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alpha/beta Synuclein - 128 003

A protein involved in Parkinson's and Alzheimer's Disease
Polyclonal rabbit purified antibody
Cat. No.: 128 003
Amount: 50 µg
Price: $450.00
Cat. No. 128 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P/FFPE: 1 : 200 gallery  
ELISA: yes (see remarks)
Immunogen Synthetic peptide corresponding to AA 2 to 25 from human α-Synuclein (UniProt Id: P37840)
Reactivity Reacts with: rat (P37377, Q63754), mouse (O55042, Q91ZZ3), zebrafish, human (P37840, Q16143).
Other species not tested yet.
Specificity Recognizes α synuclein and β synuclein.
Remarks

ELISA: This antibody is suitable as detector antibody for sandwich-ELISA with cat. no. 128 011 or 128 211 as capture antibodies.

Data sheet 128_003.pdf

References for alpha/beta Synuclein - 128 003

Automated highly multiplexed super-resolution imaging of protein nano-architecture in cells and tissues.
Klevanski M, Herrmannsdoerfer F, Sass S, Venkataramani V, Heilemann M, Kuner T
Nature communications (2020) 111: 1552. 128 003 IHC; tested species: rat
Cat. No.: 128 003
Quantity: 50 µg
Price: $450.00
Automated highly multiplexed super-resolution imaging of protein nano-architecture in cells and tissues.
Klevanski M, Herrmannsdoerfer F, Sass S, Venkataramani V, Heilemann M, Kuner T
Nature communications (2020) 111: 1552. 128 003 IHC; tested species: rat
Background
Synuclein proteins are produced by three genes. They share structural resemblance to apolipoproteins, but are abundant in the neuronal cytosol and present in enriched amounts at presynaptic terminals.
Synucleins have been specifically implicated in three diseases: Alzheimer's (AD), Parkinson's (PD) and breast cancer. In AD, a peptide derived from α-synuclein forms an intrinsic component of plaque amyloid. In PD, an α-synuclein allele is genetically linked to several independent familial cases, and the protein appears to accumulate in Lewy bodies. In breast cancer, increased expression of γ-synuclein correlates with disease progression.
In songbirds, α-synuclein expression is correlated with plasticity in the developing song control system. Although the normal function of synucleins is unknown, a role in synaptic plasticity seems likely.