|Cat. No. 474-0P||
100 µg protein, lyophilized. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Control proteins should be stored at +4°C when still lyophilized. Do not freeze!
|Immunogen||Recombinant protein corresponding to residues near the carboxy terminus of mouse Tight junction protein ZO-1. (UniProt Id: P39447)|
|Matching antibodies||474 005|
ZO-1 (also known as TJP1) is a peripheral membrane phosphoprotein with a molecular mass of 220 kDa, located on the cytoplasmic face and is expressed in tight junctions of both epithelial and endothelial cells. (1) Two isoforms, ZO-1α− and ZO-1α+, have been described, which, as a result of alternative RNA splicing, differ by an internal 80 amino acid sequence. (2)
ZO-1 binds the transmembrane proteins occludin and the claudins linking them to cytoskeletal actin. (3)