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Homer 1 - 160 006

A post synaptic density (PSD) protein involved in the targeting of glutamate receptors
Polyclonal chicken purified antibody
Cat. No.: 160 006
Amount: 50 µg
Price: $395.00
Cat. No. 160 006 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 1000 gallery  
IHC: 1 : 500 (see remarks) gallery  
IHC-P/FFPE: 1 : 500 gallery  
Immunogen Recombinant protein corresponding to AA 1 to 196 from human Homer1 (UniProt Id: Q86YM7)
Reactivity Reacts with: human (Q86YM7), rat (Q9Z214), mouse (Q9Z2Y3).
Other species not tested yet.
Specificity Specific for Homer 1. According to Soloviev et al. (2000), aa 1 - 180 are present in isoforms a, b, c and d.
Matching control protein/peptide 160-0P
Remarks

IHC: Fix for 15 min with 4% PFA and 15% picric acid in PBS.

Data sheet 160_006.pdf

References for Homer 1 - 160 006

Pyk2 overexpression in postsynaptic neurons blocks amyloid β1-42-induced synaptotoxicity in microfluidic co-cultures.
Kilinc D, Vreulx AC, Mendes T, Flaig A, Marques-Coelho D, Verschoore M, Demiautte F, Amouyel P,  , Eysert F, Dourlen P, et al.
Brain communications (2020) 22: fcaa139. 160 006 ICC; tested species: rat
Gabapentinoid treatment promotes corticospinal plasticity and regeneration following murine spinal cord injury.
Sun W, Larson MJ, Kiyoshi CM, Annett AJ, Stalker WA, Peng J, Tedeschi A
The Journal of clinical investigation (2020) 1301: 345-358. 160 006 IHC; tested species: mouse
Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations.
Xu ZX, Kim GH, Tan JW, Riso AE, Sun Y, Xu EY, Liao GY, Xu H, Lee SH, Do NY, Lee CH, et al.
Nature communications (2020) 111: 1797. 160 006 IHC; tested species: mouse
Short-chain fatty acids improve post-stroke recovery via immunological mechanisms.
Sadler R, Cramer JV, Heindl S, Kostidis S, Betz D, Zuurbier KR, Northoff BH, Heijink M, Goldberg MP, Plautz EJ, Roth S, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 160 006 IHC; tested species: mouse
P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer's disease model.
Reichenbach N, Delekate A, Breithausen B, Keppler K, Poll S, Schulte T, Peter J, Plescher M, Hansen JN, Blank N, Keller A, et al.
The Journal of experimental medicine (2018) : . 160 006 IHC-P; tested species: mouse
Cat. No.: 160 006
Quantity: 50 µg
Price: $395.00
Pyk2 overexpression in postsynaptic neurons blocks amyloid β1-42-induced synaptotoxicity in microfluidic co-cultures.
Kilinc D, Vreulx AC, Mendes T, Flaig A, Marques-Coelho D, Verschoore M, Demiautte F, Amouyel P,  , Eysert F, Dourlen P, et al.
Brain communications (2020) 22: fcaa139. 160 006 ICC; tested species: rat
Gabapentinoid treatment promotes corticospinal plasticity and regeneration following murine spinal cord injury.
Sun W, Larson MJ, Kiyoshi CM, Annett AJ, Stalker WA, Peng J, Tedeschi A
The Journal of clinical investigation (2020) 1301: 345-358. 160 006 IHC; tested species: mouse
Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations.
Xu ZX, Kim GH, Tan JW, Riso AE, Sun Y, Xu EY, Liao GY, Xu H, Lee SH, Do NY, Lee CH, et al.
Nature communications (2020) 111: 1797. 160 006 IHC; tested species: mouse
Short-chain fatty acids improve post-stroke recovery via immunological mechanisms.
Sadler R, Cramer JV, Heindl S, Kostidis S, Betz D, Zuurbier KR, Northoff BH, Heijink M, Goldberg MP, Plautz EJ, Roth S, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 160 006 IHC; tested species: mouse
P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer's disease model.
Reichenbach N, Delekate A, Breithausen B, Keppler K, Poll S, Schulte T, Peter J, Plescher M, Hansen JN, Blank N, Keller A, et al.
The Journal of experimental medicine (2018) : . 160 006 IHC-P; tested species: mouse
Background

Homer is a scaffolding protein of the post synaptic density (PSD) and enriched at excitatory synapses. The protein binds metabotropic glutamate receptors, TRPC1, proteins of the Shank family and others. By aggregating these proteins into clusters, homer was suggested to organize distinct signalling domains.
Three isoforms, Homer 1, 2 and 3 have been described. Each of these isoforms is subject to alternative splicing yielding the splice variants a, b, c, d.