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Homer 1 antibody - 160 002

Homer1 , 2 and 3 are post synaptic density (PSD) proteins involved in the targeting of glutamate receptors
Rabbit polyclonal antiserum
Cat. No.: 160 002
Amount: 200 µl
Price: $350.00
Cat. No. 160 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 500 up to 1 : 1000 (see remarks) gallery  
IHC: yes
IHC-P: 1 : 500 gallery  
Immunogen Recombinant protein corresponding to the N-terminal half of human Homer 1 (UniProt Id: Q86YM7)
Reactivity Reacts with: human (Q86YM7), rat (Q9Z214), mouse (Q9Z2Y3).
Other species not tested yet.
Specificity Specific for Homer 1. Cross-reactivity of the serum to Homer 2 and 3 was removed by pre-adsorption with Homer 2 (aa 1 - 176) and Homer 3 (aa 1 - 177).
According to Soloviev et al. (2000), aa 1 - 180 are present in isoforms a, b, c and d.
Matching control protein/peptide 160-0P
Remarks

ICC: PFA fixation is recommended.

Data sheet 160_002.pdf

References for Homer 1 - 160 002

Differential α2A- and α2C-adrenoceptor protein expression in presynaptic and postsynaptic density fractions of postmortem human prefrontal cortex.
Erdozain AM, Brocos-Mosquera I, Gabilondo AM, Meana JJ, Callado LF
Journal of psychopharmacology (Oxford, England) (2018) : 269881118798612. 160 002 WB; tested species: human
Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies.
Dejanovic B, Huntley MA, De Mazière A, Meilandt WJ, Wu T, Srinivasan K, Jiang Z, Gandham V, Friedman BA, Ngu H, Foreman O, et al.
Neuron (2018) : . 160 002 WB, ICC; tested species: mouse
Microtubule-associated protein 1B (MAP1B)-deficient neurons show structural presynaptic deficiencies in vitro and altered presynaptic physiology.
Bodaleo FJ, Montenegro-Venegas C, Henríquez DR, Court FA, Gonzalez-Billault C
Scientific reports (2016) 6: 30069. 160 002 WB, ICC
Altered postsynaptic-density-levels of caldendrin in the para-chloroamphetamine-induced serotonin syndrome but not in the rat ketamine model of psychosis.
Smalla KH, Sahin J, Putzke J, Tischmeyer W, Gundelfinger ED, Kreutz MR
Neurochemical research (2009) 348: 1405-9. 160 002 WB
C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation.
Lall D, Lorenzini I, Mota TA, Bell S, Mahan TE, Ulrich JD, Davtyan H, Rexach JE, Muhammad AKMG, Shelest O, Landeros J, et al.
Neuron (2021) 10914: 2275-2291.e8. 160 002 ICC; tested species: mouse
Action potential-coupled Rho GTPase signaling drives presynaptic plasticity.
O'Neil SD, Rácz B, Brown WE, Gao Y, Soderblom EJ, Yasuda R, Soderling SH
eLife (2021) 10: . 160 002 ICC; tested species: mouse
Cnksr2 Loss in Mice Leads to Increased Neural Activity and Behavioral Phenotypes of Epilepsy-Aphasia Syndrome.
Erata E, Gao Y, Purkey AM, Soderblom EJ, McNamara JO, Soderling SH
The Journal of neuroscience : the official journal of the Society for Neuroscience (2021) 4146: 9633-9649. 160 002 ICC; tested species: mouse
Comparison of Multiscale Imaging Methods for Brain Research.
Tröger J, Hoischen C, Perner B, Monajembashi S, Barbotin A, Löschberger A, Eggeling C, Kessels MM, Qualmann B, Hemmerich P
Cells (2020) 96: . 160 002 ICC, IHC; tested species: mouse,rat
Chemico-genetic discovery of astrocytic control of inhibition in vivo.
Takano T, Wallace JT, Baldwin KT, Purkey AM, Uezu A, Courtland JL, Soderblom EJ, Shimogori T, Maness PF, Eroglu C, Soderling SH, et al.
Nature (2020) : . 160 002 ICC; tested species: mouse
In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation.
Spence EF, Dube S, Uezu A, Locke M, Soderblom EJ, Soderling SH
Nature communications (2019) 101: 386. 160 002 ICC; tested species: mouse
Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons.
Marro SG, Chanda S, Yang N, Janas JA, Valperga G, Trotter J, Zhou B, Merrill S, Yousif I, Shelby H, Vogel H, et al.
Neuron (2019) 1034: 617-626.e6. 160 002 ICC; tested species: human
APC2 controls dendrite development by promoting microtubule dynamics.
Kahn OI, Schätzle P, van de Willige D, Tas RP, Lindhout FW, Portegies S, Kapitein LC, Hoogenraad CC
Nature communications (2018) 91: 2773. 160 002 ICC; tested species: rat
Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies.
Dejanovic B, Huntley MA, De Mazière A, Meilandt WJ, Wu T, Srinivasan K, Jiang Z, Gandham V, Friedman BA, Ngu H, Foreman O, et al.
Neuron (2018) : . 160 002 WB, ICC; tested species: mouse
Microtubule-associated protein 1B (MAP1B)-deficient neurons show structural presynaptic deficiencies in vitro and altered presynaptic physiology.
Bodaleo FJ, Montenegro-Venegas C, Henríquez DR, Court FA, Gonzalez-Billault C
Scientific reports (2016) 6: 30069. 160 002 WB, ICC
Miro1-dependent mitochondrial dynamics in parvalbumin interneurons.
Kontou G, Antonoudiou P, Podpolny M, Szulc BR, Arancibia-Carcamo IL, Higgs NF, Lopez-Domenech G, Salinas PC, Mann EO, Kittler JT
eLife (2021) 10: . 160 002 IHC; tested species: mouse
IL-1 reprogramming of adult neural stem cells limits neurocognitive recovery after viral encephalitis by maintaining a proinflammatory state.
Soung AL, Davé VA, Garber C, Tycksen ED, Vollmer LL, Klein RS
Brain, behavior, and immunity (2021) : . 160 002 IHC; tested species: mouse
Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans.
Courtland JL, Bradshaw TW, Waitt G, Soderblom EJ, Ho T, Rajab A, Vancini R, Kim IH, Soderling SH
eLife (2021) 10: . 160 002 IHC; tested species: mouse
Synapse development is regulated by microglial THIK-1 K+ channels.
Izquierdo P, Shiina H, Hirunpattarasilp C, Gillis G, Attwell D
Proceedings of the National Academy of Sciences of the United States of America (2021) 11842: . 160 002 IHC; tested species: mouse
Comparison of Multiscale Imaging Methods for Brain Research.
Tröger J, Hoischen C, Perner B, Monajembashi S, Barbotin A, Löschberger A, Eggeling C, Kessels MM, Qualmann B, Hemmerich P
Cells (2020) 96: . 160 002 ICC, IHC; tested species: mouse,rat
AP180 promotes release site clearance and clathrin-dependent vesicle reformation in mouse cochlear inner hair cells.
Kroll J, Özçete ÖD, Jung S, Maritzen T, Milosevic I, Wichmann C, Moser T
Journal of cell science (2020) 1332: . 160 002 IHC; tested species: mouse
Dorsal Horn Gastrin-Releasing Peptide Expressing Neurons Transmit Spinal Itch But Not Pain Signals.
Albisetti GW, Pagani M, Platonova E, Hösli L, Johannssen HC, Fritschy JM, Wildner H, Zeilhofer HU
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 160 002 IHC; tested species: mouse
In Vivo Protein Complementation Demonstrates Presynaptic α-Synuclein Oligomerization and Age-Dependent Accumulation of 8-16-mer Oligomer Species.
Kiechle M, von Einem B, Höfs L, Voehringer P, Grozdanov V, Markx D, Parlato R, Wiesner D, Mayer B, Sakk O, Baumann B, et al.
Cell reports (2019) 299: 2862-2874.e9. 160 002 IHC; tested species: rat
Semaphorin4D Induces Inhibitory Synapse Formation by Rapid Stabilization of Presynaptic Boutons via MET Coactivation.
Frias CP, Liang J, Bresser T, Scheefhals L, van Kesteren M, van Dorland R, Hu HY, Bodzeta A, van Bergen En Henegouwen PMP, Hoogenraad CC, Wierenga CJ, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) 3922: 4221-4237. 160 002 IHC; tested species: mouse
Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican.
Favuzzi E, Marques-Smith A, Deogracias R, Winterflood CM, Sánchez-Aguilera A, Mantoan L, Maeso P, Fernandes C, Ewers H, Rico B
Neuron (2017) 953: 639-655.e10. 160 002 IHC; tested species: mouse
Identification of Two Classes of Somatosensory Neurons That Display Resistance to Retrograde Infection by Rabies Virus.
Albisetti GW, Ghanem A, Foster E, Conzelmann KK, Zeilhofer HU, Wildner H
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 3743: 10358-10371. 160 002 IHC; tested species: mouse
Contribution of the astrocytic tau pathology to synapse loss in progressive supranuclear palsy and corticobasal degeneration.
Briel N, Pratsch K, Roeber S, Arzberger T, Herms J
Brain pathology (Zurich, Switzerland) (2021) 314: e12914. 160 002 IHC-P; tested species: human
Cat. No.: 160 002
Amount: 200 µl
Price: $350.00
Differential α2A- and α2C-adrenoceptor protein expression in presynaptic and postsynaptic density fractions of postmortem human prefrontal cortex.
Erdozain AM, Brocos-Mosquera I, Gabilondo AM, Meana JJ, Callado LF
Journal of psychopharmacology (Oxford, England) (2018) : 269881118798612. 160 002 WB; tested species: human
Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies.
Dejanovic B, Huntley MA, De Mazière A, Meilandt WJ, Wu T, Srinivasan K, Jiang Z, Gandham V, Friedman BA, Ngu H, Foreman O, et al.
Neuron (2018) : . 160 002 WB, ICC; tested species: mouse
Microtubule-associated protein 1B (MAP1B)-deficient neurons show structural presynaptic deficiencies in vitro and altered presynaptic physiology.
Bodaleo FJ, Montenegro-Venegas C, Henríquez DR, Court FA, Gonzalez-Billault C
Scientific reports (2016) 6: 30069. 160 002 WB, ICC
Altered postsynaptic-density-levels of caldendrin in the para-chloroamphetamine-induced serotonin syndrome but not in the rat ketamine model of psychosis.
Smalla KH, Sahin J, Putzke J, Tischmeyer W, Gundelfinger ED, Kreutz MR
Neurochemical research (2009) 348: 1405-9. 160 002 WB
C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation.
Lall D, Lorenzini I, Mota TA, Bell S, Mahan TE, Ulrich JD, Davtyan H, Rexach JE, Muhammad AKMG, Shelest O, Landeros J, et al.
Neuron (2021) 10914: 2275-2291.e8. 160 002 ICC; tested species: mouse
Action potential-coupled Rho GTPase signaling drives presynaptic plasticity.
O'Neil SD, Rácz B, Brown WE, Gao Y, Soderblom EJ, Yasuda R, Soderling SH
eLife (2021) 10: . 160 002 ICC; tested species: mouse
Cnksr2 Loss in Mice Leads to Increased Neural Activity and Behavioral Phenotypes of Epilepsy-Aphasia Syndrome.
Erata E, Gao Y, Purkey AM, Soderblom EJ, McNamara JO, Soderling SH
The Journal of neuroscience : the official journal of the Society for Neuroscience (2021) 4146: 9633-9649. 160 002 ICC; tested species: mouse
Comparison of Multiscale Imaging Methods for Brain Research.
Tröger J, Hoischen C, Perner B, Monajembashi S, Barbotin A, Löschberger A, Eggeling C, Kessels MM, Qualmann B, Hemmerich P
Cells (2020) 96: . 160 002 ICC, IHC; tested species: mouse,rat
Chemico-genetic discovery of astrocytic control of inhibition in vivo.
Takano T, Wallace JT, Baldwin KT, Purkey AM, Uezu A, Courtland JL, Soderblom EJ, Shimogori T, Maness PF, Eroglu C, Soderling SH, et al.
Nature (2020) : . 160 002 ICC; tested species: mouse
In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation.
Spence EF, Dube S, Uezu A, Locke M, Soderblom EJ, Soderling SH
Nature communications (2019) 101: 386. 160 002 ICC; tested species: mouse
Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons.
Marro SG, Chanda S, Yang N, Janas JA, Valperga G, Trotter J, Zhou B, Merrill S, Yousif I, Shelby H, Vogel H, et al.
Neuron (2019) 1034: 617-626.e6. 160 002 ICC; tested species: human
APC2 controls dendrite development by promoting microtubule dynamics.
Kahn OI, Schätzle P, van de Willige D, Tas RP, Lindhout FW, Portegies S, Kapitein LC, Hoogenraad CC
Nature communications (2018) 91: 2773. 160 002 ICC; tested species: rat
Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies.
Dejanovic B, Huntley MA, De Mazière A, Meilandt WJ, Wu T, Srinivasan K, Jiang Z, Gandham V, Friedman BA, Ngu H, Foreman O, et al.
Neuron (2018) : . 160 002 WB, ICC; tested species: mouse
Microtubule-associated protein 1B (MAP1B)-deficient neurons show structural presynaptic deficiencies in vitro and altered presynaptic physiology.
Bodaleo FJ, Montenegro-Venegas C, Henríquez DR, Court FA, Gonzalez-Billault C
Scientific reports (2016) 6: 30069. 160 002 WB, ICC
Miro1-dependent mitochondrial dynamics in parvalbumin interneurons.
Kontou G, Antonoudiou P, Podpolny M, Szulc BR, Arancibia-Carcamo IL, Higgs NF, Lopez-Domenech G, Salinas PC, Mann EO, Kittler JT
eLife (2021) 10: . 160 002 IHC; tested species: mouse
IL-1 reprogramming of adult neural stem cells limits neurocognitive recovery after viral encephalitis by maintaining a proinflammatory state.
Soung AL, Davé VA, Garber C, Tycksen ED, Vollmer LL, Klein RS
Brain, behavior, and immunity (2021) : . 160 002 IHC; tested species: mouse
Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans.
Courtland JL, Bradshaw TW, Waitt G, Soderblom EJ, Ho T, Rajab A, Vancini R, Kim IH, Soderling SH
eLife (2021) 10: . 160 002 IHC; tested species: mouse
Synapse development is regulated by microglial THIK-1 K+ channels.
Izquierdo P, Shiina H, Hirunpattarasilp C, Gillis G, Attwell D
Proceedings of the National Academy of Sciences of the United States of America (2021) 11842: . 160 002 IHC; tested species: mouse
Comparison of Multiscale Imaging Methods for Brain Research.
Tröger J, Hoischen C, Perner B, Monajembashi S, Barbotin A, Löschberger A, Eggeling C, Kessels MM, Qualmann B, Hemmerich P
Cells (2020) 96: . 160 002 ICC, IHC; tested species: mouse,rat
AP180 promotes release site clearance and clathrin-dependent vesicle reformation in mouse cochlear inner hair cells.
Kroll J, Özçete ÖD, Jung S, Maritzen T, Milosevic I, Wichmann C, Moser T
Journal of cell science (2020) 1332: . 160 002 IHC; tested species: mouse
Dorsal Horn Gastrin-Releasing Peptide Expressing Neurons Transmit Spinal Itch But Not Pain Signals.
Albisetti GW, Pagani M, Platonova E, Hösli L, Johannssen HC, Fritschy JM, Wildner H, Zeilhofer HU
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 160 002 IHC; tested species: mouse
In Vivo Protein Complementation Demonstrates Presynaptic α-Synuclein Oligomerization and Age-Dependent Accumulation of 8-16-mer Oligomer Species.
Kiechle M, von Einem B, Höfs L, Voehringer P, Grozdanov V, Markx D, Parlato R, Wiesner D, Mayer B, Sakk O, Baumann B, et al.
Cell reports (2019) 299: 2862-2874.e9. 160 002 IHC; tested species: rat
Semaphorin4D Induces Inhibitory Synapse Formation by Rapid Stabilization of Presynaptic Boutons via MET Coactivation.
Frias CP, Liang J, Bresser T, Scheefhals L, van Kesteren M, van Dorland R, Hu HY, Bodzeta A, van Bergen En Henegouwen PMP, Hoogenraad CC, Wierenga CJ, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) 3922: 4221-4237. 160 002 IHC; tested species: mouse
Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican.
Favuzzi E, Marques-Smith A, Deogracias R, Winterflood CM, Sánchez-Aguilera A, Mantoan L, Maeso P, Fernandes C, Ewers H, Rico B
Neuron (2017) 953: 639-655.e10. 160 002 IHC; tested species: mouse
Identification of Two Classes of Somatosensory Neurons That Display Resistance to Retrograde Infection by Rabies Virus.
Albisetti GW, Ghanem A, Foster E, Conzelmann KK, Zeilhofer HU, Wildner H
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 3743: 10358-10371. 160 002 IHC; tested species: mouse
Contribution of the astrocytic tau pathology to synapse loss in progressive supranuclear palsy and corticobasal degeneration.
Briel N, Pratsch K, Roeber S, Arzberger T, Herms J
Brain pathology (Zurich, Switzerland) (2021) 314: e12914. 160 002 IHC-P; tested species: human
Background

Homer is a scaffolding protein of the post synaptic density (PSD) and enriched at excitatory synapses. The protein binds metabotropic glutamate receptors, TRPC1, proteins of the Shank family and others. By aggregating these proteins into clusters, homer was suggested to organize distinct signalling domains.
Three isoforms, Homer 1, 2 and 3 have been described. Each of these isoforms is subject to alternative splicing yielding the splice variants a, b, c, d.