Cat. No.: 226 108
Amount: 50 µg
Price:
$415.00
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| Cat. No. 226 108 |
50 µg purified recombinant IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Clone | Hu108B5 |
| Subtype | IgG1 (κ light chain) |
| Immunogen | Synthetic peptide corresponding to residues near the amino terminus of rat c-Fos (UniProt Id: P12841) |
| Reactivity |
Reacts with: mouse (P01101), rat (P12841), human (P01100). Other species not tested yet. |
| Matching control protein/peptide | 226-0P |
| Remarks |
This antibody is a chimeric antibody based on the monoclonal rat antibody 108B5. The constant regions of the heavy and light chains have been replaced with human specific sequences. Therefore, the antibody can be used with standard anti-human secondary reagents. The antibody has been expressed in mammalian cells. |
| Data sheet | 226_108.pdf |
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The Fos gene family consists of 4 members: c-Fos, FosB, FosL1, and FosL2, also called Fos related antigen 1 and 2 (FRA1 and 2). These leucine zipper proteins can dimerize with proteins of the Jun family leading to the formation of the transcription factor complex AP1 (1).
The expression of Fos proteins is rapidly and transiently induced by different extracellular stimuli such as growth factors, cytokines, neurotransmitters, polypeptide hormones and stress (2).
In addition Fos proteins can be phosphorylated by ERK kinases modulating transcriptional activity, protein stability and localization (3). c-Fos is the homologue to the Finkel-Biskis-Jinkins (FBJ) murine osteosarcoma virus oncogene (4).