Cat. No.: 160 019
Amount: 50 µg
Price:
$410.00
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| Cat. No. 160 019 |
50 µg purified recombinant IgY, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Clone | Ch72G2 |
| Subtype | IgY (λ light chain) |
| Immunogen | Recombinant protein corresponding to the c-terminal half of human Homer1b (UniProt Id: Q86YM7-1) |
| Reactivity |
Reacts with: mouse (Q9Z2Y3), rat (Q9Z214), human (Q86YM7-1). Other species not tested yet. |
| Remarks |
This antibody is a chimeric antibody based on the monoclonal mouse antibody 72G2. The constant regions of the heavy and light chains have been replaced by chicken specific sequences. The antibody can therefore be used with standard anti-chicken secondary reagents. The antibody has been expressed in mammalian cells. |
| Data sheet | 160_019.pdf |
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Homer is a scaffolding protein of the post synaptic density (PSD) and enriched at excitatory synapses. The protein binds metabotropic glutamate receptors, TRPC1, proteins of the Shank family and others. By aggregating these proteins into clusters, homer was suggested to organize distinct signalling domains.
Three isoforms, Homer1, 2 and 3 have been described. Each of these isoforms is subject to alternative splicing yielding the splice variants a, b, c, d.