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Cannabinoid receptor CB1-R - 258 008

A G-protein coupled receptor responsive to cannabinoids
Monoclonal Recombinant rabbit purified IgG
Cat. No.: 258 008
Amount: 50 µg
Price: 415.00 €
Cat. No. 258 008 50 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: not tested yet
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P/FFPE: 1 : 1000 gallery  
Clone Rb289C1
Subtype IgG1 (κ light chain)
Immunogen Synthetic peptide corresponding to AA 450 to 473 from rat CB1-R (UniProt Id: P20272)
Reactivity Reacts with: rat (P20272), mouse (P47746), human (P21554).
Other species not tested yet.
Specificity Specific for CB1-R. K.O.
Remarks

This antibody is a chimeric antibody based on the monoclonal mouse antibody clone 289C1. The constant regions of the heavy and light chains have been replaced by rabbit specific sequences. Therefore, the antibody can be used with standard anti-rabbit secondary reagents. The antibody has been expressed in mammalian cells.

Data sheet 258_008.pdf
Cat. No.: 258 008
Quantity: 50 µg
Price: 415.00 €
Background
The cannabinoid receptor CB1-R is a G-protein coupled receptor (GPCR) with 7 transmembrane domains. It is responsive to tetrahydrocannabinol, the psychotropic component of marijuana.
Endogenous cannabinoids (endocannabinoids) are released from postsynaptic neurons and act onto presynaptic cannabinoid receptors where they play important physiological roles in synaptic plasticity, analgesia, appetite, and neuroprotection.