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beta3-Integrin - 240 303

Cell adhesion molecules
Polyclonal rabbit purified antibody
Cat. No.: 240 303
Amount: 50 µg
Price: $370.00
Cat. No. 240 303 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 gallery  
IP: not tested yet
ICC: not tested yet
IHC: not tested yet
IHC-P/FFPE: not tested yet
Immunogen Synthetic peptide corresponding to AA 76 to 91 from mouse β3-Integrin (UniProt Id: O54890)
Reactivity Reacts with: rat (Q8R2H2), mouse (O54890).
Other species not tested yet.
Specificity Specific for β3-integrin.
Matching control protein/peptide 240-3P
Data sheet 240_303.pdf
Cat. No.: 240 303
Quantity: 50 µg
Price: $370.00
Background
Integrins are heterodimers consisting of noncovalently associated α and β subunits. More than 20 different integrin receptors composed of 16 different α and 8 different β subunits have been described so far. Most of these receptors bind components of the extracellular matrix like fibronectin, collagen and vitronectin.
Integrins are transmembrane glycoproteins involved in many normal cellular processes (embryogenesis, hemostasis, tissue repair, immune response) but also in abnormal pathological events like metastatic spread of tumor cells. In humans five isoforms of β1-integrin have been described (β1A-1D, 1C-2). β1-integrin is also known as very late antigen VLA or CD29.
β3-integrin, also referred to a CD 61, is found with the alpha IIb chain in platelets.