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Cannabinoid receptor CB1-R antibody - 258 003

CB1-R is a G-protein coupled receptor responsive to cannabinoids
Polyclonal rabbit purified antibody
Cat. No.: 258 003
Amount: 50 µg
Price: $370.00
Cat. No. 258 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 (see remarks) gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P/FFPE: 1 : 500 gallery  
Immunogen Synthetic peptide corresponding to AA 450 to 473 from rat CB1-R (UniProt Id: P20272)
Reactivity Reacts with: rat (P20272), mouse (P47746).
Other species not tested yet.
Specificity Specific for CB1-R. K.O. PubMed: 32631938
Remarks

WB: Non-boiled samples are recommended.

Data sheet 258_003.pdf

References for Cannabinoid receptor CB1-R - 258 003

An opposing function of paralogs in balancing developmental synapse maturation.
Favaro PD, Huang X, Hosang L, Stodieck S, Cui L, Liu YZ, Engelhardt KA, Schmitz F, Dong Y, Löwel S, Schlüter OM, et al.
PLoS biology (2018) 1612: e2006838. 258 003 WB; tested species: mouse
Involvement of the endocannabinoid system in the physiological response to transient common carotid artery occlusion and reperfusion.
Quartu M, Poddighe L, Melis T, Serra MP, Boi M, Lisai S, Carta G, Murru E, Muredda L, Collu M, Banni S, et al.
Lipids in health and disease (2017) 161: 14. 258 003 WB, IHC
Subventricular zone neural progenitors reverse TNF-alpha effects in cortical neurons.
Morini R, Ghirardini E, Butti E, Verderio C, Martino G, Matteoli M
Stem cell research & therapy (2015) 6: 166. 258 003 ICC
Developmentally transient CB1Rs on cerebellar afferents suppress afferent input, downstream synaptic excitation, and signaling to migrating neurons.
Barnes JL, Mohr C, Ritchey CR, Erikson CM, Shiina H, Rossi DJ
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 258 003 IHC; KO verified; tested species: mouse,rat
A High-Resolution Method for Quantitative Molecular Analysis of Functionally Characterized Individual Synapses.
Holderith N, Heredi J, Kis V, Nusser Z
Cell reports (2020) 324: 107968. 258 003 IHC; tested species: rat
Phenotypic characterization of MCP-1 expressing neurons in the rat cerebral cortex.
Mulet M, Blasco-Ibáñez JM, Kirstein M, Crespo C, Nacher J, Varea E
Journal of chemical neuroanatomy (2020) 106: 101785. 258 003 IHC; tested species: rat
Dark exposure affects plasticity-related molecules and interneurons throughout the visual system during adulthood.
Carceller H, Guirado R, Nacher J
The Journal of comparative neurology (2019) : . 258 003 IHC; tested species: mouse
Active zone proteins RIM1αβ are required for normal corticostriatal transmission and action control.
Kupferschmidt DA, Augustin SM, Johnson KA, Lovinger DM
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) : . 258 003 IHC; tested species: mouse
NPAS4 recruits CCK basket cell synapses and enhances cannabinoid-sensitive inhibition in the mouse hippocampus.
Hartzell AL, Martyniuk KM, Brigidi GS, Heinz DA, Djaja NA, Payne A, Bloodgood BL
eLife (2018) 7: . 258 003 IHC; tested species: mouse
Involvement of the endocannabinoid system in the physiological response to transient common carotid artery occlusion and reperfusion.
Quartu M, Poddighe L, Melis T, Serra MP, Boi M, Lisai S, Carta G, Murru E, Muredda L, Collu M, Banni S, et al.
Lipids in health and disease (2017) 161: 14. 258 003 WB, IHC
Differential role of GABAA receptors and neuroligin 2 for perisomatic GABAergic synapse formation in the hippocampus.
Panzanelli P, Früh S, Fritschy JM
Brain structure & function (2017) 2229: 4149-4161. 258 003 IHC; tested species: mouse
Neuronal Dystroglycan Is Necessary for Formation and Maintenance of Functional CCK-Positive Basket Cell Terminals on Pyramidal Cells.
Früh S, Romanos J, Panzanelli P, Bürgisser D, Tyagarajan SK, Campbell KP, Santello M, Fritschy JM
The Journal of neuroscience : the official journal of the Society for Neuroscience (2016) 3640: 10296-10313. 258 003 IHC; tested species: mouse
Cat. No.: 258 003
Quantity: 50 µg
Price: $370.00
An opposing function of paralogs in balancing developmental synapse maturation.
Favaro PD, Huang X, Hosang L, Stodieck S, Cui L, Liu YZ, Engelhardt KA, Schmitz F, Dong Y, Löwel S, Schlüter OM, et al.
PLoS biology (2018) 1612: e2006838. 258 003 WB; tested species: mouse
Involvement of the endocannabinoid system in the physiological response to transient common carotid artery occlusion and reperfusion.
Quartu M, Poddighe L, Melis T, Serra MP, Boi M, Lisai S, Carta G, Murru E, Muredda L, Collu M, Banni S, et al.
Lipids in health and disease (2017) 161: 14. 258 003 WB, IHC
Subventricular zone neural progenitors reverse TNF-alpha effects in cortical neurons.
Morini R, Ghirardini E, Butti E, Verderio C, Martino G, Matteoli M
Stem cell research & therapy (2015) 6: 166. 258 003 ICC
Developmentally transient CB1Rs on cerebellar afferents suppress afferent input, downstream synaptic excitation, and signaling to migrating neurons.
Barnes JL, Mohr C, Ritchey CR, Erikson CM, Shiina H, Rossi DJ
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 258 003 IHC; KO verified; tested species: mouse,rat
A High-Resolution Method for Quantitative Molecular Analysis of Functionally Characterized Individual Synapses.
Holderith N, Heredi J, Kis V, Nusser Z
Cell reports (2020) 324: 107968. 258 003 IHC; tested species: rat
Phenotypic characterization of MCP-1 expressing neurons in the rat cerebral cortex.
Mulet M, Blasco-Ibáñez JM, Kirstein M, Crespo C, Nacher J, Varea E
Journal of chemical neuroanatomy (2020) 106: 101785. 258 003 IHC; tested species: rat
Dark exposure affects plasticity-related molecules and interneurons throughout the visual system during adulthood.
Carceller H, Guirado R, Nacher J
The Journal of comparative neurology (2019) : . 258 003 IHC; tested species: mouse
Active zone proteins RIM1αβ are required for normal corticostriatal transmission and action control.
Kupferschmidt DA, Augustin SM, Johnson KA, Lovinger DM
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) : . 258 003 IHC; tested species: mouse
NPAS4 recruits CCK basket cell synapses and enhances cannabinoid-sensitive inhibition in the mouse hippocampus.
Hartzell AL, Martyniuk KM, Brigidi GS, Heinz DA, Djaja NA, Payne A, Bloodgood BL
eLife (2018) 7: . 258 003 IHC; tested species: mouse
Involvement of the endocannabinoid system in the physiological response to transient common carotid artery occlusion and reperfusion.
Quartu M, Poddighe L, Melis T, Serra MP, Boi M, Lisai S, Carta G, Murru E, Muredda L, Collu M, Banni S, et al.
Lipids in health and disease (2017) 161: 14. 258 003 WB, IHC
Differential role of GABAA receptors and neuroligin 2 for perisomatic GABAergic synapse formation in the hippocampus.
Panzanelli P, Früh S, Fritschy JM
Brain structure & function (2017) 2229: 4149-4161. 258 003 IHC; tested species: mouse
Neuronal Dystroglycan Is Necessary for Formation and Maintenance of Functional CCK-Positive Basket Cell Terminals on Pyramidal Cells.
Früh S, Romanos J, Panzanelli P, Bürgisser D, Tyagarajan SK, Campbell KP, Santello M, Fritschy JM
The Journal of neuroscience : the official journal of the Society for Neuroscience (2016) 3640: 10296-10313. 258 003 IHC; tested species: mouse
Background
The cannabinoid receptor CB1-R is a G-protein coupled receptor (GPCR) with 7 transmembrane domains. It is responsive to tetrahydrocannabinol, the psychotropic component of marijuana.
Endogenous cannabinoids (endocannabinoids) are released from postsynaptic neurons and act onto presynaptic cannabinoid receptors where they play important physiological roles in synaptic plasticity, analgesia, appetite, and neuroprotection.