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Home > Products > 106 002

Synapsin1/2 antibody - 106 002 K.O.

Synapsins are peripheral synaptic vesicle proteins and substrate for several protein kinases
Rabbit polyclonal antiserum
Cat. No.: 106 002
Amount: 200 µl
Price: $360.00
Cat. No. 106 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P: 1 : 500 gallery  
ExM: yes (see remarks) gallery  
ELISA: yes (see remarks)

Western blot (WB); separation of proteins by PAGE and subsequent transfer to a membrane. Detection of target molecules is carried out with antibodies. Some antibodies require special sample preparation steps. For details, please refer to the “Remarks” section.

Immunoprecipitation (IP); Immunoisolation or pulldown of a target molecule using an antibody. For details and product specific hints, please refer to the ”Remarks” section.

Immunocytochemistry (ICC) on 4% PFA fixed cells. Immunoreactivity is usually revealed by fluorescence. Some antibodies require special fixation methods. For details, please refer to the “Remarks” section.

Immunohistochemistry (IHC) on 4% PFA perfusion fixed tissue with 24h PFA post fixation. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Some antibodies require special fixation methods or antigen retrieval steps. For details, please refer to the ”Remarks” section.

Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate.

Expansion Microscopy (ExM) is a sample preparation and imaging method which employs a dense interconnected web of swellable polymer within a biological specimen. A significantly higher effective resolution can be achieved with a standard microscope setup. For additional experimental details, please refer to the Remarks section.

Enzyme-linked immunosorbent assay (ELISA); a frequently employed method to quantify target-molecules in solution. The detection of some proteins requires special solubilization steps. For further information, please refer to the „Remarks“ section.
Immunogen Synthetic peptide corresponding to AA 2 to 28 from rat Synapsin1 (UniProt Id: P09951)
Reactivity Reacts with: human (P17600, Q92777), rat (P09951, Q63537), mouse (O88935, Q64332), hamster, cow, zebrafish.
Other species not tested yet.
Specificity Specific for synapsins 1a/b and 2a/b. K.O. validated PubMed: 36742338
Matching control protein/peptide 106-0P
Remarks

ExM: This antibody has been successfully used for the epitope-preserving magnified analysis of the proteome (eMAP) expansion microscopy method (Park et al. 2021. PMID: 34767453).
ELISA: Suitable as detector antibody for sandwich-ELISA with cat. no. 106 011 as capture antibody. The ELISA-protocol for membrane proteins is recommended.
Data sheet 106_002.pdf

References for Synapsin1/2 - 106 002

Maternal synapsin autoantibodies are associated with neurodevelopmental delay.
Bünger I, Makridis KL, Kreye J, Nikolaus M, Sedlin E, Ullrich T, Hoffmann C, Tromm JV, Rasmussen HF, Milovanovic D, Höltje M, et al.
Frontiers in immunology (2023) 14: 1101087. 106 002 WB, ICC; KO verified; tested species: human,mouse
Synapsin autoantibodies during pregnancy are associated with fetal abnormalities.
Bünger I, Talucci I, Kreye J, Höltje M, Makridis KL, Foverskov Rasmussen H, van Hoof S, Cordero-Gomez C, Ullrich T, Sedlin E, Kreissner KO, et al.
Brain, behavior, & immunity - health (2023) 33: 100678. 106 002 WB, ICC; KO verified; tested species: human,mouse,rat
The proteomic landscape of synaptic diversity across brain regions and cell types.
van Oostrum M, Blok TM, Giandomenico SL, Tom Dieck S, Tushev G, Fürst N, Langer JD, Schuman EM
Cell (2023) 18624: 5411-5427.e23. 106 002 WB; tested species: mouse
A novel synaptopathy-defective synaptic vesicle protein trafficking in the mutant CHMP2B mouse model of frontotemporal dementia.
Clayton EL, Bonnycastle K, Isaacs AM, Cousin MA, Schorge S
Journal of neurochemistry (2022) 1603: 412-425. 106 002 WB; tested species: mouse
Inhibition of colony-stimulating factor 1 receptor early in disease ameliorates motor deficits in SCA1 mice.
Qu W, Johnson A, Kim JH, Lukowicz A, Svedberg D, Cvetanovic M
Journal of neuroinflammation (2017) 141: 107. 106 002 WB; tested species: mouse
Identification of β-Dystrobrevin as a Direct Target of miR-143: Involvement in Early Stages of Neural Differentiation.
Quaranta MT, Spinello I, Paolillo R, Macchia G, Boe A, Ceccarini M, Labbaye C, Macioce P
PloS one (2016) 115: e0156325. 106 002 WB; tested species: human
Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission.
Spangler SA, Schmitz SK, Kevenaar JT, de Graaff E, de Wit H, Demmers J, Toonen RF, Hoogenraad CC
The Journal of cell biology (2013) 2016: 915-28. 106 002 ICC, WB; tested species: rat
Long-lasting hippocampal synaptic protein loss in a mouse model of posttraumatic stress disorder.
Herrmann L, Ionescu IA, Henes K, Golub Y, Wang NX, Buell DR, Holsboer F, Wotjak CT, Schmidt U
PloS one (2012) 78: e42603. 106 002 WB, IHC; tested species: mouse
Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing.
Lazarevic V, Schöne C, Heine M, Gundelfinger ED, Fejtova A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3128: 10189-200. 106 002 WB, ICC
Identification of an endogenous substrate of zebrafish doublecortin-like protein kinase using a highly active truncation mutant.
Shimomura S, Nagamine T, Hatano N, Sueyoshi N, Kameshita I
Journal of biochemistry (2010) 1475: 711-22. 106 002 WB; tested species: zebrafish
SV2B regulates synaptotagmin 1 by direct interaction.
Lazzell DR, Belizaire R, Thakur P, Sherry DM, Janz R
The Journal of biological chemistry (2004) 27950: 52124-31. 106 002 WB; tested species: mouse
Synapsin autoantibodies during pregnancy are associated with fetal abnormalities.
Bünger I, Talucci I, Kreye J, Höltje M, Makridis KL, Foverskov Rasmussen H, van Hoof S, Cordero-Gomez C, Ullrich T, Sedlin E, Kreissner KO, et al.
Brain, behavior, & immunity - health (2023) 33: 100678. 106 002 WB, ICC; KO verified; tested species: human,mouse,rat
Maternal synapsin autoantibodies are associated with neurodevelopmental delay.
Bünger I, Makridis KL, Kreye J, Nikolaus M, Sedlin E, Ullrich T, Hoffmann C, Tromm JV, Rasmussen HF, Milovanovic D, Höltje M, et al.
Frontiers in immunology (2023) 14: 1101087. 106 002 WB, ICC; KO verified; tested species: human,mouse
Aβ1-16 controls synaptic vesicle pools at excitatory synapses via cholinergic modulation of synapsin phosphorylation.
Anni D, Weiss EM, Guhathakurta D, Akdas YE, Klueva J, Zeitler S, Andres-Alonso M, Huth T, Fejtova A
Cellular and molecular life sciences : CMLS (2021) : . 106 002 ICC; tested species: rat
An Autism-Associated Mutation Impairs Neuroligin-4 Glycosylation and Enhances Excitatory Synaptic Transmission in Human Neurons.
Cast T, Boesch D, Smyth K, Shaw A, Ghebrial M, Chanda S
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 106 002 ICC; tested species: human
Presynaptic α2δ-2 Calcium Channel Subunits Regulate Postsynaptic GABAA Receptor Abundance and Axonal Wiring.
Geisler S, Schöpf CL, Stanika R, Kalb M, Campiglio M, Repetto D, Traxler L, Missler M, Obermair GJ
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) 3914: 2581-2605. 106 002 ICC; tested species: mouse
Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons.
Marro SG, Chanda S, Yang N, Janas JA, Valperga G, Trotter J, Zhou B, Merrill S, Yousif I, Shelby H, Vogel H, et al.
Neuron (2019) 1034: 617-626.e6. 106 002 ICC; tested species: human
Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies.
Szegő ÉM, Dominguez-Meijide A, Gerhardt E, König A, Koss DJ, Li W, Pinho R, Fahlbusch C, Johnson M, Santos P, Villar-Piqué A, et al.
Cell reports (2019) 281: 65-77.e6. 106 002 ICC; tested species: rat
α-Actinin Anchors PSD-95 at Postsynaptic Sites.
Matt L, Kim K, Hergarden AC, Patriarchi T, Malik ZA, Park DK, Chowdhury D, Buonarati OR, Henderson PB, Gökçek Saraç Ç, Zhang Y, et al.
Neuron (2018) 975: 1094-1109.e9. 106 002 ICC; tested species: rat
Epitope specificity of anti-synapsin autoantibodies: Differential targeting of synapsin I domains.
Mertens R, Melchert S, Gitler D, Schou MB, Saether SG, Vaaler A, Piepgras J, Kochova E, Benfenati F, Ahnert-Hilger G, Ruprecht K, et al.
PloS one (2018) 1312: e0208636. 106 002 ICC; tested species: human
Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission.
Truckenbrodt S, Viplav A, Jähne S, Vogts A, Denker A, Wildhagen H, Fornasiero EF, Rizzoli SO
The EMBO journal (2018) : . 106 002 ICC; tested species: rat
SUMO1-conjugation is altered during normal aging but not by increased amyloid burden.
Stankova T, Piepkorn L, Bayer TA, Jahn O, Tirard M
Aging cell (2018) : e12760. 106 002 ICC; tested species: mouse
Caldendrin Directly Couples Postsynaptic Calcium Signals to Actin Remodeling in Dendritic Spines.
Mikhaylova M, Bär J, van Bommel B, Schätzle P, YuanXiang P, Raman R, Hradsky J, Konietzny A, Loktionov EY, Reddy PP, Lopez-Rojas J, et al.
Neuron (2018) 975: 1110-1125.e14. 106 002 ICC; tested species: mouse
The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons.
Moruno-Manchon JF, Koellhoffer EC, Gopakumar J, Hambarde S, Kim N, McCullough LD, Tsvetkov AS
Aging (2017) 99: 1957-1970. 106 002 ICC; tested species: rat
Analysis of SUMO1-conjugation at synapses.
Daniel JA, Cooper BH, Palvimo JJ, Zhang FP, Brose N, Tirard M
eLife (2017) 6: . 106 002 ICC; tested species: mouse
Astrocyte VAMP3 vesicles undergo Ca2+ -independent cycling and modulate glutamate transporter trafficking.
Li D, Hérault K, Zylbersztejn K, Lauterbach MA, Guillon M, Oheim M, Ropert N
The Journal of physiology (2015) 59313: 2807-32. 106 002 ICC
Munc18-1 redistributes in nerve terminals in an activity- and PKC-dependent manner.
Cijsouw T, Weber JP, Broeke JH, Broek JA, Schut D, Kroon T, Saarloos I, Verhage M, Toonen RF
The Journal of cell biology (2014) 2045: 759-75. 106 002 ICC; tested species: mouse
Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density.
Ferron L, Nieto-Rostro M, Cassidy JS, Dolphin AC
Nature communications (2014) 5: 3628. 106 002 ICC
A new probe for super-resolution imaging of membranes elucidates trafficking pathways.
Revelo NH, Kamin D, Truckenbrodt S, Wong AB, Reuter-Jessen K, Reisinger E, Moser T, Rizzoli SO
The Journal of cell biology (2014) 2054: 591-606. 106 002 ICC
Novel cell types, neurosecretory cells, and body plan of the early-diverging metazoan Trichoplax adhaerens.
Smith CL, Varoqueaux F, Kittelmann M, Azzam RN, Cooper B, Winters CA, Eitel M, Fasshauer D, Reese TS
Current biology : CB (2014) 2414: 1565-1572. 106 002 ICC
Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission.
Spangler SA, Schmitz SK, Kevenaar JT, de Graaff E, de Wit H, Demmers J, Toonen RF, Hoogenraad CC
The Journal of cell biology (2013) 2016: 915-28. 106 002 ICC, WB; tested species: rat
Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes.
Jovičić A, Roshan R, Moisoi N, Pradervand S, Moser R, Pillai B, Luthi-Carter R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3312: 5127-37. 106 002 ICC; tested species: rat
Differential control of thrombospondin over synaptic glycine and AMPA receptors in spinal cord neurons.
Hennekinne L, Colasse S, Triller A, Renner M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3328: 11432-9. 106 002 ICC; tested species: rat
Phenotype and Stability of Neural Differentiation of Androgenetic Murine ES Cell-Derived Neural Progenitor Cells.
Wolber W, Ahmad R, Choi SW, Eckardt S, McLaughlin KJ, Schmitt J, Geis C, Heckmann M, Sirén AL, Müller AM
Cell medicine (2013) 51: 29-42. 106 002 ICC; tested species: mouse
Lateral mobility of presynaptic α7-containing nicotinic receptors and its relevance for glutamate release.
Gomez-Varela D, Berg DK
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3343: 17062-71. 106 002 ICC; tested species: rat
Effects of erythropoietin in murine-induced pluripotent cell-derived panneural progenitor cells.
Offen N, Flemming J, Kamawal H, Ahmad R, Wolber W, Geis C, Zaehres H, Schöler HR, Ehrenreich H, Müller AM, Sirén AL, et al.
Molecular medicine (Cambridge, Mass.) (2013) 19: 399-408. 106 002 ICC; tested species: mouse
Neuronal profilin isoforms are addressed by different signalling pathways.
Murk K, Wittenmayer N, Michaelsen-Preusse K, Dresbach T, Schoenenberger CA, Korte M, Jockusch BM, Rothkegel M
PloS one (2012) 73: e34167. 106 002 ICC; tested species: mouse,rat
Hindered submicron mobility and long-term storage of presynaptic dense-core granules revealed by single-particle tracking.
Scalettar BA, Jacobs C, Fulwiler A, Prahl L, Simon A, Hilken L, Lochner JE
Developmental neurobiology (2012) 729: 1181-95. 106 002 ICC
N-methyl-D-aspartate receptor antibodies in herpes simplex encephalitis.
Prüss H, Finke C, Höltje M, Hofmann J, Klingbeil C, Probst C, Borowski K, Ahnert-Hilger G, Harms L, Schwab JM, Ploner CJ, et al.
Annals of neurology (2012) 726: 902-11. 106 002 ICC
Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing.
Lazarevic V, Schöne C, Heine M, Gundelfinger ED, Fejtova A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3128: 10189-200. 106 002 WB, ICC
In vivo imaging of intersynaptic vesicle exchange using VGLUT1 Venus knock-in mice.
Herzog E, Nadrigny F, Silm K, Biesemann C, Helling I, Bersot T, Steffens H, Schwartzmann R, Nägerl UV, El Mestikawy S, Rhee J, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3143: 15544-59. 106 002 ICC; tested species: mouse
Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development.
Kawabe H, Neeb A, Dimova K, Young SM, Takeda M, Katsurabayashi S, Mitkovski M, Malakhova OA, Zhang DE, Umikawa M, Kariya K, et al.
Neuron (2010) 653: 358-72. 106 002 ICC; tested species: mouse
SynCAMs organize synapses through heterophilic adhesion.
Fogel AI, Akins MR, Krupp AJ, Stagi M, Stein V, Biederer T
The Journal of neuroscience : the official journal of the Society for Neuroscience (2007) 2746: 12516-30. 106 002 ICC
Immunolocalization of BK channels in hippocampal pyramidal neurons.
Sailer CA, Kaufmann WA, Kogler M, Chen L, Sausbier U, Ottersen OP, Ruth P, Shipston MJ, Knaus HG
The European journal of neuroscience (2006) 242: 442-54. 106 002 ICC; tested species: mouse
ARGX-119 is an agonist antibody for human MuSK that reverses disease relapse in a mouse model of congenital myasthenic syndrome.
Vanhauwaert R, Oury J, Vankerckhoven B, Steyaert C, Jensen SM, Vergoossen DLE, Kneip C, Santana L, Lim JL, Plomp JJ, Augustinus R, et al.
Science translational medicine (2024) 16765: eado7189. 106 002 IHC; tested species: mouse
A zebrafish gephyrinb mutant distinguishes synaptic and enzymatic functions of Gephyrin.
Brennan EJ, Monk KR, Li J
Neural development (2024) 191: 14. 106 002 IHC; tested species: zebrafish
Synaptic input and Ca2+ activity in zebrafish oligodendrocyte precursor cells contribute to myelin sheath formation.
Li J, Miramontes TG, Czopka T, Monk KR
Nature neuroscience (2024) 272: 219-231. 106 002 IHC; tested species: zebrafish
Genoarchitectonics of the larval zebrafish diencephalon.
Wullimann MF, Mokayes N, Shainer I, Kuehn E, Baier H
The Journal of comparative neurology (2024) 5323: e25549. 106 002 IHC; tested species: zebrafish
The functional maturity of grafted human pluripotent stem cell derived-islets (hSC-Islets) evaluated by the glycemic set point during blood glucose normalizing process in diabetic mice.
Yabe SG, Fukuda S, Nishida J, Takeda F, Okochi H
Heliyon (2023) 99: e19972. 106 002 IHC; tested species: mouse
Egr1 Is Necessary for Forebrain Dopaminergic Signaling during Social Behavior.
Tallafuss A, Stednitz SJ, Voeun M, Levichev A, Larsch J, Eisen J, Washbourne P
eNeuro (2022) 92: . 106 002 IHC; tested species: zebrafish
Counteractive and cooperative actions of muscle β-catenin and CaV1.1 during early neuromuscular synapse formation.
Kaplan MM, Flucher BE
iScience (2022) 254: 104025. 106 002 IHC; tested species: mouse
Mechanism of disease and therapeutic rescue of Dok7 congenital myasthenia.
Oury J, Zhang W, Leloup N, Koide A, Corrado AD, Ketavarapu G, Hattori T, Koide S, Burden SJ
Nature (2021) : . 106 002 IHC; tested species: mouse
AP180 promotes release site clearance and clathrin-dependent vesicle reformation in mouse cochlear inner hair cells.
Kroll J, Özçete ÖD, Jung S, Maritzen T, Milosevic I, Wichmann C, Moser T
Journal of cell science (2020) 1332: . 106 002 IHC; tested species: mouse
Late onset of Synaptotagmin 2a expression at synapses relevant to social behavior.
Goode C, Voeun M, Ncube D, Eisen J, Washbourne P, Tallafuss A
The Journal of comparative neurology (2020) : . 106 002 IHC; tested species: zebrafish
Neuronal brain-derived neurotrophic factor manipulates microglial dynamics.
Onodera J, Nagata H, Nakashima A, Ikegaya Y, Koyama R
Glia (2020) : . 106 002 IHC; tested species: mouse
Vezatin is Required for the Maturation of the Neuromuscular Synapse.
Koppel N, Friese MB, Cardasis HL, Neubert TA, Burden SJ
Molecular biology of the cell (2019) : mbcE19060313. 106 002 IHC; tested species: mouse
Synaptic-like Vesicles Facilitate Pioneer Axon Invasion.
Nichols EL, Smith CJ
Current biology : CB (2019) : . 106 002 IHC; tested species: zebrafish
Analysis of Synapses in Cerebral Organoids.
Yakoub AM, Sadek M
Cell transplantation (2019) : 963689718822811. 106 002 IHC; tested species: human
MACF1 links Rapsyn to microtubule- and actin-binding proteins to maintain neuromuscular synapses.
Oury J, Liu Y, Töpf A, Todorovic S, Hoedt E, Preethish-Kumar V, Neubert TA, Lin W, Lochmüller H, Burden SJ
The Journal of cell biology (2019) : . 106 002 IHC; tested species: mouse
Transgenic FingRs for Live Mapping of Synaptic Dynamics in Genetically-Defined Neurons.
Son JH, Keefe MD, Stevenson TJ, Barrios JP, Anjewierden S, Newton JB, Douglass AD, Bonkowsky JL
Scientific reports (2016) 6: 18734. 106 002 IHC
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 106 002 IHC; tested species: mouse
Late recruitment of synapsin to nascent synapses is regulated by Cdk5.
Easley-Neal C, Fierro J, Buchanan J, Washbourne P
Cell reports (2013) 34: 1199-212. 106 002 IHC; tested species: zebrafish
Neonatal leptin exposure specifies innervation of presympathetic hypothalamic neurons and improves the metabolic status of leptin-deficient mice.
Bouyer K, Simerly RB
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 332: 840-51. 106 002 IHC; tested species: mouse
Lack of evidence for vesicular glutamate transporter expression in mouse astrocytes.
Li D, Hérault K, Silm K, Evrard A, Wojcik S, Oheim M, Herzog E, Ropert N
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3310: 4434-55. 106 002 IHC; tested species: mouse
Metabolic Maturation of Auditory Neurones in the Superior Olivary Complex.
Trattner B, Gravot CM, Grothe B, Kunz L
PloS one (2013) 86: e67351. 106 002 IHC; tested species: mouse
Long-lasting hippocampal synaptic protein loss in a mouse model of posttraumatic stress disorder.
Herrmann L, Ionescu IA, Henes K, Golub Y, Wang NX, Buell DR, Holsboer F, Wotjak CT, Schmidt U
PloS one (2012) 78: e42603. 106 002 WB, IHC; tested species: mouse
Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse.
Varoqueaux F, Sons MS, Plomp JJ, Brose N
Molecular and cellular biology (2005) 2514: 5973-84. 106 002 IHC
Changes in retinal synaptic proteins in the transgenic model expressing a mutant HRG4 (UNC119).
Kubota S, Kobayashi A, Mori N, Higashide T, McLaren MJ, Inana G
Investigative ophthalmology & visual science (2002) 432: 308-13. 106 002 IHC
Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission.
Vasileva M, Horstmann H, Geumann C, Gitler D, Kuner T
The European journal of neuroscience (2012) 368: 3005-20. 106 002 ELISA
Cat. No.: 106 002
Amount: 200 µl
Price: $360.00
Maternal synapsin autoantibodies are associated with neurodevelopmental delay.
Bünger I, Makridis KL, Kreye J, Nikolaus M, Sedlin E, Ullrich T, Hoffmann C, Tromm JV, Rasmussen HF, Milovanovic D, Höltje M, et al.
Frontiers in immunology (2023) 14: 1101087. 106 002 WB, ICC; KO verified; tested species: human,mouse
Synapsin autoantibodies during pregnancy are associated with fetal abnormalities.
Bünger I, Talucci I, Kreye J, Höltje M, Makridis KL, Foverskov Rasmussen H, van Hoof S, Cordero-Gomez C, Ullrich T, Sedlin E, Kreissner KO, et al.
Brain, behavior, & immunity - health (2023) 33: 100678. 106 002 WB, ICC; KO verified; tested species: human,mouse,rat
The proteomic landscape of synaptic diversity across brain regions and cell types.
van Oostrum M, Blok TM, Giandomenico SL, Tom Dieck S, Tushev G, Fürst N, Langer JD, Schuman EM
Cell (2023) 18624: 5411-5427.e23. 106 002 WB; tested species: mouse
A novel synaptopathy-defective synaptic vesicle protein trafficking in the mutant CHMP2B mouse model of frontotemporal dementia.
Clayton EL, Bonnycastle K, Isaacs AM, Cousin MA, Schorge S
Journal of neurochemistry (2022) 1603: 412-425. 106 002 WB; tested species: mouse
Inhibition of colony-stimulating factor 1 receptor early in disease ameliorates motor deficits in SCA1 mice.
Qu W, Johnson A, Kim JH, Lukowicz A, Svedberg D, Cvetanovic M
Journal of neuroinflammation (2017) 141: 107. 106 002 WB; tested species: mouse
Identification of β-Dystrobrevin as a Direct Target of miR-143: Involvement in Early Stages of Neural Differentiation.
Quaranta MT, Spinello I, Paolillo R, Macchia G, Boe A, Ceccarini M, Labbaye C, Macioce P
PloS one (2016) 115: e0156325. 106 002 WB; tested species: human
Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission.
Spangler SA, Schmitz SK, Kevenaar JT, de Graaff E, de Wit H, Demmers J, Toonen RF, Hoogenraad CC
The Journal of cell biology (2013) 2016: 915-28. 106 002 ICC, WB; tested species: rat
Long-lasting hippocampal synaptic protein loss in a mouse model of posttraumatic stress disorder.
Herrmann L, Ionescu IA, Henes K, Golub Y, Wang NX, Buell DR, Holsboer F, Wotjak CT, Schmidt U
PloS one (2012) 78: e42603. 106 002 WB, IHC; tested species: mouse
Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing.
Lazarevic V, Schöne C, Heine M, Gundelfinger ED, Fejtova A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3128: 10189-200. 106 002 WB, ICC
Identification of an endogenous substrate of zebrafish doublecortin-like protein kinase using a highly active truncation mutant.
Shimomura S, Nagamine T, Hatano N, Sueyoshi N, Kameshita I
Journal of biochemistry (2010) 1475: 711-22. 106 002 WB; tested species: zebrafish
SV2B regulates synaptotagmin 1 by direct interaction.
Lazzell DR, Belizaire R, Thakur P, Sherry DM, Janz R
The Journal of biological chemistry (2004) 27950: 52124-31. 106 002 WB; tested species: mouse
Synapsin autoantibodies during pregnancy are associated with fetal abnormalities.
Bünger I, Talucci I, Kreye J, Höltje M, Makridis KL, Foverskov Rasmussen H, van Hoof S, Cordero-Gomez C, Ullrich T, Sedlin E, Kreissner KO, et al.
Brain, behavior, & immunity - health (2023) 33: 100678. 106 002 WB, ICC; KO verified; tested species: human,mouse,rat
Maternal synapsin autoantibodies are associated with neurodevelopmental delay.
Bünger I, Makridis KL, Kreye J, Nikolaus M, Sedlin E, Ullrich T, Hoffmann C, Tromm JV, Rasmussen HF, Milovanovic D, Höltje M, et al.
Frontiers in immunology (2023) 14: 1101087. 106 002 WB, ICC; KO verified; tested species: human,mouse
Aβ1-16 controls synaptic vesicle pools at excitatory synapses via cholinergic modulation of synapsin phosphorylation.
Anni D, Weiss EM, Guhathakurta D, Akdas YE, Klueva J, Zeitler S, Andres-Alonso M, Huth T, Fejtova A
Cellular and molecular life sciences : CMLS (2021) : . 106 002 ICC; tested species: rat
An Autism-Associated Mutation Impairs Neuroligin-4 Glycosylation and Enhances Excitatory Synaptic Transmission in Human Neurons.
Cast T, Boesch D, Smyth K, Shaw A, Ghebrial M, Chanda S
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 106 002 ICC; tested species: human
Presynaptic α2δ-2 Calcium Channel Subunits Regulate Postsynaptic GABAA Receptor Abundance and Axonal Wiring.
Geisler S, Schöpf CL, Stanika R, Kalb M, Campiglio M, Repetto D, Traxler L, Missler M, Obermair GJ
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) 3914: 2581-2605. 106 002 ICC; tested species: mouse
Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons.
Marro SG, Chanda S, Yang N, Janas JA, Valperga G, Trotter J, Zhou B, Merrill S, Yousif I, Shelby H, Vogel H, et al.
Neuron (2019) 1034: 617-626.e6. 106 002 ICC; tested species: human
Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies.
Szegő ÉM, Dominguez-Meijide A, Gerhardt E, König A, Koss DJ, Li W, Pinho R, Fahlbusch C, Johnson M, Santos P, Villar-Piqué A, et al.
Cell reports (2019) 281: 65-77.e6. 106 002 ICC; tested species: rat
α-Actinin Anchors PSD-95 at Postsynaptic Sites.
Matt L, Kim K, Hergarden AC, Patriarchi T, Malik ZA, Park DK, Chowdhury D, Buonarati OR, Henderson PB, Gökçek Saraç Ç, Zhang Y, et al.
Neuron (2018) 975: 1094-1109.e9. 106 002 ICC; tested species: rat
Epitope specificity of anti-synapsin autoantibodies: Differential targeting of synapsin I domains.
Mertens R, Melchert S, Gitler D, Schou MB, Saether SG, Vaaler A, Piepgras J, Kochova E, Benfenati F, Ahnert-Hilger G, Ruprecht K, et al.
PloS one (2018) 1312: e0208636. 106 002 ICC; tested species: human
Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission.
Truckenbrodt S, Viplav A, Jähne S, Vogts A, Denker A, Wildhagen H, Fornasiero EF, Rizzoli SO
The EMBO journal (2018) : . 106 002 ICC; tested species: rat
SUMO1-conjugation is altered during normal aging but not by increased amyloid burden.
Stankova T, Piepkorn L, Bayer TA, Jahn O, Tirard M
Aging cell (2018) : e12760. 106 002 ICC; tested species: mouse
Caldendrin Directly Couples Postsynaptic Calcium Signals to Actin Remodeling in Dendritic Spines.
Mikhaylova M, Bär J, van Bommel B, Schätzle P, YuanXiang P, Raman R, Hradsky J, Konietzny A, Loktionov EY, Reddy PP, Lopez-Rojas J, et al.
Neuron (2018) 975: 1110-1125.e14. 106 002 ICC; tested species: mouse
The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons.
Moruno-Manchon JF, Koellhoffer EC, Gopakumar J, Hambarde S, Kim N, McCullough LD, Tsvetkov AS
Aging (2017) 99: 1957-1970. 106 002 ICC; tested species: rat
Analysis of SUMO1-conjugation at synapses.
Daniel JA, Cooper BH, Palvimo JJ, Zhang FP, Brose N, Tirard M
eLife (2017) 6: . 106 002 ICC; tested species: mouse
Astrocyte VAMP3 vesicles undergo Ca2+ -independent cycling and modulate glutamate transporter trafficking.
Li D, Hérault K, Zylbersztejn K, Lauterbach MA, Guillon M, Oheim M, Ropert N
The Journal of physiology (2015) 59313: 2807-32. 106 002 ICC
Munc18-1 redistributes in nerve terminals in an activity- and PKC-dependent manner.
Cijsouw T, Weber JP, Broeke JH, Broek JA, Schut D, Kroon T, Saarloos I, Verhage M, Toonen RF
The Journal of cell biology (2014) 2045: 759-75. 106 002 ICC; tested species: mouse
Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density.
Ferron L, Nieto-Rostro M, Cassidy JS, Dolphin AC
Nature communications (2014) 5: 3628. 106 002 ICC
A new probe for super-resolution imaging of membranes elucidates trafficking pathways.
Revelo NH, Kamin D, Truckenbrodt S, Wong AB, Reuter-Jessen K, Reisinger E, Moser T, Rizzoli SO
The Journal of cell biology (2014) 2054: 591-606. 106 002 ICC
Novel cell types, neurosecretory cells, and body plan of the early-diverging metazoan Trichoplax adhaerens.
Smith CL, Varoqueaux F, Kittelmann M, Azzam RN, Cooper B, Winters CA, Eitel M, Fasshauer D, Reese TS
Current biology : CB (2014) 2414: 1565-1572. 106 002 ICC
Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission.
Spangler SA, Schmitz SK, Kevenaar JT, de Graaff E, de Wit H, Demmers J, Toonen RF, Hoogenraad CC
The Journal of cell biology (2013) 2016: 915-28. 106 002 ICC, WB; tested species: rat
Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes.
Jovičić A, Roshan R, Moisoi N, Pradervand S, Moser R, Pillai B, Luthi-Carter R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3312: 5127-37. 106 002 ICC; tested species: rat
Differential control of thrombospondin over synaptic glycine and AMPA receptors in spinal cord neurons.
Hennekinne L, Colasse S, Triller A, Renner M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3328: 11432-9. 106 002 ICC; tested species: rat
Phenotype and Stability of Neural Differentiation of Androgenetic Murine ES Cell-Derived Neural Progenitor Cells.
Wolber W, Ahmad R, Choi SW, Eckardt S, McLaughlin KJ, Schmitt J, Geis C, Heckmann M, Sirén AL, Müller AM
Cell medicine (2013) 51: 29-42. 106 002 ICC; tested species: mouse
Lateral mobility of presynaptic α7-containing nicotinic receptors and its relevance for glutamate release.
Gomez-Varela D, Berg DK
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3343: 17062-71. 106 002 ICC; tested species: rat
Effects of erythropoietin in murine-induced pluripotent cell-derived panneural progenitor cells.
Offen N, Flemming J, Kamawal H, Ahmad R, Wolber W, Geis C, Zaehres H, Schöler HR, Ehrenreich H, Müller AM, Sirén AL, et al.
Molecular medicine (Cambridge, Mass.) (2013) 19: 399-408. 106 002 ICC; tested species: mouse
Neuronal profilin isoforms are addressed by different signalling pathways.
Murk K, Wittenmayer N, Michaelsen-Preusse K, Dresbach T, Schoenenberger CA, Korte M, Jockusch BM, Rothkegel M
PloS one (2012) 73: e34167. 106 002 ICC; tested species: mouse,rat
Hindered submicron mobility and long-term storage of presynaptic dense-core granules revealed by single-particle tracking.
Scalettar BA, Jacobs C, Fulwiler A, Prahl L, Simon A, Hilken L, Lochner JE
Developmental neurobiology (2012) 729: 1181-95. 106 002 ICC
N-methyl-D-aspartate receptor antibodies in herpes simplex encephalitis.
Prüss H, Finke C, Höltje M, Hofmann J, Klingbeil C, Probst C, Borowski K, Ahnert-Hilger G, Harms L, Schwab JM, Ploner CJ, et al.
Annals of neurology (2012) 726: 902-11. 106 002 ICC
Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing.
Lazarevic V, Schöne C, Heine M, Gundelfinger ED, Fejtova A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3128: 10189-200. 106 002 WB, ICC
In vivo imaging of intersynaptic vesicle exchange using VGLUT1 Venus knock-in mice.
Herzog E, Nadrigny F, Silm K, Biesemann C, Helling I, Bersot T, Steffens H, Schwartzmann R, Nägerl UV, El Mestikawy S, Rhee J, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3143: 15544-59. 106 002 ICC; tested species: mouse
Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development.
Kawabe H, Neeb A, Dimova K, Young SM, Takeda M, Katsurabayashi S, Mitkovski M, Malakhova OA, Zhang DE, Umikawa M, Kariya K, et al.
Neuron (2010) 653: 358-72. 106 002 ICC; tested species: mouse
SynCAMs organize synapses through heterophilic adhesion.
Fogel AI, Akins MR, Krupp AJ, Stagi M, Stein V, Biederer T
The Journal of neuroscience : the official journal of the Society for Neuroscience (2007) 2746: 12516-30. 106 002 ICC
Immunolocalization of BK channels in hippocampal pyramidal neurons.
Sailer CA, Kaufmann WA, Kogler M, Chen L, Sausbier U, Ottersen OP, Ruth P, Shipston MJ, Knaus HG
The European journal of neuroscience (2006) 242: 442-54. 106 002 ICC; tested species: mouse
ARGX-119 is an agonist antibody for human MuSK that reverses disease relapse in a mouse model of congenital myasthenic syndrome.
Vanhauwaert R, Oury J, Vankerckhoven B, Steyaert C, Jensen SM, Vergoossen DLE, Kneip C, Santana L, Lim JL, Plomp JJ, Augustinus R, et al.
Science translational medicine (2024) 16765: eado7189. 106 002 IHC; tested species: mouse
A zebrafish gephyrinb mutant distinguishes synaptic and enzymatic functions of Gephyrin.
Brennan EJ, Monk KR, Li J
Neural development (2024) 191: 14. 106 002 IHC; tested species: zebrafish
Synaptic input and Ca2+ activity in zebrafish oligodendrocyte precursor cells contribute to myelin sheath formation.
Li J, Miramontes TG, Czopka T, Monk KR
Nature neuroscience (2024) 272: 219-231. 106 002 IHC; tested species: zebrafish
Genoarchitectonics of the larval zebrafish diencephalon.
Wullimann MF, Mokayes N, Shainer I, Kuehn E, Baier H
The Journal of comparative neurology (2024) 5323: e25549. 106 002 IHC; tested species: zebrafish
The functional maturity of grafted human pluripotent stem cell derived-islets (hSC-Islets) evaluated by the glycemic set point during blood glucose normalizing process in diabetic mice.
Yabe SG, Fukuda S, Nishida J, Takeda F, Okochi H
Heliyon (2023) 99: e19972. 106 002 IHC; tested species: mouse
Egr1 Is Necessary for Forebrain Dopaminergic Signaling during Social Behavior.
Tallafuss A, Stednitz SJ, Voeun M, Levichev A, Larsch J, Eisen J, Washbourne P
eNeuro (2022) 92: . 106 002 IHC; tested species: zebrafish
Counteractive and cooperative actions of muscle β-catenin and CaV1.1 during early neuromuscular synapse formation.
Kaplan MM, Flucher BE
iScience (2022) 254: 104025. 106 002 IHC; tested species: mouse
Mechanism of disease and therapeutic rescue of Dok7 congenital myasthenia.
Oury J, Zhang W, Leloup N, Koide A, Corrado AD, Ketavarapu G, Hattori T, Koide S, Burden SJ
Nature (2021) : . 106 002 IHC; tested species: mouse
AP180 promotes release site clearance and clathrin-dependent vesicle reformation in mouse cochlear inner hair cells.
Kroll J, Özçete ÖD, Jung S, Maritzen T, Milosevic I, Wichmann C, Moser T
Journal of cell science (2020) 1332: . 106 002 IHC; tested species: mouse
Late onset of Synaptotagmin 2a expression at synapses relevant to social behavior.
Goode C, Voeun M, Ncube D, Eisen J, Washbourne P, Tallafuss A
The Journal of comparative neurology (2020) : . 106 002 IHC; tested species: zebrafish
Neuronal brain-derived neurotrophic factor manipulates microglial dynamics.
Onodera J, Nagata H, Nakashima A, Ikegaya Y, Koyama R
Glia (2020) : . 106 002 IHC; tested species: mouse
Vezatin is Required for the Maturation of the Neuromuscular Synapse.
Koppel N, Friese MB, Cardasis HL, Neubert TA, Burden SJ
Molecular biology of the cell (2019) : mbcE19060313. 106 002 IHC; tested species: mouse
Synaptic-like Vesicles Facilitate Pioneer Axon Invasion.
Nichols EL, Smith CJ
Current biology : CB (2019) : . 106 002 IHC; tested species: zebrafish
Analysis of Synapses in Cerebral Organoids.
Yakoub AM, Sadek M
Cell transplantation (2019) : 963689718822811. 106 002 IHC; tested species: human
MACF1 links Rapsyn to microtubule- and actin-binding proteins to maintain neuromuscular synapses.
Oury J, Liu Y, Töpf A, Todorovic S, Hoedt E, Preethish-Kumar V, Neubert TA, Lin W, Lochmüller H, Burden SJ
The Journal of cell biology (2019) : . 106 002 IHC; tested species: mouse
Transgenic FingRs for Live Mapping of Synaptic Dynamics in Genetically-Defined Neurons.
Son JH, Keefe MD, Stevenson TJ, Barrios JP, Anjewierden S, Newton JB, Douglass AD, Bonkowsky JL
Scientific reports (2016) 6: 18734. 106 002 IHC
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 106 002 IHC; tested species: mouse
Late recruitment of synapsin to nascent synapses is regulated by Cdk5.
Easley-Neal C, Fierro J, Buchanan J, Washbourne P
Cell reports (2013) 34: 1199-212. 106 002 IHC; tested species: zebrafish
Neonatal leptin exposure specifies innervation of presympathetic hypothalamic neurons and improves the metabolic status of leptin-deficient mice.
Bouyer K, Simerly RB
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 332: 840-51. 106 002 IHC; tested species: mouse
Lack of evidence for vesicular glutamate transporter expression in mouse astrocytes.
Li D, Hérault K, Silm K, Evrard A, Wojcik S, Oheim M, Herzog E, Ropert N
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3310: 4434-55. 106 002 IHC; tested species: mouse
Metabolic Maturation of Auditory Neurones in the Superior Olivary Complex.
Trattner B, Gravot CM, Grothe B, Kunz L
PloS one (2013) 86: e67351. 106 002 IHC; tested species: mouse
Long-lasting hippocampal synaptic protein loss in a mouse model of posttraumatic stress disorder.
Herrmann L, Ionescu IA, Henes K, Golub Y, Wang NX, Buell DR, Holsboer F, Wotjak CT, Schmidt U
PloS one (2012) 78: e42603. 106 002 WB, IHC; tested species: mouse
Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse.
Varoqueaux F, Sons MS, Plomp JJ, Brose N
Molecular and cellular biology (2005) 2514: 5973-84. 106 002 IHC
Changes in retinal synaptic proteins in the transgenic model expressing a mutant HRG4 (UNC119).
Kubota S, Kobayashi A, Mori N, Higashide T, McLaren MJ, Inana G
Investigative ophthalmology & visual science (2002) 432: 308-13. 106 002 IHC
Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission.
Vasileva M, Horstmann H, Geumann C, Gitler D, Kuner T
The European journal of neuroscience (2012) 368: 3005-20. 106 002 ELISA
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Background

Synapsins are neuron-specific phosphoproteins that are exclusively associated with small synaptic vesicles, with little or no expression in other tissues including neuroendocrine cells. In mammals, three distinct synapsin genes (synapsin 1, 2, and 3) encode more than eight neuronal isoforms.
Synapsin 1 is one of the most specific markers of synapses throughout the central and peripheral nervous system. In addition to synaptic nerve terminals, the protein is also present in certain sensory nerve endings. It is expressed in two splice variants (synapsin 1a and synapsin 1b). Synapsin 1 interacts with vesicle membranes as well as with actin and spectrin.
Synapsin 2 is expressed in the nervous system and also two splice variants were described so far, while synapsin 3 shows a more restricted expression pattern and is mainly found in the hypocampus.
Synapsins are major phosphoproteins and are substrates for several protein kinases such as PKA, CaMK I and CaMK II. Synapsin 1 is widely used as reference substrate for calmodulin-dependent protein kinases.
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