Spinophilin peptide - 399-0P

Spinophilin is enriched at dendritic spines

control peptide

Cat. No.: 399-0P

Amount: 100 µg

Price: $110.00

Cat. No. 399-0P	100 µg peptide, lyophilized. For reconstitution add 100 µl H₂O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Control peptides should be stored at -20°C when still lyophilized!
Applications
Immunogen	Synthetic peptide corresponding to AA 290 to 302 from rat Spinophilin (UniProt Id: O35274)
Matching antibodies	399 003, 399 005
Data sheet	Datasheet 399-0p

Cat. No.: 399-0P

Amount: 100 µg

Price: $110.00

Background

Spinophilin, also known as Neurabin II, is a scaffolding protein enriched in neuronal dendritic spines. It is involved in the targeted loacalization of protein phosphatase-1 (PP1), critical for dopaminergic modulation of glutamate neurotransmission.
More recently it has also been identified as a tumor suppressor. Loss of its function induces a proliferative response by increasing retinoblastoma protein (pRb) phosphorylation.

1 ) Brocos-Mosquera I et al., Prog. Neuropsychopharmacol. Biol. Psychiatry (2018)
2 ) Carnero A et al., Curr. Mol. Med. (2012)
3 ) Barnes AP et al., Brain Res. Mol. Brain Res. (2004)
4 ) Hsieh-Wilson LC et al., J. Biol. Chem. (2003)
5 ) Hsieh-Wilson LC et al., Biochemistry (1999)
6 ) Satoh A et al., J. Biol. Chem. (1998)
7 ) Allen PB et al., Proc. Natl. Acad. Sci. U.S.A. (1997)

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