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Caspase 3 - 236 003

A key regulator of apoptosis
Polyclonal rabbit purified antibody
Cat. No.: 236 003
Amount: 50 µg
Price: 370.00 €
Cat. No. 236 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: not tested yet
IP: not tested yet
ICC: 1 : 500 up to 1 : 1000 gallery  
IHC: not tested yet
IHC-P/FFPE: not tested yet
Immunogen Synthetic peptide corresponding to AA 170 to 175 from mouse Caspase3 (UniProt Id: P70677)
Reactivity Reacts with: human (P42574), rat (P55213), mouse (P70677), cow.
Other species not tested yet.
Specificity Recognizes cleaved and activated caspase 3.
Data sheet 236_003.pdf
Cat. No.: 236 003
Quantity: 50 µg
Price: 370.00 €
Background
Cell proliferation, differentiation and apoptosis are central features of tissue homeostasis. Inhibition of apoptosis might be involved in the pathogenesis of cancer by extending cell life and growth.
The activation of caspases, particularly caspase 3, appears to be a central part in most apoptotic pathways. The inactive caspase 3 protoenzyme is activated by proteolytic cleavage behind aspartic acid at position 175 leading to activated p17 and p12 fragments. In its active form caspase 3 cleaves many key proteins like the nuclear enzyme poly (ADPribose) polymerase (PARP).
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