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Spinophilin - 399 005

A protein enriched at dendritic spines
Polyclonal Guinea pig purified antibody
Cat. No.: 399 005
Amount: 50 µg
Price: 450.00 €
Cat. No. 399 005 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 1000 up to 1 : 5000 gallery  
IHC: 1 : 500 gallery  
IHC-P/FFPE: not tested yet
Immunogen Synthetic peptide corresponding to AA 290 to 302 from rat Spinophilin (UniProt Id: O35274)
Reactivity Reacts with: mouse (Q6R891), rat (O35274).
Other species not tested yet.
Specificity Specific for Spinophilin isoform1. Does not detect isoform 2.
Matching control protein/peptide 399-0P
Data sheet 399_005.pdf
Cat. No.: 399 005
Quantity: 50 µg
Price: 450.00 €
Background
Spinophilin, also known as Neurabin II, is a scaffolding protein enriched in neuronal dendritic spines. It is involved in the targeted loacalization of protein phosphatase-1 (PP1), critical for dopaminergic modulation of glutamate neurotransmission.
More recently it has also been identified as a tumor suppressor. Loss of its function induces a proliferative response by increasing retinoblastoma protein (pRb) phosphorylation.