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TECPR 1 antibody - 458 003

TECPR1 is a tethering factor involved in autophagy
Polyclonal rabbit purified antibody
Cat. No.: 458 003
Amount: 50 µg
Price: $370.00
Cat. No. 458 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: yes (AP-staining) (see remarks) gallery  
IP: not tested yet
ICC: not tested yet
IHC: not tested yet
IHC-P/FFPE: not tested yet
Immunogen Synthetic peptide corresponding to AA 1115 to 1134 from rat Tecpr1 (UniProt Id: Q3ZBA0)
Reactivity Reacts with: rat (Q3ZBA0).
Other species not tested yet.
Specificity Specific for TECPR1
Matching control protein/peptide 458-0P
Remarks

WB: Detects endogenous levels of TECPR1 in brain samples.

Data sheet 458_003.pdf
Cat. No.: 458 003
Quantity: 50 µg
Price: $370.00
Background

Tectonin beta-propeller repeat-containing protein 1 (TECPR1) consists of two WD-repeat domains (TR), two dysferlin domains, an unstructured region and a PH domain (1). It is involved in autophagy by promoting autophagosome fusion with lysosomes (2) by associating with the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns3P) present at the surface of autophagosomes (3). TECPR1 has also been shown to participate in selective autophagy against bacterial pathogens (4) and aggrephagy of protein aggregats that accompany neurodegenarative diseases (5).