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Homer1 antibody - 160 006

Homer1 , 2 and 3 are post synaptic density (PSD) proteins involved in the targeting of glutamate receptors
Chicken polyclonal purified antibody
Cat. No.: 160 006
Amount: 50 µg
Price: $410.00
Cat. No. 160 006 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 1000 gallery  
IHC: 1 : 500 gallery  
IHC-P: 1 : 500 gallery  
ExM: 1 : 250 (see remarks) gallery  
Immunogen Recombinant protein corresponding to the N-terminal half of human Homer 1 (UniProt Id: Q86YM7)
Reactivity Reacts with: human (Q86YM7), rat (Q9Z214), mouse (Q9Z2Y3).
Other species not tested yet.
Specificity Specific for Homer 1. According to Soloviev et al. (2000), aa 1 - 180 are present in isoforms a, b, c and d.
Matching control protein/peptide 160-0P
Remarks

ExM: This antibody has been successfully used for the magnified analysis of the proteome (MAP) expansion microscopy method (MAP; Ku et al. 2016. Nature Biotechnology 34:973-981)
Data sheet 160_006.pdf

References for Homer1 - 160 006

Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model.
Aryal S, Bonanno K, Song B, Mani DR, Keshishian H, Carr SA, Sheng M, Dejanovic B
Cell reports (2023) 425: 112497. 160 006 WB; tested species: human
Neuronopathic GBA1L444P Mutation Accelerates Glucosylsphingosine Levels and Formation of Hippocampal Alpha-Synuclein Inclusions.
Mahoney-Crane CL, Viswanathan M, Russell D, Curtiss RAC, Freire J, Bobba SS, Coyle SD, Kandebo M, Yao L, Wan BL, Hatcher NG, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2023) 433: 501-521. 160 006 WB; tested species: mouse
Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus.
Lloyd BA, Han Y, Roth R, Zhang B, Aoto J
Nature communications (2023) 141: 4706. 160 006 ICC; tested species: mouse
Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models.
Rueda-Carrasco J, Sokolova D, Lee SE, Childs T, Jurčáková N, Crowley G, De Schepper S, Ge JZ, Lachica JI, Toomey CE, Freeman OJ, et al.
The EMBO journal (2023) 4219: e113246. 160 006 ICC; tested species: rat
High-Content Screening of Synaptic Density Modulators in Primary Neuronal Cultures.
Coulon A, Siedlecki-Wullich D, Najdek C, Gelle C, Ayral AM, Demiautte F, Lambert E, Vandeputte A, Brodin P, Mendes T, Lambert JC, et al.
Current protocols (2023) 310: e904. 160 006 ICC; tested species: rat
Cationic peptides erase memories by removing synaptic AMPA receptors through endophilin-mediated endocytosis.
Beier K, Stokes E, Zhuang Y, Toledano M, Vasquez J, Azouz G, Hui M, Tyler I, Shi X, Aoto J
Research square (2023) : . 160 006 ICC, ExM; tested species: mouse
A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer's disease.
Jones ME, Büchler J, Dufor T, Palomer E, Teo S, Martin-Flores N, Boroviak K, Metzakopian E, Gibb A, Salinas PC
Science advances (2023) 92: eabo7421. 160 006 ICC, IHC; tested species: mouse
Interleukin-4 receptor signaling modulates neuronal network activity.
Hanuscheck N, Thalman C, Domingues M, Schmaul S, Muthuraman M, Hetsch F, Ecker M, Endle H, Oshaghi M, Martino G, Kuhlmann T, et al.
The Journal of experimental medicine (2022) 2196: . 160 006 ICC, IHC; tested species: human,mouse
Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein.
Brzozowski CF, Hijaz BA, Singh V, Gcwensa NZ, Kelly K, Boyden ES, West AB, Sarkar D, Volpicelli-Daley LA
Acta neuropathologica communications (2021) 91: 180. 160 006 ICC, IHC, ExM; tested species: mouse
Pyk2 overexpression in postsynaptic neurons blocks amyloid β1-42-induced synaptotoxicity in microfluidic co-cultures.
Kilinc D, Vreulx AC, Mendes T, Flaig A, Marques-Coelho D, Verschoore M, Demiautte F, Amouyel P,  , Eysert F, Dourlen P, et al.
Brain communications (2020) 22: fcaa139. 160 006 ICC; tested species: rat
Excitatory synaptic structural abnormalities produced by templated aggregation of α-syn in the basolateral amygdala.
Gcwensa NZ, Russell DL, Long KY, Brzozowski CF, Liu X, Gamble KL, Cowell RM, Volpicelli-Daley LA
Neurobiology of disease (2024) 199: 106595. 160 006 IHC; tested species: mouse
Age-related dysregulation of homeostatic control in neuronal microcircuits.
Radulescu CI, Doostdar N, Zabouri N, Melgosa-Ecenarro L, Wang X, Sadeh S, Pavlidi P, Airey J, Kopanitsa M, Clopath C, Barnes SJ, et al.
Nature neuroscience (2023) 2612: 2158-2170. 160 006 IHC; tested species: mouse
Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain.
Singh V, Menard MA, Serrano GE, Beach TG, Zhao HT, Riley-DiPaolo A, Subrahmanian N, LaVoie MJ, Volpicelli-Daley LA
Acta neuropathologica communications (2023) 111: 201. 160 006 IHC; tested species: human,mouse
A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer's disease.
Jones ME, Büchler J, Dufor T, Palomer E, Teo S, Martin-Flores N, Boroviak K, Metzakopian E, Gibb A, Salinas PC
Science advances (2023) 92: eabo7421. 160 006 ICC, IHC; tested species: mouse
Development and cadherin-mediated control of prefrontal corticostriatal projections in mice.
Mesías RE, Zaki Y, Guevara CA, Friedman LG, Hussein A, Therrien K, Magee AR, Tzavaras N, Del Valle P, Baxter MG, Huntley GW, et al.
iScience (2023) 2610: 108002. 160 006 IHC; tested species: mouse
Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis.
Mein N, von Stackelberg N, Wickel J, Geis C, Chung HY
Journal of neuroinflammation (2023) 201: 289. 160 006 IHC; tested species: mouse
Influenza vaccine is able to prevent neuroinflammation triggered by H7N7 IAV infection.
Demuth L, Ohm M, Michaelsen-Preusse K, Schulze K, Riese P, Guzmán CA, Korte M, Hosseini S
Frontiers in pharmacology (2023) 14: 1142639. 160 006 IHC; tested species: mouse
URMC-099 prophylaxis prevents hippocampal vascular vulnerability and synaptic damage in an orthopedic model of delirium superimposed on dementia.
Miller-Rhodes P, Li H, Velagapudi R, Chiang W, Terrando N, Gelbard HA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2022) 366: e22343. 160 006 IHC; tested species: mouse
Interleukin-4 receptor signaling modulates neuronal network activity.
Hanuscheck N, Thalman C, Domingues M, Schmaul S, Muthuraman M, Hetsch F, Ecker M, Endle H, Oshaghi M, Martino G, Kuhlmann T, et al.
The Journal of experimental medicine (2022) 2196: . 160 006 ICC, IHC; tested species: human,mouse
Pregabalin improves axon regeneration and motor outcome in a rodent stroke model.
Kugler C, Blank N, Matuskova H, Thielscher C, Reichenbach N, Lin TC, Bradke F, Petzold GC
Brain communications (2022) 44: fcac170. 160 006 IHC; tested species: mouse
Circulating Pro-Inflammatory Exosomes Worsen Stroke Outcomes in Aging.
Zhang H, Lin S, McElroy CL, Wang B, Jin D, Uteshev VV, Jin K
Circulation research (2021) 1297: e121-e140. 160 006 IHC; tested species: rat
Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein.
Brzozowski CF, Hijaz BA, Singh V, Gcwensa NZ, Kelly K, Boyden ES, West AB, Sarkar D, Volpicelli-Daley LA
Acta neuropathologica communications (2021) 91: 180. 160 006 ICC, IHC, ExM; tested species: mouse
Gabapentinoid treatment promotes corticospinal plasticity and regeneration following murine spinal cord injury.
Sun W, Larson MJ, Kiyoshi CM, Annett AJ, Stalker WA, Peng J, Tedeschi A
The Journal of clinical investigation (2020) 1301: 345-358. 160 006 IHC; tested species: mouse
Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations.
Xu ZX, Kim GH, Tan JW, Riso AE, Sun Y, Xu EY, Liao GY, Xu H, Lee SH, Do NY, Lee CH, et al.
Nature communications (2020) 111: 1797. 160 006 IHC; tested species: mouse
Microglia monitor and protect neuronal function through specialized somatic purinergic junctions.
Cserép C, Pósfai B, Lénárt N, Fekete R, László ZI, Lele Z, Orsolits B, Molnár G, Heindl S, Schwarcz AD, Ujvári K, et al.
Science (New York, N.Y.) (2020) 3676477: 528-537. 160 006 IHC; tested species: mouse
Short-chain fatty acids improve post-stroke recovery via immunological mechanisms.
Sadler R, Cramer JV, Heindl S, Kostidis S, Betz D, Zuurbier KR, Northoff BH, Heijink M, Goldberg MP, Plautz EJ, Roth S, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 160 006 IHC; tested species: mouse
Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation.
Jafari M, Schumacher AM, Snaidero N, Ullrich Gavilanes EM, Neziraj T, Kocsis-Jutka V, Engels D, Jürgens T, Wagner I, Weidinger JDF, Schmidt SS, et al.
Nature neuroscience (2021) 243: 355-367. 160 006 IHC-P; tested species: mouse
P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer's disease model.
Reichenbach N, Delekate A, Breithausen B, Keppler K, Poll S, Schulte T, Peter J, Plescher M, Hansen JN, Blank N, Keller A, et al.
The Journal of experimental medicine (2018) : . 160 006 IHC-P; tested species: mouse
Protecting RNA quality for spatial transcriptomics while improving immunofluorescent staining quality.
Hahn N, Bens M, Kempfer M, Reißig C, Schmidl L, Geis C
Frontiers in neuroscience (2023) 17: 1198154. 160 006 IHC-Fr; tested species: mouse
Cationic peptides erase memories by removing synaptic AMPA receptors through endophilin-mediated endocytosis.
Beier K, Stokes E, Zhuang Y, Toledano M, Vasquez J, Azouz G, Hui M, Tyler I, Shi X, Aoto J
Research square (2023) : . 160 006 ICC, ExM; tested species: mouse
Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein.
Brzozowski CF, Hijaz BA, Singh V, Gcwensa NZ, Kelly K, Boyden ES, West AB, Sarkar D, Volpicelli-Daley LA
Acta neuropathologica communications (2021) 91: 180. 160 006 ICC, IHC, ExM; tested species: mouse
Cat. No.: 160 006
Amount: 50 µg
Price: $410.00
Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model.
Aryal S, Bonanno K, Song B, Mani DR, Keshishian H, Carr SA, Sheng M, Dejanovic B
Cell reports (2023) 425: 112497. 160 006 WB; tested species: human
Neuronopathic GBA1L444P Mutation Accelerates Glucosylsphingosine Levels and Formation of Hippocampal Alpha-Synuclein Inclusions.
Mahoney-Crane CL, Viswanathan M, Russell D, Curtiss RAC, Freire J, Bobba SS, Coyle SD, Kandebo M, Yao L, Wan BL, Hatcher NG, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2023) 433: 501-521. 160 006 WB; tested species: mouse
Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus.
Lloyd BA, Han Y, Roth R, Zhang B, Aoto J
Nature communications (2023) 141: 4706. 160 006 ICC; tested species: mouse
Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models.
Rueda-Carrasco J, Sokolova D, Lee SE, Childs T, Jurčáková N, Crowley G, De Schepper S, Ge JZ, Lachica JI, Toomey CE, Freeman OJ, et al.
The EMBO journal (2023) 4219: e113246. 160 006 ICC; tested species: rat
High-Content Screening of Synaptic Density Modulators in Primary Neuronal Cultures.
Coulon A, Siedlecki-Wullich D, Najdek C, Gelle C, Ayral AM, Demiautte F, Lambert E, Vandeputte A, Brodin P, Mendes T, Lambert JC, et al.
Current protocols (2023) 310: e904. 160 006 ICC; tested species: rat
Cationic peptides erase memories by removing synaptic AMPA receptors through endophilin-mediated endocytosis.
Beier K, Stokes E, Zhuang Y, Toledano M, Vasquez J, Azouz G, Hui M, Tyler I, Shi X, Aoto J
Research square (2023) : . 160 006 ICC, ExM; tested species: mouse
A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer's disease.
Jones ME, Büchler J, Dufor T, Palomer E, Teo S, Martin-Flores N, Boroviak K, Metzakopian E, Gibb A, Salinas PC
Science advances (2023) 92: eabo7421. 160 006 ICC, IHC; tested species: mouse
Interleukin-4 receptor signaling modulates neuronal network activity.
Hanuscheck N, Thalman C, Domingues M, Schmaul S, Muthuraman M, Hetsch F, Ecker M, Endle H, Oshaghi M, Martino G, Kuhlmann T, et al.
The Journal of experimental medicine (2022) 2196: . 160 006 ICC, IHC; tested species: human,mouse
Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein.
Brzozowski CF, Hijaz BA, Singh V, Gcwensa NZ, Kelly K, Boyden ES, West AB, Sarkar D, Volpicelli-Daley LA
Acta neuropathologica communications (2021) 91: 180. 160 006 ICC, IHC, ExM; tested species: mouse
Pyk2 overexpression in postsynaptic neurons blocks amyloid β1-42-induced synaptotoxicity in microfluidic co-cultures.
Kilinc D, Vreulx AC, Mendes T, Flaig A, Marques-Coelho D, Verschoore M, Demiautte F, Amouyel P,  , Eysert F, Dourlen P, et al.
Brain communications (2020) 22: fcaa139. 160 006 ICC; tested species: rat
Excitatory synaptic structural abnormalities produced by templated aggregation of α-syn in the basolateral amygdala.
Gcwensa NZ, Russell DL, Long KY, Brzozowski CF, Liu X, Gamble KL, Cowell RM, Volpicelli-Daley LA
Neurobiology of disease (2024) 199: 106595. 160 006 IHC; tested species: mouse
Age-related dysregulation of homeostatic control in neuronal microcircuits.
Radulescu CI, Doostdar N, Zabouri N, Melgosa-Ecenarro L, Wang X, Sadeh S, Pavlidi P, Airey J, Kopanitsa M, Clopath C, Barnes SJ, et al.
Nature neuroscience (2023) 2612: 2158-2170. 160 006 IHC; tested species: mouse
Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain.
Singh V, Menard MA, Serrano GE, Beach TG, Zhao HT, Riley-DiPaolo A, Subrahmanian N, LaVoie MJ, Volpicelli-Daley LA
Acta neuropathologica communications (2023) 111: 201. 160 006 IHC; tested species: human,mouse
A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer's disease.
Jones ME, Büchler J, Dufor T, Palomer E, Teo S, Martin-Flores N, Boroviak K, Metzakopian E, Gibb A, Salinas PC
Science advances (2023) 92: eabo7421. 160 006 ICC, IHC; tested species: mouse
Development and cadherin-mediated control of prefrontal corticostriatal projections in mice.
Mesías RE, Zaki Y, Guevara CA, Friedman LG, Hussein A, Therrien K, Magee AR, Tzavaras N, Del Valle P, Baxter MG, Huntley GW, et al.
iScience (2023) 2610: 108002. 160 006 IHC; tested species: mouse
Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis.
Mein N, von Stackelberg N, Wickel J, Geis C, Chung HY
Journal of neuroinflammation (2023) 201: 289. 160 006 IHC; tested species: mouse
Influenza vaccine is able to prevent neuroinflammation triggered by H7N7 IAV infection.
Demuth L, Ohm M, Michaelsen-Preusse K, Schulze K, Riese P, Guzmán CA, Korte M, Hosseini S
Frontiers in pharmacology (2023) 14: 1142639. 160 006 IHC; tested species: mouse
URMC-099 prophylaxis prevents hippocampal vascular vulnerability and synaptic damage in an orthopedic model of delirium superimposed on dementia.
Miller-Rhodes P, Li H, Velagapudi R, Chiang W, Terrando N, Gelbard HA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2022) 366: e22343. 160 006 IHC; tested species: mouse
Interleukin-4 receptor signaling modulates neuronal network activity.
Hanuscheck N, Thalman C, Domingues M, Schmaul S, Muthuraman M, Hetsch F, Ecker M, Endle H, Oshaghi M, Martino G, Kuhlmann T, et al.
The Journal of experimental medicine (2022) 2196: . 160 006 ICC, IHC; tested species: human,mouse
Pregabalin improves axon regeneration and motor outcome in a rodent stroke model.
Kugler C, Blank N, Matuskova H, Thielscher C, Reichenbach N, Lin TC, Bradke F, Petzold GC
Brain communications (2022) 44: fcac170. 160 006 IHC; tested species: mouse
Circulating Pro-Inflammatory Exosomes Worsen Stroke Outcomes in Aging.
Zhang H, Lin S, McElroy CL, Wang B, Jin D, Uteshev VV, Jin K
Circulation research (2021) 1297: e121-e140. 160 006 IHC; tested species: rat
Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein.
Brzozowski CF, Hijaz BA, Singh V, Gcwensa NZ, Kelly K, Boyden ES, West AB, Sarkar D, Volpicelli-Daley LA
Acta neuropathologica communications (2021) 91: 180. 160 006 ICC, IHC, ExM; tested species: mouse
Gabapentinoid treatment promotes corticospinal plasticity and regeneration following murine spinal cord injury.
Sun W, Larson MJ, Kiyoshi CM, Annett AJ, Stalker WA, Peng J, Tedeschi A
The Journal of clinical investigation (2020) 1301: 345-358. 160 006 IHC; tested species: mouse
Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations.
Xu ZX, Kim GH, Tan JW, Riso AE, Sun Y, Xu EY, Liao GY, Xu H, Lee SH, Do NY, Lee CH, et al.
Nature communications (2020) 111: 1797. 160 006 IHC; tested species: mouse
Microglia monitor and protect neuronal function through specialized somatic purinergic junctions.
Cserép C, Pósfai B, Lénárt N, Fekete R, László ZI, Lele Z, Orsolits B, Molnár G, Heindl S, Schwarcz AD, Ujvári K, et al.
Science (New York, N.Y.) (2020) 3676477: 528-537. 160 006 IHC; tested species: mouse
Short-chain fatty acids improve post-stroke recovery via immunological mechanisms.
Sadler R, Cramer JV, Heindl S, Kostidis S, Betz D, Zuurbier KR, Northoff BH, Heijink M, Goldberg MP, Plautz EJ, Roth S, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 160 006 IHC; tested species: mouse
Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation.
Jafari M, Schumacher AM, Snaidero N, Ullrich Gavilanes EM, Neziraj T, Kocsis-Jutka V, Engels D, Jürgens T, Wagner I, Weidinger JDF, Schmidt SS, et al.
Nature neuroscience (2021) 243: 355-367. 160 006 IHC-P; tested species: mouse
P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer's disease model.
Reichenbach N, Delekate A, Breithausen B, Keppler K, Poll S, Schulte T, Peter J, Plescher M, Hansen JN, Blank N, Keller A, et al.
The Journal of experimental medicine (2018) : . 160 006 IHC-P; tested species: mouse
Protecting RNA quality for spatial transcriptomics while improving immunofluorescent staining quality.
Hahn N, Bens M, Kempfer M, Reißig C, Schmidl L, Geis C
Frontiers in neuroscience (2023) 17: 1198154. 160 006 IHC-Fr; tested species: mouse
Cationic peptides erase memories by removing synaptic AMPA receptors through endophilin-mediated endocytosis.
Beier K, Stokes E, Zhuang Y, Toledano M, Vasquez J, Azouz G, Hui M, Tyler I, Shi X, Aoto J
Research square (2023) : . 160 006 ICC, ExM; tested species: mouse
Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein.
Brzozowski CF, Hijaz BA, Singh V, Gcwensa NZ, Kelly K, Boyden ES, West AB, Sarkar D, Volpicelli-Daley LA
Acta neuropathologica communications (2021) 91: 180. 160 006 ICC, IHC, ExM; tested species: mouse
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ICC
IHC
IHC-P
ExM
Background

Homer is a scaffolding protein of the post synaptic density (PSD) and enriched at excitatory synapses. The protein binds metabotropic glutamate receptors, TRPC1, proteins of the Shank family and others. By aggregating these proteins into clusters, homer was suggested to organize distinct signalling domains.
Three isoforms, Homer 1, 2 and 3 have been described. Each of these isoforms is subject to alternative splicing yielding the splice variants a, b, c, d.
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