|Cat. No. 160 022||200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.|
WB: 1 : 1000 (AP staining) gallery
IP: not tested yet
ICC: 1 : 500 gallery
IHC: not tested yet
IHC-P/FFPE: not tested yet
|Immunogen||Recombinant protein corresponding to AA 152 to 354 from human Homer1b/c (UniProt Id: Q86YM7-1)|
Reacts with: rat (Q9Z214), mouse, human (Q86YM7-1).
Other species not tested yet.
|Specificity||Specific for homer 1b and 1c; no cross-reactivity to homer 1a.|
|Matching control protein/peptide||160-02P|
Homer is a scaffolding protein of the post synaptic density (PSD) and enriched at excitatory synapses. The protein binds metabotropic glutamate receptors, TRPC1, proteins of the Shank family and others. By aggregating these proteins into clusters, homer was suggested to organize distinct signalling domains.
Three isoforms, Homer 1, 2 and 3 have been described. Each of these isoforms is subject to alternative splicing yielding the splice variants a, b, c, d.