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alpha/beta Synuclein - 128 011

A protein involved in Parkinson's and Alzheimer's Disease
Monoclonal mouse purified IgG
Cat. No.: 128 011
Amount: 100 µg
Price: $415.00
Cat. No. 128 011 100 µg purified IgG, lyophilized. Azide was added before lyophilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 500 gallery  
IHC: 1 : 200 gallery  
IHC-P/FFPE: 1 : 500 gallery  
ELISA: yes (see remarks)
Clone 94C1
Subtype IgG2b (κ light chain)
Immunogen Synthetic peptide corresponding to AA 126 to 140 from human α-Synuclein (UniProt Id: P37840)
Epitop Epitop: AA 126 to 140 from human α-Synuclein (UniProt Id: P37840)
Reactivity Reacts with: human (P37840, Q16143), rat (P37377, Q63754), mouse (O55042, Q91ZZ3), mammals.
Other species not tested yet.
Peptide conserved in almost all mammals.
Specificity Recognizes α- and β-synuclein, no cross-reactivity to γ-synuclein.
Remarks

ELISA: This antibody is suitable as capture antibody for sandwich-ELISA with cat. no. 128 003 as detector antibody.

Data sheet 128_011.pdf
Cat. No.: 128 011
Quantity: 100 µg
Price: $415.00
Background
Synuclein proteins are produced by three genes. They share structural resemblance to apolipoproteins, but are abundant in the neuronal cytosol and present in enriched amounts at presynaptic terminals.
Synucleins have been specifically implicated in three diseases: Alzheimer's (AD), Parkinson's (PD) and breast cancer. In AD, a peptide derived from α-synuclein forms an intrinsic component of plaque amyloid. In PD, an α-synuclein allele is genetically linked to several independent familial cases, and the protein appears to accumulate in Lewy bodies. In breast cancer, increased expression of γ-synuclein correlates with disease progression.
In songbirds, α-synuclein expression is correlated with plasticity in the developing song control system. Although the normal function of synucleins is unknown, a role in synaptic plasticity seems likely.