|Cat. No. 458 003||50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.|
WB: yes (AP-staining) (see remarks) gallery
IP: not tested yet
ICC: not tested yet
IHC: not tested yet
IHC-P/FFPE: not tested yet
|Immunogen||Synthetic peptide corresponding to AA 1115 to 1134 from rat Tecpr1 (UniProt Id: Q3ZBA0)|
Reacts with: rat (Q3ZBA0).
Other species not tested yet.
|Specificity||Specific for TECPR1|
|Matching control protein/peptide||458-0P|
WB: Detects endogenous levels of TECPR1 in brain samples.
Tectonin beta-propeller repeat-containing protein 1 (TECPR1) consists of two WD-repeat domains (TR), two dysferlin domains, an unstructured region and a PH domain (1). It is involved in autophagy by promoting autophagosome fusion with lysosomes (2) by associating with the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns3P) present at the surface of autophagosomes (3). TECPR1 has also been shown to participate in selective autophagy against bacterial pathogens (4) and aggrephagy of protein aggregats that accompany neurodegenarative diseases (5).