotropic Receptors and Voltage-Gated Ion Channels: More Functional Competence for Human Induced Pluripotent Stem Cell (iPSC)-Derived Nociceptors.
Schoepf CL, Zeidler M, Spiecker L, Kern G, Lechner J, Kummer KK, Kress M
Brain sciences (2020) 106: . 106 011 ICC; tested species: human
Selective disruption of inhibitory synapses leading to neuronal hyperexcitability at an early stage of tau pathogenesis in a mouse model.
Shimojo M, Takuwa H, Takado Y, Tokunaga M, Tsukamoto S, Minatohara K, Ono M, Seki C, Maeda J, Urushihata T, Minamihisamatsu T, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 106 011 WB, ICC; tested species: mouse
Microglia Mediate HIV-1 gp120-Induced Synaptic Degeneration in Spinal Pain Neural Circuits.
Ru W, Liu X, Bae C, Shi Y, Walikonis R, Mo Chung J, Tang SJ
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) 3942: 8408-8421. 106 011 ICC, IHC; tested species: mouse
Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons.
Livingstone RW, Elder MK, Barrett MC, Westlake CM, Peppercorn K, Tate WP, Abraham WC, Williams JM
Frontiers in molecular neuroscience (2019) 12: 198. 106 011 ICC; tested species: rat
Presynaptic α2δ-2 Calcium Channel Subunits Regulate Postsynaptic GABAA Receptor Abundance and Axonal Wiring.
Geisler S, Schöpf CL, Stanika R, Kalb M, Campiglio M, Repetto D, Traxler L, Missler M, Obermair GJ
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) 3914: 2581-2605. 106 011 ICC; tested species: mouse
The Calmodulin Binding Region of the Synaptic Vesicle Protein Mover Is Required for Homomeric Interaction and Presynaptic Targeting.
Akula AK, Zhang X, Viotti JS, Nestvogel D, Rhee JS, Ebrecht R, Reim K, Wouters F, Liepold T, Jahn O, Bogeski I, et al.
Frontiers in molecular neuroscience (2019) 12: 249. 106 011 WB, ICC; tested species: mouse
Activity-Dependent Nucleation of Dynamic Microtubules at Presynaptic Boutons Controls Neurotransmission.
Qu X, Kumar A, Blockus H, Waites C, Bartolini F
Current biology : CB (2019) : . 106 011 ICC; tested species: rat
Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs. isogenic control.
Ghatak S, Dolatabadi N, Trudler D, Zhang X, Wu Y, Mohata M, Ambasudhan R, Talantova M, Lipton SA
eLife (2019) 8: . 106 011 ICC; tested species: human
Astrocytic miR-324-5p is essential for synaptic formation by suppressing the secretion of CCL5 from astrocytes.
Sun C, Zhu L, Ma R, Ren J, Wang J, Gao S, Yang D, Ning K, Ling B, Lu B, Chen X, et al.
Cell death & disease (2019) 102: 141. 106 011 ICC, IHC; tested species: mouse
Robust Induced Presynapse on Artificial Substrate as a Neural Interfacing Method.
Jeon J, Oh MA, Cho W, Yoon SH, Kim JY, Chung TD
ACS applied materials & interfaces (2019) : . 106 011 ICC; tested species: rat
Identification of Embryonic Neural Plate Border Stem Cells and Their Generation by Direct Reprogramming from Adult Human Blood Cells.
Thier MC, Hommerding O, Panten J, Pinna R, García-González D, Berger T, Wörsdörfer P, Assenov Y, Scognamiglio R, Przybylla A, Kaschutnig P, et al.
Cell stem cell (2018) : . 106 011 ICC; tested species: human
Epitope specificity of anti-synapsin autoantibodies: Differential targeting of synapsin I domains.
Mertens R, Melchert S, Gitler D, Schou MB, Saether SG, Vaaler A, Piepgras J, Kochova E, Benfenati F, Ahnert-Hilger G, Ruprecht K, et al.
PloS one (2018) 1312: e0208636. 106 011 ICC; tested species: human
A Chemical Recipe for Generation of Clinical-Grade Striatal Neurons from hESCs.
Wu M, Zhang D, Bi C, Mi T, Zhu W, Xia L, Teng Z, Hu B, Wu Y
Stem cell reports (2018) : . 106 011 ICC; tested species: human
Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins.
Elegheert J, Cvetkovska V, Clayton AJ, Heroven C, Vennekens KM, Smukowski SN, Regan MC, Jia W, Smith AC, Furukawa H, Savas JN, et al.
Neuron (2017) 961: 242-244. 106 011 ICC; tested species: mouse
Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins.
Elegheert J, Cvetkovska V, Clayton AJ, Heroven C, Vennekens KM, Smukowski SN, Regan MC, Jia W, Smith AC, Furukawa H, Savas JN, et al.
Neuron (2017) 954: 896-913.e10. 106 011 ICC
Identification of Protein Tyrosine Phosphatase Receptor Type O (PTPRO) as a Synaptic Adhesion Molecule that Promotes Synapse Formation.
Jiang W, Wei M, Liu M, Pan Y, Cao D, Yang X, Zhang C
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 3741: 9828-9843. 106 011 ICC
Dynamic Partitioning of Synaptic Vesicle Pools by the SNARE-Binding Protein Tomosyn.
Cazares VA, Njus MM, Manly A, Saldate JJ, Subramani A, Ben-Simon Y, Sutton MA, Ashery U, Stuenkel EL
The Journal of neuroscience : the official journal of the Society for Neuroscience (2016) 3644: 11208-11222. 106 011 ICC; tested species: rat
Negative regulation of microRNA-132 in expression of synaptic proteins in neuronal differentiation of embryonic neural stem cells.
Yoshimura A, Numakawa T, Odaka H, Adachi N, Tamai Y, Kunugi H
Neurochemistry international (2016) 97: 26-33. 106 011 ICC
Revisiting adult neurogenesis and the role of erythropoietin for neuronal and oligodendroglial differentiation in the hippocampus.
Hassouna I, Ott C, Wüstefeld L, Offen N, Neher RA, Mitkovski M, Winkler D, Sperling S, Fries L, Goebbels S, Vreja IC, et al.
Molecular psychiatry (2016) 2112: 1752-1767. 106 011 ICC
Thrombospondin-4 and excitatory synaptogenesis promote spinal sensitization after painful mechanical joint injury.
Crosby ND, Zaucke F, Kras JV, Dong L, Luo ZD, Winkelstein BA
Experimental neurology (2015) 264: 111-20. 106 011 ICC
Synaptic control of mRNA translation by reversible assembly of XRN1 bodies.
Luchelli L, Thomas MG, Boccaccio GL
Journal of cell science (2015) 1288: 1542-54. 106 011 ICC, WB
Evaluation of established human iPSC-derived neurons to model neurodegenerative diseases.
Meneghello G, Verheyen A, Van Ingen M, Kuijlaars J, Tuefferd M, Van Den Wyngaert I, Nuydens R
Neuroscience (2015) 301: 204-12. 106 011 ICC; tested species: human
The Susd2 protein regulates neurite growth and excitatory synaptic density in hippocampal cultures.
Nadjar Y, Triller A, Bessereau JL, Dumoulin A
Molecular and cellular neurosciences (2015) 65: 82-91. 106 011 ICC
BDNF enhances spontaneous and activity-dependent neurotransmitter release at excitatory terminals but not at inhibitory terminals in hippocampal neurons.
Shinoda Y, Ahmed S, Ramachandran B, Bharat V, Brockelt D, Altas B, Dean C
Frontiers in synaptic neuroscience (2014) 6: 27. 106 011 ICC; tested species: rat
Neural progenitors derived from human induced pluripotent stem cells survive and differentiate upon transplantation into a rat model of amyotrophic lateral sclerosis.
Popescu IR, Nicaise C, Liu S, Bisch G, Knippenberg S, Daubie V, Bohl D, Pochet R
Stem cells translational medicine (2013) 23: 167-74. 106 011 ICC; tested species: human
Impaired spatial memory in mice lacking CD3ζ is associated with altered NMDA and AMPA receptors signaling independent of T-cell deficiency.
Louveau A, Angibaud J, Haspot F, Opazo MC, Thinard R, Thepenier V, Baudouin SJ, Lescaudron L, Hulin P, Riedel CA, Boudin H, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3347: 18672-85. 106 011 ICC; tested species: mouse
SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients.
Shcheglovitov A, Shcheglovitova O, Yazawa M, Portmann T, Shu R, Sebastiano V, Krawisz A, Froehlich W, Bernstein JA, Hallmayer JF, Dolmetsch RE, et al.
Nature (2013) 5037475: 267-71. 106 011 ICC; tested species: human
Inhibition of exocytosis or endocytosis blocks activity-dependent redistribution of synapsin.
Orenbuch A, Ayelet O, Shulman Y, Yoav S, Lipstein N, Noa L, Bechar A, Amit B, Lavy Y, Yotam L, Brumer E, et al.
Journal of neurochemistry (2012) 1202: 248-58. 106 011 ICC; tested species: mouse
Postsynaptic TrkC and presynaptic PTPσ function as a bidirectional excitatory synaptic organizing complex.
Takahashi H, Arstikaitis P, Prasad T, Bartlett TE, Wang YT, Murphy TH, Craig AM
Neuron (2011) 692: 287-303. 106 011 ICC; tested species: rat
RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13.
Deng L, Kaeser PS, Xu W, Südhof TC
Neuron (2011) 692: 317-31. 106 011 ICC, WB; tested species: mouse
Neurexin-neuroligin adhesions capture surface-diffusing AMPA receptors through PSD-95 scaffolds.
Mondin M, Labrousse V, Hosy E, Heine M, Tessier B, Levet F, Poujol C, Blanchet C, Choquet D, Thoumine O
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3138: 13500-15. 106 011 ICC
Suppression of guanylyl cyclase (beta1 subunit) expression impairs neurite outgrowth and synapse maturation in cultured cerebellar granule cells.
López-Jiménez ME, Bartolomé-Martín D, Sánchez-Prieto J, Torres M
Cell death and differentiation (2009) 169: 1266-78. 106 011 ICC, WB; tested species: rat
Induction of GABAergic postsynaptic differentiation by alpha-neurexins.
Kang Y, Zhang X, Dobie F, Wu H, Craig AM
The Journal of biological chemistry (2008) 2834: 2323-34. 106 011 ICC; tested species: rat
Immunolocalization of BK channels in hippocampal pyramidal neurons.
Sailer CA, Kaufmann WA, Kogler M, Chen L, Sausbier U, Ottersen OP, Ruth P, Shipston MJ, Knaus HG
The European journal of neuroscience (2006) 242: 442-54. 106 011 ICC; tested species: mouse
Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: interference by cholinesterase inhibitors.
Schwab K, Lauer D, Magbagbeolu M, Theuring F, Gasiorowska A, Zadrozny M, Harrington CR, Wischik CM, Niewiadomska G, Riedel G
Brain research bulletin (2024) : 110955. 106 011 IHC; tested species: mouse
Integrated proteogenomic characterization of glioblastoma evolution.
Kim KH, Migliozzi S, Koo H, Hong JH, Park SM, Kim S, Kwon HJ, Ha S, Garofano L, Oh YT, D'Angelo F, et al.
Cancer cell (2024) 423: 358-377.e8. 106 011 IHC; tested species: mouse
A neural hub for holistic courtship displays.
Ben-Tov M, Duarte F, Mooney R
Current biology : CB (2023) : . 106 011 IHC
Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulated in Exercise in a Mouse Model of Parkinson's Disease.
Tong W, Zhang K, Yao H, Li L, Hu Y, Zhang J, Song Y, Guan Q, Li S, Sun YE, Jin L, et al.
Frontiers in aging neuroscience (2022) 14: 891644. 106 011 IHC; tested species: mouse
A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies.
Kang Y, Zhou Y, Li Y, Han Y, Xu J, Niu W, Li Z, Liu S, Feng H, Huang W, Duan R, et al.
Nature neuroscience (2021) 2410: 1377-1391. 106 011 IHC; tested species: human
Expression Pattern of ALOXE3 in Mouse Brain Suggests Its Relationship with Seizure Susceptibility.
Tang HL, Chen SY, Zhang H, Lu P, Sun WW, Gao MM, Zeng XD, Su T, Long YS
Cellular and molecular neurobiology (2020) : . 106 011 IHC; tested species: mouse
Compensatory neuritogenesis of serotonergic afferents within the striatum of a transgenic rat model of Parkinson's disease.
Stemick J, Gauer C, Wihan J, Moceri S, Xiang W, von Hörsten S, Kohl Z, Winkler J
Brain research (2020) 1748: 147119. 106 011 IHC; tested species: rat
Astrocytic miR-324-5p is essential for synaptic formation by suppressing the secretion of CCL5 from astrocytes.
Sun C, Zhu L, Ma R, Ren J, Wang J, Gao S, Yang D, Ning K, Ling B, Lu B, Chen X, et al.
Cell death & disease (2019) 102: 141. 106 011 ICC, IHC; tested species: mouse
Functional organization of vestibulospinal inputs on thoracic motoneurons responsible for trunk postural control in Xenopus.
Olechowski-Bessaguet A, Grandemange R, Cardoit L, Courty E, Lambert FM, Ray DL
The Journal of physiology (2019) : . 106 011 IHC; tested species: frog
Microglia Mediate HIV-1 gp120-Induced Synaptic Degeneration in Spinal Pain Neural Circuits.
Ru W, Liu X, Bae C, Shi Y, Walikonis R, Mo Chung J, Tang SJ
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) 3942: 8408-8421. 106 011 ICC, IHC; tested species: mouse
Long-Range GABAergic Inputs Regulate Neural Stem Cell Quiescence and Control Adult Hippocampal Neurogenesis.
Bao H, Asrican B, Li W, Gu B, Wen Z, Lim SA, Haniff I, Ramakrishnan C, Deisseroth K, Philpot B, Song J, et al.
Cell stem cell (2017) 215: 604-617.e5. 106 011 IHC; tested species: mouse
Regulation of hippocampal synaptic strength by glial xCT.
Williams LE, Featherstone DE
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3448: 16093-102. 106 011 IHC; tested species: mouse
Bacterial cytolysin during meningitis disrupts the regulation of glutamate in the brain, leading to synaptic damage.
Wippel C, Maurer J, Förtsch C, Hupp S, Bohl A, Ma J, Mitchell TJ, Bunkowski S, Brück W, Nau R, Iliev AI, et al.
PLoS pathogens (2013) 96: e1003380. 106 011 IHC, WB; tested species: mouse
Evidence for anterograde transport and transcytosis of botulinum neurotoxin A (BoNT/A).
Restani L, Antonucci F, Gianfranceschi L, Rossi C, Rossetto O, Caleo M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3144: 15650-9. 106 011 IHC; tested species: rat
A synaptic molecular dependency network in knockdown of autism- and schizophrenia-associated genes revealed by multiplexed imaging.
Falkovich R, Danielson EW, Perez de Arce K, Wamhoff EC, Strother J, Lapteva AP, Sheng M, Cottrell JR, Bathe M
Cell reports (2023) 425: 112430. 106 011 DNA-PAINT; tested species: rat
Immunogold labeling of synaptic vesicle proteins in developing hippocampal neurons.
Tao-Cheng JH
Molecular brain (2020) 131: 9. 106 011 EM; tested species: rat
Optimization of an autaptic culture system for studying cholinergic synapses in sympathetic ganglia.
Kang SJ, Nguyen HS, Lee CK, Kim S, Rhee JS, Jeong SW
Pflugers Archiv : European journal of physiology (2024) : . 106 011
Mechanical coupling between transsynaptic N-cadherin adhesions and actin flow stabilizes dendritic spines.
Chazeau A, Garcia M, Czöndör K, Perrais D, Tessier B, Giannone G, Thoumine O
Molecular biology of the cell (2015) 265: 859-73. 106 011
Cat. No.: 106 011
Amount: 100 µg
Price: $435.00
Adult-onset deactivation of autophagy leads to loss of synapse homeostasis and cognitive impairment, with implications for alzheimer disease.
Grosso Jasutkar H, Wasserlein EM, Ishola A, Litt N, Staniszewski A, Arancio O, Yamamoto A
Autophagy (2024) : 1-16. 106 011 WB; tested species: mouse
The lncRNA Malat1 is trafficked to the cytoplasm as a localized mRNA encoding a small peptide in neurons.
Xiao W, Halabi R, Lin CH, Nazim M, Yeom KH, Black DL
Genes & development (2024) : . 106 011 WB; tested species: mouse
CSF1R-mediated myeloid cell depletion shifts the ratio of motor cortical excitatory to inhibitory neurons in a multiple system atrophy model.
Gauer C, Battis K, Schneider Y, Florio JB, Mante M, Kim HY, Rissman RA, Hoffmann A, Winkler J
Experimental neurology (2024) 374: 114706. 106 011 WB; tested species: mouse
Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice.
Monsorno K, Ginggen K, Ivanov A, Buckinx A, Lalive AL, Tchenio A, Benson S, Vendrell M, D'Alessandro A, Beule D, Pellerin L, et al.
Nature communications (2023) 141: 5749. 106 011 WB; tested species: mouse
Developmental Pb exposure increases AD risk via altered intracellular Ca2+ homeostasis in hiPSC-derived cortical neurons.
Xie J, Wu S, Szadowski H, Min S, Yang Y, Bowman AB, Rochet JC, Freeman JL, Yuan C
The Journal of biological chemistry (2023) : 105023. 106 011 WB, ICC; tested species: human
Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons.
Goldsmith J, Ordureau A, Harper JW, Holzbaur ELF
Neuron (2022) 1106: 967-976.e8. 106 011 WB; tested species: human
Bassoon controls synaptic vesicle release via regulation of presynaptic phosphorylation and cAMP.
Montenegro-Venegas C, Guhathakurta D, Pina-Fernandez E, Andres-Alonso M, Plattner F, Gundelfinger ED, Fejtova A
EMBO reports (2022) 238: e53659. 106 011 WB; tested species: mouse
De Novo Missense Variants in SLC32A1 Cause a Developmental and Epileptic Encephalopathy Due to Impaired GABAergic Neurotransmission.
Platzer K, Sticht H, Bupp C, Ganapathi M, Pereira EM, Le Guyader G, Bilan F, Henderson LB, Lemke JR, Taschenberger H, Brose N, et al.
Annals of neurology (2022) : . 106 011 WB; tested species: mouse
Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly.
Conde-Dusman MJ, Dey PN, Elía-Zudaire Ó, Rabaneda LG, García-Lira C, Grand T, Briz V, Velasco ER, Andero R, Niñerola S, Barco A, et al.
eLife (2021) 10: . 106 011 WB; tested species: rat
The Different Molecular Code in Generation of Dopaminergic Neurons from Astrocytes and Mesenchymal Stem Cells.
Wang N, Ji X, Wu Y, Zhou S, Peng H, Wang J, Yu S, Zhang J
International journal of molecular sciences (2021) 2222: . 106 011 WB; tested species: rat
Munc13-1 is a Ca2+-phospholipid-dependent vesicle priming hub that shapes synaptic short-term plasticity and enables sustained neurotransmission.
Lipstein N, Chang S, Lin KH, López-Murcia FJ, Neher E, Taschenberger H, Brose N
Neuron (2021) : . 106 011 WB; tested species: mouse
The phosphoprotein Synapsin Ia regulates the kinetics of dense-core vesicle release.
Yang HJ, Chen PC, Huang CT, Cheng TL, Hsu SP, Chen CY, Lu JC, Wang CT
The Journal of neuroscience : the official journal of the Society for Neuroscience (2021) : . 106 011 WB; tested species: rat
Selective disruption of inhibitory synapses leading to neuronal hyperexcitability at an early stage of tau pathogenesis in a mouse model.
Shimojo M, Takuwa H, Takado Y, Tokunaga M, Tsukamoto S, Minatohara K, Ono M, Seki C, Maeda J, Urushihata T, Minamihisamatsu T, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 106 011 WB, ICC; tested species: mouse
Certain ortho-hydroxylated brominated ethers are promiscuous kinase inhibitors that impair neuronal signaling and neurodevelopmental processes.
Poston RG, Murphy L, Rejepova A, Ghaninejad-Esfahani M, Segales J, Mulligan K, Saha RN
The Journal of biological chemistry (2020) : . 106 011 WB; tested species: rat
Latrophilin-2 and latrophilin-3 are redundantly essential for parallel-fiber synapse function in cerebellum.
Zhang RS, Liakath-Ali K, Südhof TC
eLife (2020) 9: . 106 011 WB; tested species: mouse
Vesicle Clustering in a Living Synapse Depends on a Synapsin Region that Mediates Phase Separation.
Pechstein A, Tomilin N, Fredrich K, Vorontsova O, Sopova E, Evergren E, Haucke V, Brodin L, Shupliakov O
Cell reports (2020) 308: 2594-2602.e3. 106 011 WB
CYP46A1 Activation by Efavirenz Leads to Behavioral Improvement without Significant Changes in Amyloid Plaque Load in the Brain of 5XFAD Mice.
Petrov AM, Lam M, Mast N, Moon J, Li Y, Maxfield E, Pikuleva IA
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics (2019) : . 106 011 WB; tested species: mouse
Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts.
Raja MK, Preobraschenski J, Del Olmo-Cabrera S, Martinez-Turrillas R, Jahn R, Perez-Otano I, Wesseling JF
eLife (2019) 8: . 106 011 WB; tested species: mouse
The Calmodulin Binding Region of the Synaptic Vesicle Protein Mover Is Required for Homomeric Interaction and Presynaptic Targeting.
Akula AK, Zhang X, Viotti JS, Nestvogel D, Rhee JS, Ebrecht R, Reim K, Wouters F, Liepold T, Jahn O, Bogeski I, et al.
Frontiers in molecular neuroscience (2019) 12: 249. 106 011 WB, ICC; tested species: mouse
Identification of a Core Amino Acid Motif within the α Subunit of GABAARs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures.
Nathanson AJ, Zhang Y, Smalley JL, Ollerhead TA, Rodriguez Santos MA, Andrews PM, Wobst HJ, Moore YE, Brandon NJ, Hines RM, Davies PA, et al.
Cell reports (2019) 283: 670-681.e8. 106 011 WB; tested species: mouse
Neuronal Activity Drives Astroglial Connexin 30 in Perisynaptic Processes and Shapes Its Functions.
Ghézali G, Vasile F, Curry N, Fantham M, Cheung G, Ezan P, Cohen-Salmon M, Kaminski C, Rouach N
Cerebral cortex (New York, N.Y. : 1991) (2019) : . 106 011 WB; tested species: mouse
Connexin 30 controls astroglial polarization during postnatal brain development.
Ghézali G, Calvo CF, Pillet LE, Llense F, Ezan P, Pannasch U, Bemelmans AP, Etienne Manneville S, Rouach N
Development (Cambridge, England) (2018) 1454: . 106 011 WB; tested species: mouse
Sustained consumption of cocoa-based dark chocolate enhances seizure-like events in the mouse hippocampus.
Cicvaric A, Bulat T, Bormann D, Yang J, Auer B, Milenkovic I, Cabatic M, Milicevic R, Monje FJ
Food & function (2018) 93: 1532-1544. 106 011 WB; tested species: mouse
RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.
Grauel MK, Maglione M, Reddy-Alla S, Willmes CG, Brockmann MM, Trimbuch T, Rosenmund T, Pangalos M, Vardar G, Stumpf A, Walter AM, et al.
Proceedings of the National Academy of Sciences of the United States of America (2016) 11341: 11615-11620. 106 011 WB; tested species: mouse
Synaptic control of mRNA translation by reversible assembly of XRN1 bodies.
Luchelli L, Thomas MG, Boccaccio GL
Journal of cell science (2015) 1288: 1542-54. 106 011 ICC, WB
Point mutation in syntaxin-1A causes abnormal vesicle recycling, behaviors, and short term plasticity.
Watanabe Y, Katayama N, Takeuchi K, Togano T, Itoh R, Sato M, Yamazaki M, Abe M, Sato T, Oda K, Yokoyama M, et al.
The Journal of biological chemistry (2013) 28848: 34906-19. 106 011 WB; tested species: mouse
Tyrosine phosphorylation regulates the endocytosis and surface expression of GluN3A-containing NMDA receptors.
Chowdhury D, Marco S, Brooks IM, Zandueta A, Rao Y, Haucke V, Wesseling JF, Tavalin SJ, Pérez-Otaño I
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 339: 4151-64. 106 011 WB
Working memory impairment in calcineurin knock-out mice is associated with alterations in synaptic vesicle cycling and disruption of high-frequency synaptic and network activity in prefrontal cortex.
Cottrell JR, Levenson JM, Kim SH, Gibson HE, Richardson KA, Sivula M, Li B, Ashford CJ, Heindl KA, Babcock RJ, Rose DM, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3327: 10938-49. 106 011 WB; tested species: mouse
Mover is a homomeric phospho-protein present on synaptic vesicles.
Ahmed S, Wittenmayer N, Kremer T, Hoeber J, Kiran Akula A, Urlaub H, Islinger M, Kirsch J, Dean C, Dresbach T
PloS one (2013) 85: e63474. 106 011 WB
Bacterial cytolysin during meningitis disrupts the regulation of glutamate in the brain, leading to synaptic damage.
Wippel C, Maurer J, Förtsch C, Hupp S, Bohl A, Ma J, Mitchell TJ, Bunkowski S, Brück W, Nau R, Iliev AI, et al.
PLoS pathogens (2013) 96: e1003380. 106 011 IHC, WB; tested species: mouse
RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13.
Deng L, Kaeser PS, Xu W, Südhof TC
Neuron (2011) 692: 317-31. 106 011 ICC, WB; tested species: mouse
Suppression of guanylyl cyclase (beta1 subunit) expression impairs neurite outgrowth and synapse maturation in cultured cerebellar granule cells.
López-Jiménez ME, Bartolomé-Martín D, Sánchez-Prieto J, Torres M
Cell death and differentiation (2009) 169: 1266-78. 106 011 ICC, WB; tested species: rat
LRRTM2 controls presynapse nano-organization and AMPA receptor sub-positioning through Neurexin-binding interface.
Liouta K, Lubas M, Venugopal V, Chabbert J, Jeannière C, Diaz C, Munier M, Tessier B, Claverol S, Favereaux A, Sainlos M, et al.
Nature communications (2024) 151: 8807. 106 011 ICC; tested species: mouse
Developmental neurotoxicity of PFOA exposure on hiPSC-derived cortical neurons.
Wu S, Xie J, Zhao H, Zhao X, Sánchez OF, Rochet JC, Freeman JL, Yuan C
Environment international (2024) 190: 108914. 106 011 ICC; tested species: human
Real-time visualization of structural dynamics of synapses in live cells in vivo.
Son S, Nagahama K, Lee J, Jung K, Kwak C, Kim J, Noh YW, Kim E, Lee S, Kwon HB, Heo WD, et al.
Nature methods (2024) : . 106 011 ICC; tested species: rat
Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity.
Barone I, Gilette NM, Hawks-Mayer H, Handy J, Zhang KJ, Chifamba FF, Mostafa E, Johnson-Venkatesh EM, Sun Y, Gibson JM, Rotenberg A, et al.
Science advances (2023) 943: eadj1010. 106 011 ICC; tested species: mouse
Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons.
Popova D, Gameiro-Ros I, Youssef MM, Zalamea P, Morris AD, Prytkova I, Jadali A, Kwan KY, Kamarajan C, Salvatore JE, Xuei X, et al.
Molecular psychiatry (2023) 282: 746-758. 106 011 ICC; tested species: human
Developmental Pb exposure increases AD risk via altered intracellular Ca2+ homeostasis in hiPSC-derived cortical neurons.
Xie J, Wu S, Szadowski H, Min S, Yang Y, Bowman AB, Rochet JC, Freeman JL, Yuan C
The Journal of biological chemistry (2023) : 105023. 106 011 WB, ICC; tested species: human
A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells.
Jovanovic VM, Weber C, Slamecka J, Ryu S, Chu PH, Sen C, Inman J, De Sousa JF, Barnaeva E, Hirst M, Galbraith D, et al.
Stem cell reports (2023) : . 106 011 ICC; tested species: mouse
Regulation of synaptic connectivity in schizophrenia spectrum by mutual neuron-microglia interaction.
Breitmeyer R, Vogel S, Heider J, Hartmann SM, Wüst R, Keller AL, Binner A, Fitzgerald JC, Fallgatter AJ, Volkmer H
Communications biology (2023) 61: 472. 106 011 ICC; tested species: human
Modeling native and seeded Synuclein aggregation and related cellular dysfunctions in dopaminergic neurons derived by a new set of isogenic iPSC lines with SNCA multiplications.
Iannielli A, Luoni M, Giannelli SG, Ferese R, Ordazzo G, Fossati M, Raimondi A, Opazo F, Corti O, Prehn JHM, Gambardella S, et al.
Cell death & disease (2022) 1310: 881. 106 011 ICC; tested species: human
Establishment of Neurotoxicity Assessment Using Microelectrode Array (MEA) with hiPSC-Derived Neurons and Evaluation of New Psychoactive Substances (NPS).
Kang KR, Kim CY, Kim J, Ryu B, Lee SG, Baek J, Kim YJ, Lee JM, Lee Y, Choi SO, Woo DH, et al.
International journal of stem cells (2022) : . 106 011 ICC; tested species: human
α-Synuclein induced cholesterol lowering increases tonic and reduces depolarization-evoked synaptic vesicle recycling and glutamate release.
Lazarevic V, Yang Y, Paslawski W, Svenningsson P
NPJ Parkinson's disease (2022) 81: 71. 106 011 ICC; tested species: mouse
Secreted Amyloid Precursor Protein-Alpha Enhances LTP Through the Synthesis and Trafficking of Ca2+-Permeable AMPA Receptors.
Livingstone RW, Elder MK, Singh A, Westlake CM, Tate WP, Abraham WC, Williams JM
Frontiers in molecular neuroscience (2021) 14: 660208. 106 011 ICC; tested species: rat
Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum.
Kuijpers M, Kochlamazashvili G, Stumpf A, Puchkov D, Swaminathan A, Lucht MT, Krause E, Maritzen T, Schmitz D, Haucke V
Neuron (2021) 1092: 299-313.e9. 106 011 ICC; tested species: mouse
Interneuronal exchange and functional integration of synaptobrevin via extracellular vesicles.
Vilcaes AA, Chanaday NL, Kavalali ET
Neuron (2021) 1096: 971-983.e5. 106 011 ICC; tested species: mouse,rat
A photoswitchable GPCR-based opsin for presynaptic inhibition.
Copits BA, Gowrishankar R, O'Neill PR, Li JN, Girven KS, Yoo JJ, Meshik X, Parker KE, Spangler SM, Elerding AJ, Brown BJ, et al.
Neuron (2021) 10911: 1791-1809.e11. 106 011 ICC; tested species: mouse
Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress.
Chanaday NL, Nosyreva E, Shin OH, Zhang H, Aklan I, Atasoy D, Bezprozvanny I, Kavalali ET
Neuron (2021) 1098: 1314-1332.e5. 106 011 ICC; tested species: rat
The potassium channel subunit Kvβ1 serves as a major control point for synaptic facilitation.
Cho IH, Panzera LC, Chin M, Alpizar SA, Olveda GE, Hill RA, Hoppa MB
Proceedings of the National Academy of Sciences of the United States of America (2020) 11747: 29937-29947. 106 011 ICC; tested species: rat
Alternative splicing at neuroligin site A regulates glycan interaction and synaptogenic activity.
Oku S, Feng H, Connor S, Toledo A, Zhang P, Zhang Y, Thoumine O, Zhang C, Craig AM
eLife (2020) 9: . 106 011 ICC; tested species: rat
Selected Ionotropic Receptors and Voltage-Gated Ion Channels: More Functional Competence for Human Induced Pluripotent Stem Cell (iPSC)-Derived Nociceptors.
Schoepf CL, Zeidler M, Spiecker L, Kern G, Lechner J, Kummer KK, Kress M
Brain sciences (2020) 106: . 106 011 ICC; tested species: human
Selective disruption of inhibitory synapses leading to neuronal hyperexcitability at an early stage of tau pathogenesis in a mouse model.
Shimojo M, Takuwa H, Takado Y, Tokunaga M, Tsukamoto S, Minatohara K, Ono M, Seki C, Maeda J, Urushihata T, Minamihisamatsu T, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 106 011 WB, ICC; tested species: mouse
Microglia Mediate HIV-1 gp120-Induced Synaptic Degeneration in Spinal Pain Neural Circuits.
Ru W, Liu X, Bae C, Shi Y, Walikonis R, Mo Chung J, Tang SJ
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) 3942: 8408-8421. 106 011 ICC, IHC; tested species: mouse
Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons.
Livingstone RW, Elder MK, Barrett MC, Westlake CM, Peppercorn K, Tate WP, Abraham WC, Williams JM
Frontiers in molecular neuroscience (2019) 12: 198. 106 011 ICC; tested species: rat
Presynaptic α2δ-2 Calcium Channel Subunits Regulate Postsynaptic GABAA Receptor Abundance and Axonal Wiring.
Geisler S, Schöpf CL, Stanika R, Kalb M, Campiglio M, Repetto D, Traxler L, Missler M, Obermair GJ
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) 3914: 2581-2605. 106 011 ICC; tested species: mouse
The Calmodulin Binding Region of the Synaptic Vesicle Protein Mover Is Required for Homomeric Interaction and Presynaptic Targeting.
Akula AK, Zhang X, Viotti JS, Nestvogel D, Rhee JS, Ebrecht R, Reim K, Wouters F, Liepold T, Jahn O, Bogeski I, et al.
Frontiers in molecular neuroscience (2019) 12: 249. 106 011 WB, ICC; tested species: mouse
Activity-Dependent Nucleation of Dynamic Microtubules at Presynaptic Boutons Controls Neurotransmission.
Qu X, Kumar A, Blockus H, Waites C, Bartolini F
Current biology : CB (2019) : . 106 011 ICC; tested species: rat
Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs. isogenic control.
Ghatak S, Dolatabadi N, Trudler D, Zhang X, Wu Y, Mohata M, Ambasudhan R, Talantova M, Lipton SA
eLife (2019) 8: . 106 011 ICC; tested species: human
Astrocytic miR-324-5p is essential for synaptic formation by suppressing the secretion of CCL5 from astrocytes.
Sun C, Zhu L, Ma R, Ren J, Wang J, Gao S, Yang D, Ning K, Ling B, Lu B, Chen X, et al.
Cell death & disease (2019) 102: 141. 106 011 ICC, IHC; tested species: mouse
Robust Induced Presynapse on Artificial Substrate as a Neural Interfacing Method.
Jeon J, Oh MA, Cho W, Yoon SH, Kim JY, Chung TD
ACS applied materials & interfaces (2019) : . 106 011 ICC; tested species: rat
Identification of Embryonic Neural Plate Border Stem Cells and Their Generation by Direct Reprogramming from Adult Human Blood Cells.
Thier MC, Hommerding O, Panten J, Pinna R, García-González D, Berger T, Wörsdörfer P, Assenov Y, Scognamiglio R, Przybylla A, Kaschutnig P, et al.
Cell stem cell (2018) : . 106 011 ICC; tested species: human
Epitope specificity of anti-synapsin autoantibodies: Differential targeting of synapsin I domains.
Mertens R, Melchert S, Gitler D, Schou MB, Saether SG, Vaaler A, Piepgras J, Kochova E, Benfenati F, Ahnert-Hilger G, Ruprecht K, et al.
PloS one (2018) 1312: e0208636. 106 011 ICC; tested species: human
A Chemical Recipe for Generation of Clinical-Grade Striatal Neurons from hESCs.
Wu M, Zhang D, Bi C, Mi T, Zhu W, Xia L, Teng Z, Hu B, Wu Y
Stem cell reports (2018) : . 106 011 ICC; tested species: human
Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins.
Elegheert J, Cvetkovska V, Clayton AJ, Heroven C, Vennekens KM, Smukowski SN, Regan MC, Jia W, Smith AC, Furukawa H, Savas JN, et al.
Neuron (2017) 961: 242-244. 106 011 ICC; tested species: mouse
Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins.
Elegheert J, Cvetkovska V, Clayton AJ, Heroven C, Vennekens KM, Smukowski SN, Regan MC, Jia W, Smith AC, Furukawa H, Savas JN, et al.
Neuron (2017) 954: 896-913.e10. 106 011 ICC
Identification of Protein Tyrosine Phosphatase Receptor Type O (PTPRO) as a Synaptic Adhesion Molecule that Promotes Synapse Formation.
Jiang W, Wei M, Liu M, Pan Y, Cao D, Yang X, Zhang C
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 3741: 9828-9843. 106 011 ICC
Dynamic Partitioning of Synaptic Vesicle Pools by the SNARE-Binding Protein Tomosyn.
Cazares VA, Njus MM, Manly A, Saldate JJ, Subramani A, Ben-Simon Y, Sutton MA, Ashery U, Stuenkel EL
The Journal of neuroscience : the official journal of the Society for Neuroscience (2016) 3644: 11208-11222. 106 011 ICC; tested species: rat
Negative regulation of microRNA-132 in expression of synaptic proteins in neuronal differentiation of embryonic neural stem cells.
Yoshimura A, Numakawa T, Odaka H, Adachi N, Tamai Y, Kunugi H
Neurochemistry international (2016) 97: 26-33. 106 011 ICC
Revisiting adult neurogenesis and the role of erythropoietin for neuronal and oligodendroglial differentiation in the hippocampus.
Hassouna I, Ott C, Wüstefeld L, Offen N, Neher RA, Mitkovski M, Winkler D, Sperling S, Fries L, Goebbels S, Vreja IC, et al.
Molecular psychiatry (2016) 2112: 1752-1767. 106 011 ICC
Thrombospondin-4 and excitatory synaptogenesis promote spinal sensitization after painful mechanical joint injury.
Crosby ND, Zaucke F, Kras JV, Dong L, Luo ZD, Winkelstein BA
Experimental neurology (2015) 264: 111-20. 106 011 ICC
Synaptic control of mRNA translation by reversible assembly of XRN1 bodies.
Luchelli L, Thomas MG, Boccaccio GL
Journal of cell science (2015) 1288: 1542-54. 106 011 ICC, WB
Evaluation of established human iPSC-derived neurons to model neurodegenerative diseases.
Meneghello G, Verheyen A, Van Ingen M, Kuijlaars J, Tuefferd M, Van Den Wyngaert I, Nuydens R
Neuroscience (2015) 301: 204-12. 106 011 ICC; tested species: human
The Susd2 protein regulates neurite growth and excitatory synaptic density in hippocampal cultures.
Nadjar Y, Triller A, Bessereau JL, Dumoulin A
Molecular and cellular neurosciences (2015) 65: 82-91. 106 011 ICC
BDNF enhances spontaneous and activity-dependent neurotransmitter release at excitatory terminals but not at inhibitory terminals in hippocampal neurons.
Shinoda Y, Ahmed S, Ramachandran B, Bharat V, Brockelt D, Altas B, Dean C
Frontiers in synaptic neuroscience (2014) 6: 27. 106 011 ICC; tested species: rat
Neural progenitors derived from human induced pluripotent stem cells survive and differentiate upon transplantation into a rat model of amyotrophic lateral sclerosis.
Popescu IR, Nicaise C, Liu S, Bisch G, Knippenberg S, Daubie V, Bohl D, Pochet R
Stem cells translational medicine (2013) 23: 167-74. 106 011 ICC; tested species: human
Impaired spatial memory in mice lacking CD3ζ is associated with altered NMDA and AMPA receptors signaling independent of T-cell deficiency.
Louveau A, Angibaud J, Haspot F, Opazo MC, Thinard R, Thepenier V, Baudouin SJ, Lescaudron L, Hulin P, Riedel CA, Boudin H, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3347: 18672-85. 106 011 ICC; tested species: mouse
SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients.
Shcheglovitov A, Shcheglovitova O, Yazawa M, Portmann T, Shu R, Sebastiano V, Krawisz A, Froehlich W, Bernstein JA, Hallmayer JF, Dolmetsch RE, et al.
Nature (2013) 5037475: 267-71. 106 011 ICC; tested species: human
Inhibition of exocytosis or endocytosis blocks activity-dependent redistribution of synapsin.
Orenbuch A, Ayelet O, Shulman Y, Yoav S, Lipstein N, Noa L, Bechar A, Amit B, Lavy Y, Yotam L, Brumer E, et al.
Journal of neurochemistry (2012) 1202: 248-58. 106 011 ICC; tested species: mouse
Postsynaptic TrkC and presynaptic PTPσ function as a bidirectional excitatory synaptic organizing complex.
Takahashi H, Arstikaitis P, Prasad T, Bartlett TE, Wang YT, Murphy TH, Craig AM
Neuron (2011) 692: 287-303. 106 011 ICC; tested species: rat
RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13.
Deng L, Kaeser PS, Xu W, Südhof TC
Neuron (2011) 692: 317-31. 106 011 ICC, WB; tested species: mouse
Neurexin-neuroligin adhesions capture surface-diffusing AMPA receptors through PSD-95 scaffolds.
Mondin M, Labrousse V, Hosy E, Heine M, Tessier B, Levet F, Poujol C, Blanchet C, Choquet D, Thoumine O
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3138: 13500-15. 106 011 ICC
Suppression of guanylyl cyclase (beta1 subunit) expression impairs neurite outgrowth and synapse maturation in cultured cerebellar granule cells.
López-Jiménez ME, Bartolomé-Martín D, Sánchez-Prieto J, Torres M
Cell death and differentiation (2009) 169: 1266-78. 106 011 ICC, WB; tested species: rat
Induction of GABAergic postsynaptic differentiation by alpha-neurexins.
Kang Y, Zhang X, Dobie F, Wu H, Craig AM
The Journal of biological chemistry (2008) 2834: 2323-34. 106 011 ICC; tested species: rat
Immunolocalization of BK channels in hippocampal pyramidal neurons.
Sailer CA, Kaufmann WA, Kogler M, Chen L, Sausbier U, Ottersen OP, Ruth P, Shipston MJ, Knaus HG
The European journal of neuroscience (2006) 242: 442-54. 106 011 ICC; tested species: mouse
Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: interference by cholinesterase inhibitors.
Schwab K, Lauer D, Magbagbeolu M, Theuring F, Gasiorowska A, Zadrozny M, Harrington CR, Wischik CM, Niewiadomska G, Riedel G
Brain research bulletin (2024) : 110955. 106 011 IHC; tested species: mouse
Integrated proteogenomic characterization of glioblastoma evolution.
Kim KH, Migliozzi S, Koo H, Hong JH, Park SM, Kim S, Kwon HJ, Ha S, Garofano L, Oh YT, D'Angelo F, et al.
Cancer cell (2024) 423: 358-377.e8. 106 011 IHC; tested species: mouse
A neural hub for holistic courtship displays.
Ben-Tov M, Duarte F, Mooney R
Current biology : CB (2023) : . 106 011 IHC
Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulated in Exercise in a Mouse Model of Parkinson's Disease.
Tong W, Zhang K, Yao H, Li L, Hu Y, Zhang J, Song Y, Guan Q, Li S, Sun YE, Jin L, et al.
Frontiers in aging neuroscience (2022) 14: 891644. 106 011 IHC; tested species: mouse
A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies.
Kang Y, Zhou Y, Li Y, Han Y, Xu J, Niu W, Li Z, Liu S, Feng H, Huang W, Duan R, et al.
Nature neuroscience (2021) 2410: 1377-1391. 106 011 IHC; tested species: human
Expression Pattern of ALOXE3 in Mouse Brain Suggests Its Relationship with Seizure Susceptibility.
Tang HL, Chen SY, Zhang H, Lu P, Sun WW, Gao MM, Zeng XD, Su T, Long YS
Cellular and molecular neurobiology (2020) : . 106 011 IHC; tested species: mouse
Compensatory neuritogenesis of serotonergic afferents within the striatum of a transgenic rat model of Parkinson's disease.
Stemick J, Gauer C, Wihan J, Moceri S, Xiang W, von Hörsten S, Kohl Z, Winkler J
Brain research (2020) 1748: 147119. 106 011 IHC; tested species: rat
Astrocytic miR-324-5p is essential for synaptic formation by suppressing the secretion of CCL5 from astrocytes.
Sun C, Zhu L, Ma R, Ren J, Wang J, Gao S, Yang D, Ning K, Ling B, Lu B, Chen X, et al.
Cell death & disease (2019) 102: 141. 106 011 ICC, IHC; tested species: mouse
Functional organization of vestibulospinal inputs on thoracic motoneurons responsible for trunk postural control in Xenopus.
Olechowski-Bessaguet A, Grandemange R, Cardoit L, Courty E, Lambert FM, Ray DL
The Journal of physiology (2019) : . 106 011 IHC; tested species: frog
Microglia Mediate HIV-1 gp120-Induced Synaptic Degeneration in Spinal Pain Neural Circuits.
Ru W, Liu X, Bae C, Shi Y, Walikonis R, Mo Chung J, Tang SJ
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) 3942: 8408-8421. 106 011 ICC, IHC; tested species: mouse
Long-Range GABAergic Inputs Regulate Neural Stem Cell Quiescence and Control Adult Hippocampal Neurogenesis.
Bao H, Asrican B, Li W, Gu B, Wen Z, Lim SA, Haniff I, Ramakrishnan C, Deisseroth K, Philpot B, Song J, et al.
Cell stem cell (2017) 215: 604-617.e5. 106 011 IHC; tested species: mouse
Regulation of hippocampal synaptic strength by glial xCT.
Williams LE, Featherstone DE
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3448: 16093-102. 106 011 IHC; tested species: mouse
Bacterial cytolysin during meningitis disrupts the regulation of glutamate in the brain, leading to synaptic damage.
Wippel C, Maurer J, Förtsch C, Hupp S, Bohl A, Ma J, Mitchell TJ, Bunkowski S, Brück W, Nau R, Iliev AI, et al.
PLoS pathogens (2013) 96: e1003380. 106 011 IHC, WB; tested species: mouse
Evidence for anterograde transport and transcytosis of botulinum neurotoxin A (BoNT/A).
Restani L, Antonucci F, Gianfranceschi L, Rossi C, Rossetto O, Caleo M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3144: 15650-9. 106 011 IHC; tested species: rat
A synaptic molecular dependency network in knockdown of autism- and schizophrenia-associated genes revealed by multiplexed imaging.
Falkovich R, Danielson EW, Perez de Arce K, Wamhoff EC, Strother J, Lapteva AP, Sheng M, Cottrell JR, Bathe M
Cell reports (2023) 425: 112430. 106 011 DNA-PAINT; tested species: rat
Immunogold labeling of synaptic vesicle proteins in developing hippocampal neurons.
Tao-Cheng JH
Molecular brain (2020) 131: 9. 106 011 EM; tested species: rat
Optimization of an autaptic culture system for studying cholinergic synapses in sympathetic ganglia.
Kang SJ, Nguyen HS, Lee CK, Kim S, Rhee JS, Jeong SW
Pflugers Archiv : European journal of physiology (2024) : . 106 011
Mechanical coupling between transsynaptic N-cadherin adhesions and actin flow stabilizes dendritic spines.
Chazeau A, Garcia M, Czöndör K, Perrais D, Tessier B, Giannone G, Thoumine O
Molecular biology of the cell (2015) 265: 859-73. 106 011
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Background

Synapsins are neuron-specific phosphoproteins that are exclusively associated with small synaptic vesicles, with little or no expression in other tissues including neuroendocrine cells. In mammals, three distinct synapsin genes (synapsin1, 2, and 3) encode more than eight neuronal isoforms.
Synapsin1 is one of the most specific markers of synapses throughout the central and peripheral nervous system. In addition to synaptic nerve terminals, the protein is also present in certain sensory nerve endings. It is expressed in two splice variants (synapsin 1a and synapsin 1b). Synapsin1 interacts with vesicle membranes as well as with actin and spectrin.
Synapsin2 is expressed in the nervous system and also two splice variants were described so far, while synapsin3 shows a more restricted expression pattern and is mainly found in the hypocampus.
Synapsins are major phosphoproteins and are substrates for several protein kinases such as PKA, CaMK I and CaMK II. Synapsin1 is widely used as reference substrate for calmodulin-dependent protein kinases.
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