Cat. No.: 141 318
Amount: 50 µg
Price:
$415.00
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| Cat. No. 141 318 |
50 µg purified recombinant IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Clone | Gp179H11A2 |
| Subtype | IgG2 (κ light chain) |
| Immunogen | Recombinant protein corresponding to residues near the central region of rat Bassoon. (UniProt Id: O88778) |
| Reactivity |
Reacts with: mouse (O88737), rat (O88778). Other species not tested yet. |
| Specificity | Specific for Bassoon K.O. validated |
| Remarks |
This antibody is a chimeric antibody based on the monoclonal mouse antibody clone 179H11A2. The constant regions of the heavy and light chains have been replaced by guinea pig specific sequences. Therefore, the antibody can be used with standard anti-guinea pig secondary reagents. The antibody has been expressed in mammalian cells. |
| Data sheet | 141_318.pdf |
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Bassoon is a large protein which consists of an N-terminal Zn2+ finger and several piccolo-bassoon homology domains (PBH-domains). It is generally found together with piccolo, a related huge multi-domain protein of the CAZ (cytoskeletal matrix assembled at active zones).
Bassoon was suggested to be a scaffolding element of the presynapse but deletion experiments in mice have shown that bassoon is also involved in synaptic vesicle cycling. Probably bassoon interacts with other protein factors via its Zn2+ domain but the potential partners have not been determined yet.