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Membrin antibody - 170 003

Membrin is a SNARE protein involved in ER-Golgi transport
Rabbit polyclonal purified antibody
Cat. No.: 170 003
Amount: 50 µg
Price: $370.00
Cat. No. 170 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 100 up to 1 : 1000 gallery  
IHC: not tested yet
IHC-P/FFPE: not tested yet
Immunogen Recombinant protein corresponding to AA 2 to 190 from rat Membrin (UniProt Id: O35165)
Reactivity Reacts with: rat (O35165), mouse (O35166), human (O14653).
Other species not tested yet.
Specificity Specific for membrin.
Data sheet 170_003.pdf

References for Membrin - 170 003

BET1 variants establish impaired vesicular transport as a cause for muscular dystrophy with epilepsy.
Donkervoort S, Krause N, Dergai M, Yun P, Koliwer J, Gorokhova S, Geist Hauserman J, Cummings BB, Hu Y, Smith R, Uapinyoying P, et al.
EMBO molecular medicine (2021) : e13787. 170 003 WB, ICC; tested species: human,mouse
A trap mutant reveals the physiological client spectrum of TRC40.
Coy-Vergara J, Rivera-Monroy J, Urlaub H, Lenz C, Schwappach B
Journal of cell science (2019) 13213: . 170 003 WB; tested species: human
COG6 interacts with a subset of the Golgi SNAREs and is important for the Golgi complex integrity.
Kudlyk T, Willett R, Pokrovskaya ID, Lupashin V
Traffic (Copenhagen, Denmark) (2013) 142: 194-204. 170 003 WB
BET1 variants establish impaired vesicular transport as a cause for muscular dystrophy with epilepsy.
Donkervoort S, Krause N, Dergai M, Yun P, Koliwer J, Gorokhova S, Geist Hauserman J, Cummings BB, Hu Y, Smith R, Uapinyoying P, et al.
EMBO molecular medicine (2021) : e13787. 170 003 WB, ICC; tested species: human,mouse
Cat. No.: 170 003
Amount: 50 µg
Price: $370.00
BET1 variants establish impaired vesicular transport as a cause for muscular dystrophy with epilepsy.
Donkervoort S, Krause N, Dergai M, Yun P, Koliwer J, Gorokhova S, Geist Hauserman J, Cummings BB, Hu Y, Smith R, Uapinyoying P, et al.
EMBO molecular medicine (2021) : e13787. 170 003 WB, ICC; tested species: human,mouse
A trap mutant reveals the physiological client spectrum of TRC40.
Coy-Vergara J, Rivera-Monroy J, Urlaub H, Lenz C, Schwappach B
Journal of cell science (2019) 13213: . 170 003 WB; tested species: human
COG6 interacts with a subset of the Golgi SNAREs and is important for the Golgi complex integrity.
Kudlyk T, Willett R, Pokrovskaya ID, Lupashin V
Traffic (Copenhagen, Denmark) (2013) 142: 194-204. 170 003 WB
BET1 variants establish impaired vesicular transport as a cause for muscular dystrophy with epilepsy.
Donkervoort S, Krause N, Dergai M, Yun P, Koliwer J, Gorokhova S, Geist Hauserman J, Cummings BB, Hu Y, Smith R, Uapinyoying P, et al.
EMBO molecular medicine (2021) : e13787. 170 003 WB, ICC; tested species: human,mouse
Background

Membrin also known as GOSR 2, GS 27 and GOS 27 is a 27 kDa membrane protein on the surface of the Golgi compartment. It has been shown to serve as a tSNARE in ER to Golgi transport.
In co-immunoprecipitation studies membrin was identified as a member of a SNARE complex consisting of syntaxin 5, GOSR 1 (GS 28, GOS 28), rbet1 and rsec22. A more detailed analysis revealed two subcomplexes within this complex. One contains syntaxin 5 (mainly the shorter 35 kDa variant) and GS 28 whereas the other is composed of syntaxin 5 (35 and 42 kDa variant), membrin, rsec22 and rbet1. It has been suggested that theses complexes mediate the fusion of ER-derived vesicles with vesicular tubular clusters (VTC), and the fusion of VTCs to form the cis-Golgi compartment.