Cat. No.: 214 011BT
Amount: 100 µg
Price:
$465.00
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| Cat. No. 214 011BT |
100 µg purified IgG, lyophilized, labeled with Biotin.
Biotin is a small vitamin B complex molecule. Its small size minimizes interference with antibody binding sites and allows for efficient conjugation without compromising antibody functionality. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications |
IP: yes ICC: not tested yet IHC: 1 : 500 gallery IHC-P: not tested yet |
| Label | biotin |
| Clone | 351C10 |
| Subtype | IgG1 (κ light chain) |
| Immunogen | Full-length recombinant human Calbindin D28k protein (UniProt Id: P05937) |
| Reactivity |
Reacts with: human (P05937), rat (P07171), mouse (P12658), zebrafish. Other species not tested yet. |
| Matching control protein/peptide | 214-0P |
| Data sheet | 214_011bt.pdf |
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Two isoforms of the vitamin D-dependent Ca-binding proteins have been described so far: calbindin D28k, also referred to as CALB 1, D-28k, and CAB 27, and calbindin D29k, also known as calretinin. These proteins are expressed in cells that have to handle a high calcium influx such as brain, bone, teeth, inner ear and others. Calbindins are believed to regulate cellular activity by suppressing or buffering intracellur calcium. In the brain calbindin D28k is a useful marker for specific neuronal cell types. It is particularly concentrated in the dendrites and perikarya of cerebellar Purkinje cells, but is also found in many GABAergic interneurons in the cortex.