Endoplasmic reticulum stress impedes regulated secretion by governing key exocytotic and granulogenic molecular switches.Mukherjee M, Mukherjee C, Ghosh V, Jain A, Sadhukhan S, Dagar S, Sahu BS
Journal of cell science (2024) 1376: .
105 011 WB; tested species: rat
STON2 variations are involved in synaptic dysfunction and schizophrenia-like behaviors by regulating Syt1 trafficking.Ma Y, Gao K, Sun X, Wang J, Yang Y, Wu J, Chai A, Yao L, Liu N, Yu H, Su Y, et al.
Science bulletin (2024) : .
105 011 WB; tested species: human,mouse
Proximity labelling reveals effects of disease-causing mutation on the DNAJC5/cysteine string protein α interactome.Barker E, Milburn A, Helassa N, Hammond D, Sanchez-Soriano N, Morgan A, Barclay J
The Biochemical journal (2024) : .
105 011 WB; tested species: rat
Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis.Tan JZA, Jang SE, Batallas-Borja A, Bhembre N, Chandra M, Zhang L, Guo H, Ringuet MT, Widagdo J, Collins BM, Anggono V, et al.
Cell reports (2023) 4212: 113460.
105 011 WB, ICC; tested species: rat
Neurotransmitter release progressively desynchronizes in induced human neurons during synapse maturation and aging.Uzay B, Houcek A, Ma ZZ, Konradi C, Monteggia LM, Kavalali ET
Cell reports (2023) 422: 112042.
105 011 WB; tested species: human
Glutamatergic synapses from the insular cortex to the basolateral amygdala encode observational pain.Zhang MM, Geng AQ, Chen K, Wang J, Wang P, Qiu XT, Gu JX, Fan HW, Zhu DY, Yang SM, Chen QY, et al.
Neuron (2022) 11012: 1993-2008.e6.
105 011 WB; tested species: mouse
Analysis of tripartite Synaptotagmin-1-SNARE-complexin-1 complexes in solution.Jaczynska K, Esquivies L, Pfuetzner RA, Alten B, Brewer KD, Zhou Q, Kavalali ET, Brunger AT, Rizo J
FEBS open bio (2022) : .
105 011 WB, ICC; KD verified; tested species: rat
Defective lipid signalling caused by mutations in PIK3C2B underlies focal epilepsy.Gozzelino L, Kochlamazashvili G, Baldassari S, Mackintosh AI, Licchetta L, Iovino E, Liu YC, Bennett CA, Bennett MF, Damiano JA, Zsurka G, et al.
Brain : a journal of neurology (2022) 1457: 2313-2331.
105 011 WB; tested species: mouse
Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission.Liu GT, Kochlamazashvili G, Puchkov D, Müller R, Schultz C, Mackintosh AI, Vollweiter D, Haucke V, Soykan T
The EMBO journal (2022) : e109352.
105 011 WB; tested species: rat
Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses.López-Hernández T, Takenaka KI, Mori Y, Kongpracha P, Nagamori S, Haucke V, Takamori S
eLife (2022) 11: .
105 011 WB, ICC; tested species: mouse
Presynaptic mechanisms underlying GABAB-receptor-mediated inhibition of spontaneous neurotransmitter release.Alten B, Guzikowski NJ, Zurawski Z, Hamm HE, Kavalali ET
Cell reports (2022) 383: 110255.
105 011 WB; KD verified; tested species: rat
Human-Relevant Sensitivity of iPSC-Derived Human Motor Neurons to BoNT/A1 and B1.Schenke M, Prause HC, Bergforth W, Przykopanski A, Rummel A, Klawonn F, Seeger B
Toxins (2021) 138: .
105 011 WB; tested species: human
An optogenetic method for investigating presynaptic molecular regulation.Kay Y, Herring BE
Scientific reports (2021) 111: 11329.
105 011 WB; KD verified; tested species: human
Creatine transporter deficiency impairs stress-adaptation and brain energetics homeostasis.Chen HR, Zhang-Brotzge X, Morozov YM, Li Y, Wang S, Zhang H, Kuan IS, Fugate EM, Mao H, Sun YY, Rakic P, et al.
JCI insight (2021) : .
105 011 WB, IHC; tested species: mouse
Inhibitory control in neuronal networks relies on the extracellular matrix integrity.Dzyubenko E, Fleischer M, Manrique-Castano D, Borbor M, Kleinschnitz C, Faissner A, Hermann DM
Cellular and molecular life sciences : CMLS (2021) 7814: 5647-5663.
105 011 WB; tested species: mouse
Synapsin Condensates Recruit alpha-Synuclein.Hoffmann C, Sansevrino R, Morabito G, Logan C, Vabulas RM, Ulusoy A, Ganzella M, Milovanovic D
Journal of molecular biology (2021) 43312: 166961.
105 011 WB; tested species: rat
Cannabinoid receptor activation acutely increases synaptic vesicle numbers by activating synapsins in human synapses.Patzke C, Dai J, Brockmann MM, Sun Z, Fenske P, Rosenmund C, Südhof TC
Molecular psychiatry (2021) : .
105 011 WB; tested species: human
Impact of unilateral ureteral obstruction on cognition and neurodegeneration.Ho YS, Lau CF, Lee K, Tan JY, Lee J, Yung S, Chang RC
Brain research bulletin (2021) 169: 112-127.
105 011 WB; tested species: mouse
Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress.Chanaday NL, Nosyreva E, Shin OH, Zhang H, Aklan I, Atasoy D, Bezprozvanny I, Kavalali ET
Neuron (2021) 1098: 1314-1332.e5.
105 011 WB; tested species: mouse
Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain.Chantranupong L, Saulnier JL, Wang W, Jones DR, Pacold ME, Sabatini BL
eLife (2020) 9: .
105 011 WB; tested species: mouse
VAMP4 maintains a Ca2+-sensitive pool of spontaneously recycling synaptic vesicles.Lin PY, Chanaday NL, Horvath PM, Ramirez DMO, Monteggia LM, Kavalali ET
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : .
105 011 WB; tested species: rat
Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin.Gowrisankaran S, Houy S, Del Castillo JGP, Steubler V, Gelker M, Kroll J, Pinheiro PS, Schwitters D, Halbsgut N, Pechstein A, van Weering JRT, et al.
Nature communications (2020) 111: 1266.
105 011 WB, ICC; tested species: mouse
Synaptotagmin-7 enhances calcium-sensing of chromaffin cell granules and slows discharge of granule cargos.Bendahmane M, Chapman-Morales A, Kreutzberger AJB, Schenk NA, Mohan R, Bakshi S, Philippe J, Zhang S, Kiessling V, Tamm LK, Giovannucci DR, et al.
Journal of neurochemistry (2020) : e14986.
105 011 WB, ICC; tested species: mouse
Intersectin-Mediated Clearance of SNARE Complexes Is Required for Fast Neurotransmission.Jäpel M, Gerth F, Sakaba T, Bacetic J, Yao L, Koo SJ, Maritzen T, Freund C, Haucke V
Cell reports (2020) 302: 409-420.e6.
105 011 WB; tested species: mouse
Abnormal Striatal Development Underlies the Early Onset of Behavioral Deficits in Shank3B-/- Mice.Peixoto RT, Chantranupong L, Hakim R, Levasseur J, Wang W, Merchant T, Gorman K, Budnik B, Sabatini BL
Cell reports (2019) 297: 2016-2027.e4.
105 011 WB; tested species: mouse
In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties.Kreutzberger AJB, Kiessling V, Stroupe C, Liang B, Preobraschenski J, Ganzella M, Kreutzberger MAB, Nakamoto R, Jahn R, Castle JD, Tamm LK, et al.
Nature communications (2019) 101: 3904.
105 011 WB; tested species: rat
Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes.Zurawski Z, Thompson Gray AD, Brady LJ, Page B, Church E, Harris NA, Dohn MR, Yim YY, Hyde K, Mortlock DP, Jones CK, et al.
Science signaling (2019) 12569: .
105 011 WB; tested species: mouse
Expression and secretion of synaptic proteins during stem cell differentiation to cortical neurons.Nazir FH, Becker B, Brinkmalm A, Höglund K, Sandelius Å, Bergström P, Satir TM, Öhrfelt A, Blennow K, Agholme L, Zetterberg H, et al.
Neurochemistry international (2018) : .
105 011 WB, ICC; tested species: human
Two Behavioral Tests Allow a Better Correlation Between Cognitive Function and Expression of Synaptic Proteins.Balietti M, Fattorini G, Pugliese A, Marcotulli D, Bragina L, Conti F
Frontiers in aging neuroscience (2018) 10: 91.
105 011 WB; tested species: rat
Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting.Awasthi A, Ramachandran B, Ahmed S, Benito E, Shinoda Y, Nitzan N, Heukamp A, Rannio S, Martens H, Barth J, Burk K, et al.
Science (New York, N.Y.) (2018) : .
105 011 WB; tested species: rat
The Prion Protein Regulates Synaptic Transmission by Controlling the Expression of Proteins Key to Synaptic Vesicle Recycling and Exocytosis.Peggion C, Stella R, Chemello F, Massimino ML, Arrigoni G, Cagnin S, Biancotto G, Franchin C, Sorgato MC, Bertoli A
Molecular neurobiology (2018) : .
105 011 WB; tested species: mouse
Synaptotagmin oligomerization is essential for calcium control of regulated exocytosis.Bello OD, Jouannot O, Chaudhuri A, Stroeva E, Coleman J, Volynski KE, Rothman JE, Krishnakumar SS
Proceedings of the National Academy of Sciences of the United States of America (2018) 11532: E7624-E7631.
105 011 WB; KO verified; tested species: rat
Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity.Farsi Z, Gowrisankaran S, Krunic M, Rammner B, Woehler A, Lafer EM, Mim C, Jahn R, Milosevic I
eLife (2018) 7: .
105 011 WB; tested species: mouse
Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs.Houy S, Groffen AJ, Ziomkiewicz I, Verhage M, Pinheiro PS, Sørensen JB
eLife (2017) 6: .
105 011 WB; KO verified; tested species: mouse
A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C
The Journal of general physiology (2017) 1491: 149-170.
105 011 ICC, WB
Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease.Lüningschrör P, Binotti B, Dombert B, Heimann P, Perez-Lara A, Slotta C, Thau-Habermann N, R von Collenberg C, Karl F, Damme M, Horowitz A, et al.
Nature communications (2017) 81: 678.
105 011 WB
Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons.Cao M, Wu Y, Ashrafi G, McCartney AJ, Wheeler H, Bushong EA, Boassa D, Ellisman MH, Ryan TA, De Camilli P
Neuron (2017) 934: 882-896.e5.
105 011 WB; tested species: mouse
Analysis of conditional heterozygous STXBP1 mutations in human neurons.Patzke C, Han Y, Covy J, Yi F, Maxeiner S, Wernig M, Südhof TC
The Journal of clinical investigation (2015) 1259: 3560-71.
105 011 WB
Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1.Ciani L, Marzo A, Boyle K, Stamatakou E, Lopes DM, Anane D, McLeod F, Rosso SB, Gibb A, Salinas PC
Nature communications (2015) 6: 8302.
105 011 WB, ICC
The schizophrenia risk gene product miR-137 alters presynaptic plasticity.Siegert S, Seo J, Kwon EJ, Rudenko A, Cho S, Wang W, Flood Z, Martorell AJ, Ericsson M, Mungenast AE, Tsai LH, et al.
Nature neuroscience (2015) 187: 1008-16.
105 011 WB, IHC; tested species: mouse
Vesicular Synaptobrevin/VAMP2 Levels Guarded by AP180 Control Efficient Neurotransmission.Koo SJ, Kochlamazashvili G, Rost B, Puchkov D, Gimber N, Lehmann M, Tadeus G, Schmoranzer J, Rosenmund C, Haucke V, Maritzen T, et al.
Neuron (2015) 882: 330-44.
105 011 WB; tested species: mouse
Ubiquitin-Synaptobrevin Fusion Protein Causes Degeneration of Presynaptic Motor Terminals in Mice.Liu Y, Li H, Sugiura Y, Han W, Gallardo G, Khvotchev M, Zhang Y, Kavalali ET, Südhof TC, Lin W
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3533: 11514-31.
105 011 WB
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8.
105 011 WB
Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes.Jovičić A, Roshan R, Moisoi N, Pradervand S, Moser R, Pillai B, Luthi-Carter R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3312: 5127-37.
105 011 WB; tested species: rat
Small-scale isolation of synaptic vesicles from mammalian brain.Ahmed S, Holt M, Riedel D, Jahn R
Nature protocols (2013) 85: 998-1009.
105 011 WB; tested species: mouse
Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion.Zhou P, Pang ZP, Yang X, Zhang Y, Rosenmund C, Bacaj T, Südhof TC
The EMBO journal (2013) 321: 159-71.
105 011 WB; tested species: mouse
Synaptotagmin-12 phosphorylation by cAMP-dependent protein kinase is essential for hippocampal mossy fiber LTP.Kaeser-Woo YJ, Younts TJ, Yang X, Zhou P, Wu D, Castillo PE, Südhof TC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3323: 9769-80.
105 011 WB
Neurotoxic phospholipases directly affect synaptic vesicle function.Treppmann P, Brunk I, Afube T, Richter K, Ahnert-Hilger G
Journal of neurochemistry (2011) 1174: 757-64.
105 011 WB; tested species: rat
CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity.Sharma M, Burré J, Südhof TC
Nature cell biology (2011) 131: 30-9.
105 011 WB; tested species: mouse
Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7.Xue M, Craig TK, Shin OH, Li L, Brautigam CA, Tomchick DR, Südhof TC, Rosenmund C, Rizo J
PloS one (2010) 59: .
105 011 WB, ICC; tested species: mouse
Calmodulin controls synaptic strength via presynaptic activation of calmodulin kinase II.Pang ZP, Cao P, Xu W, Südhof TC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2010) 3011: 4132-42.
105 011 WB; tested species: mouse
Apolipoproteins D and E3 exert neurotrophic and synaptogenic effects in dorsal root ganglion cell cultures.Kosacka J, Gericke M, Nowicki M, Kacza J, Borlak J, Spanel-Borowski K
Neuroscience (2009) 1622: 282-91.
105 011 WB; tested species: rat
CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins.Jockusch WJ, Speidel D, Sigler A, Sørensen JB, Varoqueaux F, Rhee JS, Brose N
Cell (2007) 1314: 796-808.
105 011 WB
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.Tabuchi K, Blundell J, Etherton MR, Hammer RE, Liu X, Powell CM, Südhof TC
Science (New York, N.Y.) (2007) 3185847: 71-6.
105 011 WB; tested species: mouse
Differential sorting of the vesicular glutamate transporter 1 into a defined vesicular pool is regulated by light signaling involving the clock gene Period2.Yelamanchili SV, Pendyala G, Brunk I, Darna M, Albrecht U, Ahnert-Hilger G
The Journal of biological chemistry (2006) 28123: 15671-9.
105 011 WB; tested species: mouse
Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis.Morciano M, Burré J, Corvey C, Karas M, Zimmermann H, Volknandt W
Journal of neurochemistry (2005) 956: 1732-45.
105 011 WB; tested species: rat
SV2B regulates synaptotagmin 1 by direct interaction.Lazzell DR, Belizaire R, Thakur P, Sherry DM, Janz R
The Journal of biological chemistry (2004) 27950: 52124-31.
105 011 IHC, IP, WB; tested species: mouse
A common mechanism for the regulation of vesicular SNAREs on phospholipid membranes.Hu K, Rickman C, Carroll J, Davletov B
The Biochemical journal (2004) 377Pt 3: 781-5.
105 011 WB
SNAP-23 functions in docking/fusion of granules at low Ca2+.Chieregatti E, Chicka MC, Chapman ER, Baldini G
Molecular biology of the cell (2004) 154: 1918-30.
105 011 WB, IP
Vesicular localization and activity-dependent trafficking of presynaptic choline transporters.Ferguson SM, Savchenko V, Apparsundaram S, Zwick M, Wright J, Heilman CJ, Yi H, Levey AI, Blakely RD
The Journal of neuroscience : the official journal of the Society for Neuroscience (2003) 2330: 9697-709.
105 011 WB; tested species: mouse
Synaptotagmin: a membrane constituent of neuropeptide-containing large dense-core vesicles.Walch-Solimena C, Takei K, Marek KL, Midyett K, Südhof TC, De Camilli P, Jahn R
The Journal of neuroscience : the official journal of the Society for Neuroscience (1993) 139: 3895-903.
105 011 WB, IP