Cat. No.: 227 003
Amount: 50 µg
Price:
$375.00
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| Cat. No. 227 003 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Recombinant protein corresponding to AA 5 to 105 from mouse BNIP1 (UniProt Id: Q6QD59) |
| Reactivity |
Reacts with: rat (Q8VHI8), mouse (Q6QD59). Other species not tested yet. |
| Specificity | Specific for BNIP 1, antigen present in all 4 splice variants. |
| Data sheet | 227_003.pdf |
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BNIPs belong to the proapoptotic BH3-only protein family. Three isoforms have been described so far. BNIP 1 is involved in the maintenance of ER-integrity. It is a member of the syntaxin 18 complex which is involved in membrane trafficking between the ER and Golgi. Four different BNIP 1 splice variants have been described so far, one of which contains a highly conserved BH3 domain. All BNIP 1 variants are able to interact with the apoptosis regulators BCL2 and BCL2L1.