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beta3-Integrin - 240-3P

Cell adhesion molecules
control peptide
Cat. No.: 240-3P
Amount: 100 µg
Price: $90.00
Cat. No. 240-3P 100 µg peptide, lyophilized. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Control peptides should be stored at -20°C when still lyophilized!
Immunogen Synthetic peptide corresponding to AA 76 to 91 from mouse β3-Integrin (UniProt Id: O54890)
Recommended dilution Optimal concentrations should be determined by the end-user.
Matching antibodies 240 303
Remarks

This control peptide consists of the synthetic peptide (aa 76 - 91 of mouse β3-integrin) that has been used for immunization. It has been tested in preadsorption experiments and blocks efficiently and specifically the corresponding signal in Western blots. The amount of peptide needed for efficient blocking depends on the titer and on the affinity of the antibody to the antigen.

Data sheet 240-3p.pdf
Cat. No.: 240-3P
Quantity: 100 µg
Price: $90.00
Background
Integrins are heterodimers consisting of noncovalently associated α and β subunits. More than 20 different integrin receptors composed of 16 different α and 8 different β subunits have been described so far. Most of these receptors bind components of the extracellular matrix like fibronectin, collagen and vitronectin.
Integrins are transmembrane glycoproteins involved in many normal cellular processes (embryogenesis, hemostasis, tissue repair, immune response) but also in abnormal pathological events like metastatic spread of tumor cells. In humans five isoforms of β1-integrin have been described (β1A-1D, 1C-2). β1-integrin is also known as very late antigen VLA or CD29.
β3-integrin, also referred to a CD 61, is found with the alpha IIb chain in platelets.
Protocols