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Home > Products > 160 002

Homer1 antibody - 160 002

Homer1 , 2 and 3 are post synaptic density (PSD) proteins involved in the targeting of glutamate receptors
Rabbit polyclonal antiserum
Cat. No.: 160 002
Amount: 200 µl
Price: $365.00
Cat. No. 160 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 500 up to 1 : 1000 (see remarks) gallery  
IHC: yes
IHC-P: 1 : 500 gallery  
ExM: yes (see remarks) gallery  
Immunogen Recombinant protein corresponding to the N-terminal half of human Homer 1 (UniProt Id: Q86YM7)
Reactivity Reacts with: human (Q86YM7), rat (Q9Z214), mouse (Q9Z2Y3).
Other species not tested yet.
Specificity Specific for Homer 1. Cross-reactivity of the serum to Homer 2 and 3 was removed by pre-adsorption with Homer 2 (aa 1 - 176) and Homer 3 (aa 1 - 177).
According to Soloviev et al. (2000), aa 1 - 180 are present in isoforms a, b, c and d.
Matching control protein/peptide 160-0P
Remarks

ICC: PFA fixation is recommended.
ExM: This antibody has been successfully used for the epitope-preserving magnified analysis of the proteome (eMAP) expansion microscopy method (Park et al. 2021. PMID: 34767453).
Data sheet 160_002.pdf

References for Homer1 - 160 002

S-acylation of the Wnt receptor Frizzled-5 by zDHHC5 controls its cellular localization and synaptogenic activity in the rodent hippocampus.
Teo S, Bossio A, Stamatakou E, Pascual-Vargas P, Jones ME, Schuhmacher LN, Salinas PC
Developmental cell (2023) 5820: 2063-2079.e9. 160 002 WB; tested species: rat
Differential α2A- and α2C-adrenoceptor protein expression in presynaptic and postsynaptic density fractions of postmortem human prefrontal cortex.
Erdozain AM, Brocos-Mosquera I, Gabilondo AM, Meana JJ, Callado LF
Journal of psychopharmacology (Oxford, England) (2018) : 269881118798612. 160 002 WB; tested species: human
Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies.
Dejanovic B, Huntley MA, De Mazière A, Meilandt WJ, Wu T, Srinivasan K, Jiang Z, Gandham V, Friedman BA, Ngu H, Foreman O, et al.
Neuron (2018) : . 160 002 WB, ICC; tested species: mouse
Microtubule-associated protein 1B (MAP1B)-deficient neurons show structural presynaptic deficiencies in vitro and altered presynaptic physiology.
Bodaleo FJ, Montenegro-Venegas C, Henríquez DR, Court FA, Gonzalez-Billault C
Scientific reports (2016) 6: 30069. 160 002 WB, ICC
Altered postsynaptic-density-levels of caldendrin in the para-chloroamphetamine-induced serotonin syndrome but not in the rat ketamine model of psychosis.
Smalla KH, Sahin J, Putzke J, Tischmeyer W, Gundelfinger ED, Kreutz MR
Neurochemical research (2009) 348: 1405-9. 160 002 WB
Cat. No.: 160 002
Amount: 200 µl
Price: $365.00
WB
ICC
IHC-P
ExM
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