Cat. No.: 110 053BT
Amount: 50 µg
Price:
$480.00
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| Cat. No. 110 053BT |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen, labeled with Biotin.
Biotin is a small vitamin B complex molecule. Its small size minimizes interference with antibody binding sites and allows for efficient conjugation without compromising antibody functionality. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications |
IP: yes ICC: 1 : 100 gallery IHC: not tested yet IHC-P: not tested yet |
| Label | biotin |
| Immunogen | Recombinant protein corresponding to AA 1 to 279 from mouse Syntaxin5 (UniProt Id: Q8K1E0) |
| Reactivity |
Reacts with: human (Q13190), rat (Q08851), mouse (Q8K1E0), hamster. Other species not tested yet. |
| Matching control protein/peptide | 110-5P |
| Remarks |
This antibody detects the 35 kDa and 42 kDa variants of syntaxin 5. |
| Data sheet | 110_053bt.pdf |
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Syntaxin 5, a member of the SNARE family of proteins, is functionally related to the yeast protein Sed5p. Two syntaxin 5 isoforms (35 and 42 kDa) have been described which are generated from the same mRNA by alternative translation initiation. The longer 42 kDa variant contains an N-terminal extension carrying a putative type II ER-retrieval signal.
Syntaxin 5 forms a SNARE complex with membrin, GOSR 1, rbet1 and rsec22. A more detailed analysis revealed two subcomplexes within this complex. One contains syntaxin 5 (mainly the shorter 35 kDa variant) and GOSR 1 whereas the other is composed of syntaxin 5 (35 and 42 kDa variant), membrin, rsec22 and rbet1.
Recently syntaxin 5 has been shown to be involved in the processing and accumulation of β-APP in neuronal cells.