Cat. No.: 198 103
Amount: 50 µg
Price:
$455.00
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| Cat. No. 198 103 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Recombinant protein corresponding to AA 3 to 96 from mouse GAD2 (UniProt Id: P48320) |
| Reactivity |
Reacts with: rat (P18088), mouse (P48318). Other species not tested yet. |
| Specificity | Specific for GAD 2 / GAD 65. |
| Matching control protein/peptide | 198-1P |
| Remarks |
ELISA: Suitable as detector antibody for sandwich-ELISA with cat. no. 198 111 as capture antibody. The ELISA-protocol for membrane proteins is recommended. |
| Data sheet | 198_103.pdf |
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The glutamic acid decarboxylases GAD 2, also referred to as GAD 65, and GAD 1 / GAD 67 synthesize γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system. The hydrophilic GAD 1 can heterodimerize with the membrane achored GAD 2 and part of GAD 1 is targeted to inhibitory nerve terminals by this mechanisms. Although both proteins exhibit significant differences in their N-terminus they share high homology in the rest of the molecule.
GADs are a widely used markers for the GABAergic system. In type 1 diabetes GAD 1 has been identified as a major autoantigen.