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Home > Products > 114 011

GluN1 antibody extracellular - 114 011 K.O.

GluN1 is the major subunit of ionotropic NMDA type glutamate receptors
Mouse monoclonal purified IgG
Cat. No.: 114 011
Amount: 100 µg
Price: $430.00
Cat. No. 114 011 100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 up to 1 : 10000 (AP staining) gallery  
IP: yes (see remarks)
ICC: 1 : 1000 (see remarks) gallery  
IHC: 1 : 500 (see remarks) gallery  
IHC-P: 1 : 1000 (see remarks) gallery  
IHC-G: (see remarks) gallery  
ExM: 1 : 250 (see remarks) gallery  
ELISA: yes (see remarks)
Clone M68
Subtype IgG2b (κ light chain)
Immunogen Recombinant protein corresponding to AA 660 to 811 from rat GluN1 (UniProt Id: P35439)
Reactivity Reacts with: human (Q05586), rat (P35439), mouse (P35438), zebrafish.
Other species not tested yet.
Specificity K.O. validated PubMed: 24344200
Remarks

IP: For most effective IP, use the denaturing IP-protocol. Consider that protein-protein interactions may be affected.
ICC: Methanol fixation is recommended for standard ICC.

This antibody is also suitable for the surface staining of living cells. After washing cells with bound antibodies, they can be fixed with PFA and visualized with secondary reagents.
IHC: Heat mediated antigen retrieval (AGR) at pH 6,0 is recommended.
IHC-P: Requires heat mediated antigen retrieval at pH 9.0 for 30min at 97°C.
IHC-G: Fixation with 9% glyoxal, 8% acetic acid, in ddH2O, pH 4.2-4.4, according to Konno et al. 2023 is recommended.
ExM: This antibody has been successfully used for the magnified analysis of the proteome (MAP) expansion microscopy method (MAP; Ku et al. 2016. Nature Biotechnology 34:973-981).
This antibody has been successfully used for the epitope-preserving magnified analysis of the proteome (eMAP) expansion microscopy method (Park et al. 2021. PMID: 34767453).
ELISA: Suitable as capture antibody for sandwich-ELISA with cat. no. 114 003 as detector antibody. The ELISA-protocol for membrane proteins is recommended.
Data sheet 114_011.pdf

References for GluN1 - 114 011

Suggestion of creatine as a new neurotransmitter by approaches ranging from chemical analysis and biochemistry to electrophysiology.
Bian X, Zhu J, Jia X, Liang W, Yu S, Li Z, Zhang W, Rao Y
eLife (2023) 12: . 114 011 WB; tested species: mouse
CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling.
Zhu ZA, Li YY, Xu J, Xue H, Feng X, Zhu YC, Xiong ZQ
Cell reports (2023) 4210: 113202. 114 011 WB; tested species: mouse
Neurons undergo pathogenic metabolic reprogramming in models of familial ALS.
Riechers SP, Mojsilovic-Petrovic J, Belton TB, Chakrabarty RP, Garjani M, Medvedeva V, Dalton C, Wong YC, Chandel NS, Dienel G, Kalb RG, et al.
Molecular metabolism (2022) 60: 101468. 114 011 WB, ICC; tested species: rat
Astrocytes Derived from Familial and Sporadic Alzheimer's Disease iPSCs Show Altered Calcium Signaling and Respond Differently to Misfolded Protein Tau.
Brezovakova V, Sykova E, Jadhav S
Cells (2022) 119: . 114 011 WB; tested species: human
Glutamatergic receptor expression changes in the Alzheimer's disease hippocampus and entorhinal cortex.
Yeung JHY, Walby JL, Palpagama TH, Turner C, Waldvogel HJ, Faull RLM, Kwakowsky A
Brain pathology (Zurich, Switzerland) (2021) 316: e13005. 114 011 WB, IHC; tested species: human
Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum.
Chipman PH, Fung CCA, Pazo Fernandez A, Sawant A, Tedoldi A, Kawai A, Ghimire Gautam S, Kurosawa M, Abe M, Sakimura K, Fukai T, et al.
eLife (2021) 10: . 114 011 WB; tested species: mouse
Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors.
Seigneur E, Wang J, Dai J, Polepalli J, Südhof TC
Molecular psychiatry (2021) : . 114 011 WB; tested species: mouse
Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum.
Kuijpers M, Kochlamazashvili G, Stumpf A, Puchkov D, Swaminathan A, Lucht MT, Krause E, Maritzen T, Schmitz D, Haucke V
Neuron (2021) 1092: 299-313.e9. 114 011 WB; tested species: mouse
Targeting PPARα in the rat valproic acid model of autism: focus on social motivational impairment and sex-related differences.
Scheggi S, Guzzi F, Braccagni G, De Montis MG, Parenti M, Gambarana C
Molecular autism (2020) 111: 62. 114 011 WB; tested species: rat
LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses.
Sclip A, Südhof TC
eLife (2020) 9: . 114 011 WB; tested species: mouse
Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain.
Chantranupong L, Saulnier JL, Wang W, Jones DR, Pacold ME, Sabatini BL
eLife (2020) 9: . 114 011 WB; tested species: mouse
BDNF-induced local translation of GluA1 is regulated by HNRNP A2/B1.
Jung Y, Seo JY, Ryu HG, Kim DY, Lee KH, Kim KT
Science advances (2020) 647: . 114 011 WB, ICC; tested species: mouse
Abnormal Striatal Development Underlies the Early Onset of Behavioral Deficits in Shank3B-/- Mice.
Peixoto RT, Chantranupong L, Hakim R, Levasseur J, Wang W, Merchant T, Gorman K, Budnik B, Sabatini BL
Cell reports (2019) 297: 2016-2027.e4. 114 011 WB; tested species: mouse
Kibra Modulates Learning and Memory via Binding to Dendrin.
Ji Z, Li H, Yang Z, Huang X, Ke X, Ma S, Lin Z, Lu Y, Zhang M
Cell reports (2019) 268: 2064-2077.e7. 114 011 WB; tested species: mouse
Development and Characterization of Human Cerebral Organoids: An Optimized Protocol.
Yakoub AM, Sadek M
Cell transplantation (2018) 273: 393-406. 114 011 WB; tested species: human
Hippocampal Memory Recovery After Acute Stress: A Behavioral, Morphological and Molecular Study.
Aguayo FI, Tejos-Bravo M, Díaz-Véliz G, Pacheco A, García-Rojo G, Corrales W, Olave FA, Aliaga E, Ulloa JL, Avalos AM, Román-Albasini L, et al.
Frontiers in molecular neuroscience (2018) 11: 283. 114 011 WB; tested species: rat
Genetic Ablation of All Cerebellins Reveals Synapse Organizer Functions in Multiple Regions Throughout the Brain.
Seigneur E, Südhof TC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3820: 4774-4790. 114 011 WB; tested species: mouse
Isolation of Synaptic Vesicles from Genetically Engineered Cultured Neurons.
McKenzie C, Spanova M, Johnson A, Kainrath S, Zheden V, Sitte HH, Janovjak H
Journal of neuroscience methods (2018) : . 114 011 WB; tested species: rat
SUMO1-conjugation is altered during normal aging but not by increased amyloid burden.
Stankova T, Piepkorn L, Bayer TA, Jahn O, Tirard M
Aging cell (2018) : e12760. 114 011 WB; tested species: mouse
Serotonin Transporter Associated Protein Complexes Are Enriched in Synaptic Vesicle Proteins and Proteins Involved in Energy Metabolism and Ion Homeostasis.
Haase J, Grudzinska-Goebel J, Müller HK, Münster-Wandowski A, Chow E, Wynne K, Farsi Z, Zander JF, Ahnert-Hilger G
ACS chemical neuroscience (2017) 85: 1101-1116. 114 011 WB; tested species: mouse,rat
Analysis of SUMO1-conjugation at synapses.
Daniel JA, Cooper BH, Palvimo JJ, Zhang FP, Brose N, Tirard M
eLife (2017) 6: . 114 011 WB; tested species: mouse
Chronic Stress Triggers Expression of Immediate Early Genes and Differentially Affects the Expression of AMPA and NMDA Subunits in Dorsal and Ventral Hippocampus of Rats.
Pacheco A, Aguayo FI, Aliaga E, Muñoz M, García-Rojo G, Olave FA, Parra-Fiedler NA, García-Pérez A, Tejos-Bravo M, Rojas PS, Parra CS, et al.
Frontiers in molecular neuroscience (2017) 10: 244. 114 011 WB, IHC; tested species: rat
Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice.
Morimura N, Yasuda H, Yamaguchi K, Katayama KI, Hatayama M, Tomioka NH, Odagawa M, Kamiya A, Iwayama Y, Maekawa M, Nakamura K, et al.
Nature communications (2017) 8: 15800. 114 011 WB; tested species: mouse
Distinct Defects in Synaptic Differentiation of Neocortical Neurons in Response to Prenatal Valproate Exposure.
Iijima Y, Behr K, Iijima T, Biemans B, Bischofberger J, Scheiffele P
Scientific reports (2016) 6: 27400. 114 011 WB
Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking.
Wang SSH, Held RG, Wong MY, Liu C, Karakhanyan A, Kaeser PS
Neuron (2016) 914: 777-791. 114 011 WB, ICC
STIM2 regulates PKA-dependent phosphorylation and trafficking of AMPARs.
Garcia-Alvarez G, Lu B, Yap KA, Wong LC, Thevathasan JV, Lim L, Ji F, Tan KW, Mancuso JJ, Tang W, Poon SY, et al.
Molecular biology of the cell (2015) 266: 1141-59. 114 011 WB
Neuroligin-1 regulates excitatory synaptic transmission, LTP and EPSP-spike coupling in the dentate gyrus in vivo.
Jedlicka P, Vnencak M, Krueger DD, Jungenitz T, Brose N, Schwarzacher SW
Brain structure & function (2015) 2201: 47-58. 114 011 WB
Pregnenolone sulfate normalizes schizophrenia-like behaviors in dopamine transporter knockout mice through the AKT/GSK3β pathway.
Wong P, Sze Y, Chang CC, Lee J, Zhang X
Translational psychiatry (2015) 5: e528. 114 011 WB
Activity-Dependent Bidirectional Regulation of GAD Expression in a Homeostatic Fashion Is Mediated by BDNF-Dependent and Independent Pathways.
Hanno-Iijima Y, Tanaka M, Iijima T
PloS one (2015) 108: e0134296. 114 011 WB
Parental THC exposure leads to compulsive heroin-seeking and altered striatal synaptic plasticity in the subsequent generation.
Szutorisz H, DiNieri JA, Sweet E, Egervari G, Michaelides M, Carter JM, Ren Y, Miller ML, Blitzer RD, Hurd YL
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (2014) 396: 1315-23. 114 011 WB; tested species: rat
Synaptic function of nicastrin in hippocampal neurons.
Lee SH, Sharma M, Südhof TC, Shen J
Proceedings of the National Academy of Sciences of the United States of America (2014) 11124: 8973-8. 114 011 WB; tested species: mouse
NMDA receptors are upregulated and trafficked to the plasma membrane after sigma-1 receptor activation in the rat hippocampus.
Pabba M, Wong AY, Ahlskog N, Hristova E, Biscaro D, Nassrallah W, Ngsee JK, Snyder M, Beique JC, Bergeron R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3434: 11325-38. 114 011 WB
Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting.
Biesemann C, Grønborg M, Luquet E, Wichert SP, Bernard V, Bungers SR, Cooper B, Varoqueaux F, Li L, Byrne JA, Urlaub H, et al.
The EMBO journal (2014) 332: 157-70. 114 011 WB; tested species: mouse
Immunosuppression by N-methyl-D-aspartate receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells.
Kahlfuß S, Simma N, Mankiewicz J, Bose T, Lowinus T, Klein-Hessling S, Sprengel R, Schraven B, Heine M, Bommhardt U
Molecular and cellular biology (2014) 345: 820-31. 114 011 WB; KO verified; tested species: mouse
Differential subcellular targeting of glutamate receptor subtypes during homeostatic synaptic plasticity.
Soares C, Lee KF, Nassrallah W, Béïque JC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3333: 13547-59. 114 011 WB; tested species: mouse
Disruption of Arp2/3 results in asymmetric structural plasticity of dendritic spines and progressive synaptic and behavioral abnormalities.
Kim IH, Racz B, Wang H, Burianek L, Weinberg R, Yasuda R, Wetsel WC, Soderling SH
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3314: 6081-92. 114 011 WB; tested species: mouse
Small-scale isolation of synaptic vesicles from mammalian brain.
Ahmed S, Holt M, Riedel D, Jahn R
Nature protocols (2013) 85: 998-1009. 114 011 WB; tested species: mouse
SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients.
Shcheglovitov A, Shcheglovitova O, Yazawa M, Portmann T, Shu R, Sebastiano V, Krawisz A, Froehlich W, Bernstein JA, Hallmayer JF, Dolmetsch RE, et al.
Nature (2013) 5037475: 267-71. 114 011 WB; tested species: human
IκB kinase/nuclear factor κB-dependent insulin-like growth factor 2 (Igf2) expression regulates synapse formation and spine maturation via Igf2 receptor signaling.
Schmeisser MJ, Baumann B, Johannsen S, Vindedal GF, Jensen V, Hvalby ØC, Sprengel R, Seither J, Maqbool A, Magnutzki A, Lattke M, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3216: 5688-703. 114 011 WB; tested species: mouse
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.
Tabuchi K, Blundell J, Etherton MR, Hammer RE, Liu X, Powell CM, Südhof TC
Science (New York, N.Y.) (2007) 3185847: 71-6. 114 011 WB; tested species: mouse
Involvement of myosin Vb in glutamate receptor trafficking.
Lisé MF, Wong TP, Trinh A, Hines RM, Liu L, Kang R, Hines DJ, Lu J, Goldenring JR, Wang YT, El-Husseini A, et al.
The Journal of biological chemistry (2006) 2816: 3669-78. 114 011 WB, ICC
Homo- and heterodimerization of APP family members promotes intercellular adhesion.
Soba P, Eggert S, Wagner K, Zentgraf H, Siehl K, Kreger S, Löwer A, Langer A, Merdes G, Paro R, Masters CL, et al.
The EMBO journal (2005) 2420: 3624-34. 114 011 WB
Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex.
Olsen O, Moore KA, Fukata M, Kazuta T, Trinidad JC, Kauer FW, Streuli M, Misawa H, Burlingame AL, Nicoll RA, Bredt DS, et al.
The Journal of cell biology (2005) 1707: 1127-34. 114 011 WB
An essential role for vesicular glutamate transporter 1 (VGLUT1) in postnatal development and control of quantal size.
Wojcik SM, Rhee JS, Herzog E, Sigler A, Jahn R, Takamori S, Brose N, Rosenmund C
Proceedings of the National Academy of Sciences of the United States of America (2004) 10118: 7158-63. 114 011 WB; tested species: mouse
Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins.
Kattenstroth G, Tantalaki E, Südhof TC, Gottmann K, Missler M
Proceedings of the National Academy of Sciences of the United States of America (2004) 1018: 2607-12. 114 011 WB
Neurons undergo pathogenic metabolic reprogramming in models of familial ALS.
Riechers SP, Mojsilovic-Petrovic J, Belton TB, Chakrabarty RP, Garjani M, Medvedeva V, Dalton C, Wong YC, Chandel NS, Dienel G, Kalb RG, et al.
Molecular metabolism (2022) 60: 101468. 114 011 WB, ICC; tested species: rat
BDNF-induced local translation of GluA1 is regulated by HNRNP A2/B1.
Jung Y, Seo JY, Ryu HG, Kim DY, Lee KH, Kim KT
Science advances (2020) 647: . 114 011 WB, ICC; tested species: mouse
Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons.
Ripamonti S, Ambrozkiewicz MC, Guzzi F, Gravati M, Biella G, Bormuth I, Hammer M, Tuffy LP, Sigler A, Kawabe H, Nishimori K, et al.
eLife (2017) 6: . 114 011 ICC; tested species: mouse
Evidence for a role of glycoprotein M6a in dendritic spine formation and synaptogenesis.
Formoso K, Garcia MD, Frasch AC, Scorticati C
Molecular and cellular neurosciences (2016) 77: 95-104. 114 011 ICC; tested species: mouse
Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking.
Wang SSH, Held RG, Wong MY, Liu C, Karakhanyan A, Kaeser PS
Neuron (2016) 914: 777-791. 114 011 WB, ICC
Anti-NMDA Receptor Encephalitis in the Polar Bear (Ursus maritimus) Knut.
Prüss H, Leubner J, Wenke NK, Czirják GÁ, Szentiks CA, Greenwood AD
Scientific reports (2015) 5: 12805. 114 011 ICC, IHC
Coexistence of glutamatergic spine synapses and shaft synapses in substantia nigra dopamine neurons.
Jang M, Um KB, Jang J, Kim HJ, Cho H, Chung S, Park MK
Scientific reports (2015) 5: 14773. 114 011 ICC
Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1.
Ciani L, Marzo A, Boyle K, Stamatakou E, Lopes DM, Anane D, McLeod F, Rosso SB, Gibb A, Salinas PC
Nature communications (2015) 6: 8302. 114 011 ICC
Activity-dependent spine morphogenesis: a role for the actin-capping protein Eps8.
Stamatakou E, Marzo A, Gibb A, Salinas PC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 336: 2661-70. 114 011 ICC; tested species: rat
Involvement of myosin Vb in glutamate receptor trafficking.
Lisé MF, Wong TP, Trinh A, Hines RM, Liu L, Kang R, Hines DJ, Lu J, Goldenring JR, Wang YT, El-Husseini A, et al.
The Journal of biological chemistry (2006) 2816: 3669-78. 114 011 WB, ICC
Control of excitatory and inhibitory synapse formation by neuroligins.
Chih B, Engelman H, Scheiffele P
Science (New York, N.Y.) (2005) 3075713: 1324-8. 114 011 ICC
Differential targeting of the L-type Ca2+ channel alpha 1C (CaV1.2) to synaptic and extrasynaptic compartments in hippocampal neurons.
Obermair GJ, Szabo Z, Bourinet E, Flucher BE
The European journal of neuroscience (2004) 198: 2109-22. 114 011 ICC; tested species: mouse
The small conductance Ca2+-activated K+ channel SK3 is localized in nerve terminals of excitatory synapses of cultured mouse hippocampal neurons.
Obermair GJ, Kaufmann WA, Knaus HG, Flucher BE
The European journal of neuroscience (2003) 174: 721-31. 114 011 ICC
Synaptic communication mediates the assembly of a self-organizing circuit that controls reproduction.
Golan M, Boulanger-Weill J, Pinot A, Fontanaud P, Faucherre A, Gajbhiye DS, Hollander-Cohen L, Fiordelisio-Coll T, Martin AO, Mollard P
Science advances (2021) 78: . 114 011 IHC; tested species: zebrafish
Glutamatergic receptor expression changes in the Alzheimer's disease hippocampus and entorhinal cortex.
Yeung JHY, Walby JL, Palpagama TH, Turner C, Waldvogel HJ, Faull RLM, Kwakowsky A
Brain pathology (Zurich, Switzerland) (2021) 316: e13005. 114 011 WB, IHC; tested species: human
Altered Visual Function in a Larval Zebrafish Knockout of Neurodevelopmental Risk Gene pdzk1.
Xie J, Jusuf PR, Bui BV, Dudczig S, Sztal TE, Goodbourn PT
Investigative ophthalmology & visual science (2021) 623: 29. 114 011 IHC; tested species: zebrafish
Amyloid-beta1-42 induced glutamatergic receptor and transporter expression changes in the mouse hippocampus.
Yeung JHY, Calvo-Flores Guzmán B, Palpagama TH, Ethiraj J, Zhai Y, Tate WP, Peppercorn K, Waldvogel HJ, Faull RLM, Kwakowsky A
Journal of neurochemistry (2020) 1551: 62-80. 114 011 IHC; tested species: mouse
Analysis of Synapses in Cerebral Organoids.
Yakoub AM, Sadek M
Cell transplantation (2019) : 963689718822811. 114 011 IHC; tested species: human
The Acute Effects of Amyloid-Beta1-42 on Glutamatergic Receptor and Transporter Expression in the Mouse Hippocampus.
Yeung JHY, Palpagama TH, Tate WP, Peppercorn K, Waldvogel HJ, Faull RLM, Kwakowsky A
Frontiers in neuroscience (2019) 13: 1427. 114 011 IHC; tested species: mouse
Chronic Stress Triggers Expression of Immediate Early Genes and Differentially Affects the Expression of AMPA and NMDA Subunits in Dorsal and Ventral Hippocampus of Rats.
Pacheco A, Aguayo FI, Aliaga E, Muñoz M, García-Rojo G, Olave FA, Parra-Fiedler NA, García-Pérez A, Tejos-Bravo M, Rojas PS, Parra CS, et al.
Frontiers in molecular neuroscience (2017) 10: 244. 114 011 WB, IHC; tested species: rat
Anti-NMDA Receptor Encephalitis in the Polar Bear (Ursus maritimus) Knut.
Prüss H, Leubner J, Wenke NK, Czirják GÁ, Szentiks CA, Greenwood AD
Scientific reports (2015) 5: 12805. 114 011 ICC, IHC
Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.
Trimbuch T, Beed P, Vogt J, Schuchmann S, Maier N, Kintscher M, Breustedt J, Schuelke M, Streu N, Kieselmann O, Brunk I, et al.
Cell (2009) 1386: 1222-35. 114 011 IHC
The role of N-methyl-D-aspartate receptor subunits in the rat thalamic mediodorsal nucleus during central sensitization.
Kaneko M, Kaneko T, Kaneko R, Chokechanachaisakul U, Kawamura J, Sunakawa M, Okiji T, Suda H
Brain research (2011) 1371: 16-22. 114 011 IHC-P; tested species: rat
Neuron-immune interactions in the sensitized thalamus induced by mustard oil application to rat molar pulp.
Kawamura J, Kaneko T, Kaneko M, Sunakawa M, Kaneko R, Chokechanachaisakul U, Okiji T, Suda H
Journal of dental research (2010) 8911: 1309-14. 114 011 IHC-P; tested species: rat
Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission.
Vasileva M, Horstmann H, Geumann C, Gitler D, Kuner T
The European journal of neuroscience (2012) 368: 3005-20. 114 011 ELISA
Sustained calcium signalling and caspase-3 activation involve NMDA receptors in thymocytes in contact with dendritic cells.
Affaticati P, Mignen O, Jambou F, Potier MC, Klingel-Schmitt I, Degrouard J, Peineau S, Gouadon E, Collingridge GL, Liblau R, Capiod T, et al.
Cell death and differentiation (2011) 181: 99-108. 114 011 FACS
Endosomal sorting of readily releasable synaptic vesicles.
Hoopmann P, Punge A, Barysch SV, Westphal V, Bückers J, Opazo F, Bethani I, Lauterbach MA, Hell SW, Rizzoli SO
Proceedings of the National Academy of Sciences of the United States of America (2010) 10744: 19055-60. 114 011
Cat. No.: 114 011
Amount: 100 µg
Price: $430.00
Suggestion of creatine as a new neurotransmitter by approaches ranging from chemical analysis and biochemistry to electrophysiology.
Bian X, Zhu J, Jia X, Liang W, Yu S, Li Z, Zhang W, Rao Y
eLife (2023) 12: . 114 011 WB; tested species: mouse
CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling.
Zhu ZA, Li YY, Xu J, Xue H, Feng X, Zhu YC, Xiong ZQ
Cell reports (2023) 4210: 113202. 114 011 WB; tested species: mouse
Neurons undergo pathogenic metabolic reprogramming in models of familial ALS.
Riechers SP, Mojsilovic-Petrovic J, Belton TB, Chakrabarty RP, Garjani M, Medvedeva V, Dalton C, Wong YC, Chandel NS, Dienel G, Kalb RG, et al.
Molecular metabolism (2022) 60: 101468. 114 011 WB, ICC; tested species: rat
Astrocytes Derived from Familial and Sporadic Alzheimer's Disease iPSCs Show Altered Calcium Signaling and Respond Differently to Misfolded Protein Tau.
Brezovakova V, Sykova E, Jadhav S
Cells (2022) 119: . 114 011 WB; tested species: human
Glutamatergic receptor expression changes in the Alzheimer's disease hippocampus and entorhinal cortex.
Yeung JHY, Walby JL, Palpagama TH, Turner C, Waldvogel HJ, Faull RLM, Kwakowsky A
Brain pathology (Zurich, Switzerland) (2021) 316: e13005. 114 011 WB, IHC; tested species: human
Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum.
Chipman PH, Fung CCA, Pazo Fernandez A, Sawant A, Tedoldi A, Kawai A, Ghimire Gautam S, Kurosawa M, Abe M, Sakimura K, Fukai T, et al.
eLife (2021) 10: . 114 011 WB; tested species: mouse
Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors.
Seigneur E, Wang J, Dai J, Polepalli J, Südhof TC
Molecular psychiatry (2021) : . 114 011 WB; tested species: mouse
Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum.
Kuijpers M, Kochlamazashvili G, Stumpf A, Puchkov D, Swaminathan A, Lucht MT, Krause E, Maritzen T, Schmitz D, Haucke V
Neuron (2021) 1092: 299-313.e9. 114 011 WB; tested species: mouse
Targeting PPARα in the rat valproic acid model of autism: focus on social motivational impairment and sex-related differences.
Scheggi S, Guzzi F, Braccagni G, De Montis MG, Parenti M, Gambarana C
Molecular autism (2020) 111: 62. 114 011 WB; tested species: rat
LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses.
Sclip A, Südhof TC
eLife (2020) 9: . 114 011 WB; tested species: mouse
Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain.
Chantranupong L, Saulnier JL, Wang W, Jones DR, Pacold ME, Sabatini BL
eLife (2020) 9: . 114 011 WB; tested species: mouse
BDNF-induced local translation of GluA1 is regulated by HNRNP A2/B1.
Jung Y, Seo JY, Ryu HG, Kim DY, Lee KH, Kim KT
Science advances (2020) 647: . 114 011 WB, ICC; tested species: mouse
Abnormal Striatal Development Underlies the Early Onset of Behavioral Deficits in Shank3B-/- Mice.
Peixoto RT, Chantranupong L, Hakim R, Levasseur J, Wang W, Merchant T, Gorman K, Budnik B, Sabatini BL
Cell reports (2019) 297: 2016-2027.e4. 114 011 WB; tested species: mouse
Kibra Modulates Learning and Memory via Binding to Dendrin.
Ji Z, Li H, Yang Z, Huang X, Ke X, Ma S, Lin Z, Lu Y, Zhang M
Cell reports (2019) 268: 2064-2077.e7. 114 011 WB; tested species: mouse
Development and Characterization of Human Cerebral Organoids: An Optimized Protocol.
Yakoub AM, Sadek M
Cell transplantation (2018) 273: 393-406. 114 011 WB; tested species: human
Hippocampal Memory Recovery After Acute Stress: A Behavioral, Morphological and Molecular Study.
Aguayo FI, Tejos-Bravo M, Díaz-Véliz G, Pacheco A, García-Rojo G, Corrales W, Olave FA, Aliaga E, Ulloa JL, Avalos AM, Román-Albasini L, et al.
Frontiers in molecular neuroscience (2018) 11: 283. 114 011 WB; tested species: rat
Genetic Ablation of All Cerebellins Reveals Synapse Organizer Functions in Multiple Regions Throughout the Brain.
Seigneur E, Südhof TC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3820: 4774-4790. 114 011 WB; tested species: mouse
Isolation of Synaptic Vesicles from Genetically Engineered Cultured Neurons.
McKenzie C, Spanova M, Johnson A, Kainrath S, Zheden V, Sitte HH, Janovjak H
Journal of neuroscience methods (2018) : . 114 011 WB; tested species: rat
SUMO1-conjugation is altered during normal aging but not by increased amyloid burden.
Stankova T, Piepkorn L, Bayer TA, Jahn O, Tirard M
Aging cell (2018) : e12760. 114 011 WB; tested species: mouse
Serotonin Transporter Associated Protein Complexes Are Enriched in Synaptic Vesicle Proteins and Proteins Involved in Energy Metabolism and Ion Homeostasis.
Haase J, Grudzinska-Goebel J, Müller HK, Münster-Wandowski A, Chow E, Wynne K, Farsi Z, Zander JF, Ahnert-Hilger G
ACS chemical neuroscience (2017) 85: 1101-1116. 114 011 WB; tested species: mouse,rat
Analysis of SUMO1-conjugation at synapses.
Daniel JA, Cooper BH, Palvimo JJ, Zhang FP, Brose N, Tirard M
eLife (2017) 6: . 114 011 WB; tested species: mouse
Chronic Stress Triggers Expression of Immediate Early Genes and Differentially Affects the Expression of AMPA and NMDA Subunits in Dorsal and Ventral Hippocampus of Rats.
Pacheco A, Aguayo FI, Aliaga E, Muñoz M, García-Rojo G, Olave FA, Parra-Fiedler NA, García-Pérez A, Tejos-Bravo M, Rojas PS, Parra CS, et al.
Frontiers in molecular neuroscience (2017) 10: 244. 114 011 WB, IHC; tested species: rat
Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice.
Morimura N, Yasuda H, Yamaguchi K, Katayama KI, Hatayama M, Tomioka NH, Odagawa M, Kamiya A, Iwayama Y, Maekawa M, Nakamura K, et al.
Nature communications (2017) 8: 15800. 114 011 WB; tested species: mouse
Distinct Defects in Synaptic Differentiation of Neocortical Neurons in Response to Prenatal Valproate Exposure.
Iijima Y, Behr K, Iijima T, Biemans B, Bischofberger J, Scheiffele P
Scientific reports (2016) 6: 27400. 114 011 WB
Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking.
Wang SSH, Held RG, Wong MY, Liu C, Karakhanyan A, Kaeser PS
Neuron (2016) 914: 777-791. 114 011 WB, ICC
STIM2 regulates PKA-dependent phosphorylation and trafficking of AMPARs.
Garcia-Alvarez G, Lu B, Yap KA, Wong LC, Thevathasan JV, Lim L, Ji F, Tan KW, Mancuso JJ, Tang W, Poon SY, et al.
Molecular biology of the cell (2015) 266: 1141-59. 114 011 WB
Neuroligin-1 regulates excitatory synaptic transmission, LTP and EPSP-spike coupling in the dentate gyrus in vivo.
Jedlicka P, Vnencak M, Krueger DD, Jungenitz T, Brose N, Schwarzacher SW
Brain structure & function (2015) 2201: 47-58. 114 011 WB
Pregnenolone sulfate normalizes schizophrenia-like behaviors in dopamine transporter knockout mice through the AKT/GSK3β pathway.
Wong P, Sze Y, Chang CC, Lee J, Zhang X
Translational psychiatry (2015) 5: e528. 114 011 WB
Activity-Dependent Bidirectional Regulation of GAD Expression in a Homeostatic Fashion Is Mediated by BDNF-Dependent and Independent Pathways.
Hanno-Iijima Y, Tanaka M, Iijima T
PloS one (2015) 108: e0134296. 114 011 WB
Parental THC exposure leads to compulsive heroin-seeking and altered striatal synaptic plasticity in the subsequent generation.
Szutorisz H, DiNieri JA, Sweet E, Egervari G, Michaelides M, Carter JM, Ren Y, Miller ML, Blitzer RD, Hurd YL
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (2014) 396: 1315-23. 114 011 WB; tested species: rat
Synaptic function of nicastrin in hippocampal neurons.
Lee SH, Sharma M, Südhof TC, Shen J
Proceedings of the National Academy of Sciences of the United States of America (2014) 11124: 8973-8. 114 011 WB; tested species: mouse
NMDA receptors are upregulated and trafficked to the plasma membrane after sigma-1 receptor activation in the rat hippocampus.
Pabba M, Wong AY, Ahlskog N, Hristova E, Biscaro D, Nassrallah W, Ngsee JK, Snyder M, Beique JC, Bergeron R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3434: 11325-38. 114 011 WB
Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting.
Biesemann C, Grønborg M, Luquet E, Wichert SP, Bernard V, Bungers SR, Cooper B, Varoqueaux F, Li L, Byrne JA, Urlaub H, et al.
The EMBO journal (2014) 332: 157-70. 114 011 WB; tested species: mouse
Immunosuppression by N-methyl-D-aspartate receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells.
Kahlfuß S, Simma N, Mankiewicz J, Bose T, Lowinus T, Klein-Hessling S, Sprengel R, Schraven B, Heine M, Bommhardt U
Molecular and cellular biology (2014) 345: 820-31. 114 011 WB; KO verified; tested species: mouse
Differential subcellular targeting of glutamate receptor subtypes during homeostatic synaptic plasticity.
Soares C, Lee KF, Nassrallah W, Béïque JC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3333: 13547-59. 114 011 WB; tested species: mouse
Disruption of Arp2/3 results in asymmetric structural plasticity of dendritic spines and progressive synaptic and behavioral abnormalities.
Kim IH, Racz B, Wang H, Burianek L, Weinberg R, Yasuda R, Wetsel WC, Soderling SH
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3314: 6081-92. 114 011 WB; tested species: mouse
Small-scale isolation of synaptic vesicles from mammalian brain.
Ahmed S, Holt M, Riedel D, Jahn R
Nature protocols (2013) 85: 998-1009. 114 011 WB; tested species: mouse
SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients.
Shcheglovitov A, Shcheglovitova O, Yazawa M, Portmann T, Shu R, Sebastiano V, Krawisz A, Froehlich W, Bernstein JA, Hallmayer JF, Dolmetsch RE, et al.
Nature (2013) 5037475: 267-71. 114 011 WB; tested species: human
IκB kinase/nuclear factor κB-dependent insulin-like growth factor 2 (Igf2) expression regulates synapse formation and spine maturation via Igf2 receptor signaling.
Schmeisser MJ, Baumann B, Johannsen S, Vindedal GF, Jensen V, Hvalby ØC, Sprengel R, Seither J, Maqbool A, Magnutzki A, Lattke M, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3216: 5688-703. 114 011 WB; tested species: mouse
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.
Tabuchi K, Blundell J, Etherton MR, Hammer RE, Liu X, Powell CM, Südhof TC
Science (New York, N.Y.) (2007) 3185847: 71-6. 114 011 WB; tested species: mouse
Involvement of myosin Vb in glutamate receptor trafficking.
Lisé MF, Wong TP, Trinh A, Hines RM, Liu L, Kang R, Hines DJ, Lu J, Goldenring JR, Wang YT, El-Husseini A, et al.
The Journal of biological chemistry (2006) 2816: 3669-78. 114 011 WB, ICC
Homo- and heterodimerization of APP family members promotes intercellular adhesion.
Soba P, Eggert S, Wagner K, Zentgraf H, Siehl K, Kreger S, Löwer A, Langer A, Merdes G, Paro R, Masters CL, et al.
The EMBO journal (2005) 2420: 3624-34. 114 011 WB
Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex.
Olsen O, Moore KA, Fukata M, Kazuta T, Trinidad JC, Kauer FW, Streuli M, Misawa H, Burlingame AL, Nicoll RA, Bredt DS, et al.
The Journal of cell biology (2005) 1707: 1127-34. 114 011 WB
An essential role for vesicular glutamate transporter 1 (VGLUT1) in postnatal development and control of quantal size.
Wojcik SM, Rhee JS, Herzog E, Sigler A, Jahn R, Takamori S, Brose N, Rosenmund C
Proceedings of the National Academy of Sciences of the United States of America (2004) 10118: 7158-63. 114 011 WB; tested species: mouse
Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins.
Kattenstroth G, Tantalaki E, Südhof TC, Gottmann K, Missler M
Proceedings of the National Academy of Sciences of the United States of America (2004) 1018: 2607-12. 114 011 WB
Neurons undergo pathogenic metabolic reprogramming in models of familial ALS.
Riechers SP, Mojsilovic-Petrovic J, Belton TB, Chakrabarty RP, Garjani M, Medvedeva V, Dalton C, Wong YC, Chandel NS, Dienel G, Kalb RG, et al.
Molecular metabolism (2022) 60: 101468. 114 011 WB, ICC; tested species: rat
BDNF-induced local translation of GluA1 is regulated by HNRNP A2/B1.
Jung Y, Seo JY, Ryu HG, Kim DY, Lee KH, Kim KT
Science advances (2020) 647: . 114 011 WB, ICC; tested species: mouse
Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons.
Ripamonti S, Ambrozkiewicz MC, Guzzi F, Gravati M, Biella G, Bormuth I, Hammer M, Tuffy LP, Sigler A, Kawabe H, Nishimori K, et al.
eLife (2017) 6: . 114 011 ICC; tested species: mouse
Evidence for a role of glycoprotein M6a in dendritic spine formation and synaptogenesis.
Formoso K, Garcia MD, Frasch AC, Scorticati C
Molecular and cellular neurosciences (2016) 77: 95-104. 114 011 ICC; tested species: mouse
Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking.
Wang SSH, Held RG, Wong MY, Liu C, Karakhanyan A, Kaeser PS
Neuron (2016) 914: 777-791. 114 011 WB, ICC
Anti-NMDA Receptor Encephalitis in the Polar Bear (Ursus maritimus) Knut.
Prüss H, Leubner J, Wenke NK, Czirják GÁ, Szentiks CA, Greenwood AD
Scientific reports (2015) 5: 12805. 114 011 ICC, IHC
Coexistence of glutamatergic spine synapses and shaft synapses in substantia nigra dopamine neurons.
Jang M, Um KB, Jang J, Kim HJ, Cho H, Chung S, Park MK
Scientific reports (2015) 5: 14773. 114 011 ICC
Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1.
Ciani L, Marzo A, Boyle K, Stamatakou E, Lopes DM, Anane D, McLeod F, Rosso SB, Gibb A, Salinas PC
Nature communications (2015) 6: 8302. 114 011 ICC
Activity-dependent spine morphogenesis: a role for the actin-capping protein Eps8.
Stamatakou E, Marzo A, Gibb A, Salinas PC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 336: 2661-70. 114 011 ICC; tested species: rat
Involvement of myosin Vb in glutamate receptor trafficking.
Lisé MF, Wong TP, Trinh A, Hines RM, Liu L, Kang R, Hines DJ, Lu J, Goldenring JR, Wang YT, El-Husseini A, et al.
The Journal of biological chemistry (2006) 2816: 3669-78. 114 011 WB, ICC
Control of excitatory and inhibitory synapse formation by neuroligins.
Chih B, Engelman H, Scheiffele P
Science (New York, N.Y.) (2005) 3075713: 1324-8. 114 011 ICC
Differential targeting of the L-type Ca2+ channel alpha 1C (CaV1.2) to synaptic and extrasynaptic compartments in hippocampal neurons.
Obermair GJ, Szabo Z, Bourinet E, Flucher BE
The European journal of neuroscience (2004) 198: 2109-22. 114 011 ICC; tested species: mouse
The small conductance Ca2+-activated K+ channel SK3 is localized in nerve terminals of excitatory synapses of cultured mouse hippocampal neurons.
Obermair GJ, Kaufmann WA, Knaus HG, Flucher BE
The European journal of neuroscience (2003) 174: 721-31. 114 011 ICC
Synaptic communication mediates the assembly of a self-organizing circuit that controls reproduction.
Golan M, Boulanger-Weill J, Pinot A, Fontanaud P, Faucherre A, Gajbhiye DS, Hollander-Cohen L, Fiordelisio-Coll T, Martin AO, Mollard P
Science advances (2021) 78: . 114 011 IHC; tested species: zebrafish
Glutamatergic receptor expression changes in the Alzheimer's disease hippocampus and entorhinal cortex.
Yeung JHY, Walby JL, Palpagama TH, Turner C, Waldvogel HJ, Faull RLM, Kwakowsky A
Brain pathology (Zurich, Switzerland) (2021) 316: e13005. 114 011 WB, IHC; tested species: human
Altered Visual Function in a Larval Zebrafish Knockout of Neurodevelopmental Risk Gene pdzk1.
Xie J, Jusuf PR, Bui BV, Dudczig S, Sztal TE, Goodbourn PT
Investigative ophthalmology & visual science (2021) 623: 29. 114 011 IHC; tested species: zebrafish
Amyloid-beta1-42 induced glutamatergic receptor and transporter expression changes in the mouse hippocampus.
Yeung JHY, Calvo-Flores Guzmán B, Palpagama TH, Ethiraj J, Zhai Y, Tate WP, Peppercorn K, Waldvogel HJ, Faull RLM, Kwakowsky A
Journal of neurochemistry (2020) 1551: 62-80. 114 011 IHC; tested species: mouse
Analysis of Synapses in Cerebral Organoids.
Yakoub AM, Sadek M
Cell transplantation (2019) : 963689718822811. 114 011 IHC; tested species: human
The Acute Effects of Amyloid-Beta1-42 on Glutamatergic Receptor and Transporter Expression in the Mouse Hippocampus.
Yeung JHY, Palpagama TH, Tate WP, Peppercorn K, Waldvogel HJ, Faull RLM, Kwakowsky A
Frontiers in neuroscience (2019) 13: 1427. 114 011 IHC; tested species: mouse
Chronic Stress Triggers Expression of Immediate Early Genes and Differentially Affects the Expression of AMPA and NMDA Subunits in Dorsal and Ventral Hippocampus of Rats.
Pacheco A, Aguayo FI, Aliaga E, Muñoz M, García-Rojo G, Olave FA, Parra-Fiedler NA, García-Pérez A, Tejos-Bravo M, Rojas PS, Parra CS, et al.
Frontiers in molecular neuroscience (2017) 10: 244. 114 011 WB, IHC; tested species: rat
Anti-NMDA Receptor Encephalitis in the Polar Bear (Ursus maritimus) Knut.
Prüss H, Leubner J, Wenke NK, Czirják GÁ, Szentiks CA, Greenwood AD
Scientific reports (2015) 5: 12805. 114 011 ICC, IHC
Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.
Trimbuch T, Beed P, Vogt J, Schuchmann S, Maier N, Kintscher M, Breustedt J, Schuelke M, Streu N, Kieselmann O, Brunk I, et al.
Cell (2009) 1386: 1222-35. 114 011 IHC
The role of N-methyl-D-aspartate receptor subunits in the rat thalamic mediodorsal nucleus during central sensitization.
Kaneko M, Kaneko T, Kaneko R, Chokechanachaisakul U, Kawamura J, Sunakawa M, Okiji T, Suda H
Brain research (2011) 1371: 16-22. 114 011 IHC-P; tested species: rat
Neuron-immune interactions in the sensitized thalamus induced by mustard oil application to rat molar pulp.
Kawamura J, Kaneko T, Kaneko M, Sunakawa M, Kaneko R, Chokechanachaisakul U, Okiji T, Suda H
Journal of dental research (2010) 8911: 1309-14. 114 011 IHC-P; tested species: rat
Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission.
Vasileva M, Horstmann H, Geumann C, Gitler D, Kuner T
The European journal of neuroscience (2012) 368: 3005-20. 114 011 ELISA
Sustained calcium signalling and caspase-3 activation involve NMDA receptors in thymocytes in contact with dendritic cells.
Affaticati P, Mignen O, Jambou F, Potier MC, Klingel-Schmitt I, Degrouard J, Peineau S, Gouadon E, Collingridge GL, Liblau R, Capiod T, et al.
Cell death and differentiation (2011) 181: 99-108. 114 011 FACS
Endosomal sorting of readily releasable synaptic vesicles.
Hoopmann P, Punge A, Barysch SV, Westphal V, Bückers J, Opazo F, Bethani I, Lauterbach MA, Hell SW, Rizzoli SO
Proceedings of the National Academy of Sciences of the United States of America (2010) 10744: 19055-60. 114 011
WB
ICC
ICC
IHC
IHC-P
IHC-P
IHC-G
IHC-G
ExM
ExM
Background

GluNs (NMDA-receptors) represent a class of glutamate receptors that are of central importance in synaptic plasticity. Multiple NMDA receptor subtypes exist: GluN1 and GluN2 A-D. GluN1 is the most important as it is required for activity. NMDA-receptors allow Ca2+ influx and are thought to trigger Ca2+ dependent postsynaptic processes involved in long term potentiation and depression.
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