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Homer 1b/c - 160-02P

A post synaptic density (PSD) protein involved in the targeting of glutamate receptors
control protein
Cat. No.: 160-02P
Amount: 100 µg
Price: $90.00
Cat. No. 160-02P 100 µg protein, lyophilized. For reconstitution add 100 µl H2O to get a 1mg/ml solution in TBS. Then aliquot and store at -20°C to -80°C until use.
Immunogen Recombinant protein corresponding to AA 152 to 354 from human Homer1b/c (UniProt Id: Q86YM7-1)
Recommended dilution Optimal concentrations should be determined by the end-user.
Matching antibodies 160 022, 160 023
Remarks

This control protein consists of the recombinant protein (aa 152-354 of human homer 1b) that has been used for immunization. It has been tested in preadsorption experiments and blocks efficiently and specifically the corresponding signal in Western blots. The amount of protein needed for efficient blocking depends on the titer and on the affinity of the antibody to the antigen.

Data sheet 160-02p.pdf
Cat. No.: 160-02P
Quantity: 100 µg
Price: $90.00
Background

Homer is a scaffolding protein of the post synaptic density (PSD) and enriched at excitatory synapses. The protein binds metabotropic glutamate receptors, TRPC1, proteins of the Shank family and others. By aggregating these proteins into clusters, homer was suggested to organize distinct signalling domains.
Three isoforms, Homer 1, 2 and 3 have been described. Each of these isoforms is subject to alternative splicing yielding the splice variants a, b, c, d.

Protocols