Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis.Tan JZA, Jang SE, Batallas-Borja A, Bhembre N, Chandra M, Zhang L, Guo H, Ringuet MT, Widagdo J, Collins BM, Anggono V, et al.
Cell reports (2023) 4212: 113460.
105 173 WB; tested species: rat
Rab GTPase-regulated phagosome-lysosome fusion is bypassed by micromolar calcium.Becker J, Schleinitz A, Hermsen C, Rappold S, Saftig P, Jeschke A, Haas A
Journal of cell science (2023) : .
105 173 WB; tested species: mouse
Neurotransmitter release progressively desynchronizes in induced human neurons during synapse maturation and aging.Uzay B, Houcek A, Ma ZZ, Konradi C, Monteggia LM, Kavalali ET
Cell reports (2023) 422: 112042.
105 173 WB; tested species: human
PACAP and acetylcholine cause distinct Ca2+ signals and secretory responses in chromaffin cells.Morales A, Mohan R, Chen X, Coffman BL, Bendahmane M, Watch L, West JL, Bakshi S, Traynor JR, Giovannucci DR, Kammermeier PJ, et al.
The Journal of general physiology (2023) 1552: .
105 173 WB; tested species: mouse
Synaptotagmins 1 and 7 in vesicle release from rods of mouse retina.Mesnard CS, Hays CL, Barta CL, Sladek AL, Grassmeyer JJ, Hinz KK, Quadros RM, Gurumurthy CB, Thoreson WB
Experimental eye research (2022) 225: 109279.
105 173 WB, IHC; KO verified; tested species: mouse
Synaptotagmins 1 and 7 play complementary roles in somatodendritic dopamine release.Hikima T, Witkovsky P, Khatri L, Chao M, Rice ME
The Journal of neuroscience : the official journal of the Society for Neuroscience (2022) : .
105 173 WB, IHC; KO verified; tested species: mouse
Synaptotagmin-7 places dense-core vesicles at the cell membrane to promote Munc13-2- and Ca2+-dependent priming.Tawfik B, Martins JS, Houy S, Imig C, Pinheiro PS, Wojcik SM, Brose N, Cooper BH, Sørensen JB
eLife (2021) 10: .
105 173 WB, ICC; KO verified; tested species: mouse
Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress.Chanaday NL, Nosyreva E, Shin OH, Zhang H, Aklan I, Atasoy D, Bezprozvanny I, Kavalali ET
Neuron (2021) 1098: 1314-1332.e5.
105 173 WB; tested species: mouse
Synaptotagmin-7-mediated activation of spontaneous NMDAR currents is disrupted in bipolar disorder susceptibility variants.Wang QW, Wang YH, Wang B, Chen Y, Lu SY, Yao J
PLoS biology (2021) 197: e3001323.
105 173 WB, ICC; KO verified; tested species: mouse
Synaptotagmin 1 oligomers clamp and regulate different modes of neurotransmitter release.Tagliatti E, Bello OD, Mendonça PRF, Kotzadimitriou D, Nicholson E, Coleman J, Timofeeva Y, Rothman JE, Krishnakumar SS, Volynski KE
Proceedings of the National Academy of Sciences of the United States of America (2020) : .
105 173 WB, ICC; KD verified; tested species: mouse
Distinct insulin granule subpopulations implicated in the secretory pathology of diabetes types 1 and 2.Kreutzberger AJB, Kiessling V, Doyle CA, Schenk N, Upchurch CM, Elmer-Dixon M, Ward AE, Preobraschenski J, Hussein SS, Tomaka W, Seelheim P, et al.
eLife (2020) 9: .
105 173 WB; tested species: rat
VAMP4 maintains a Ca2+-sensitive pool of spontaneously recycling synaptic vesicles.Lin PY, Chanaday NL, Horvath PM, Ramirez DMO, Monteggia LM, Kavalali ET
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : .
105 173 WB; tested species: rat
Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin.Gowrisankaran S, Houy S, Del Castillo JGP, Steubler V, Gelker M, Kroll J, Pinheiro PS, Schwitters D, Halbsgut N, Pechstein A, van Weering JRT, et al.
Nature communications (2020) 111: 1266.
105 173 WB, ICC; tested species: mouse
Synaptotagmin-7 enhances calcium-sensing of chromaffin cell granules and slows discharge of granule cargos.Bendahmane M, Chapman-Morales A, Kreutzberger AJB, Schenk NA, Mohan R, Bakshi S, Philippe J, Zhang S, Kiessling V, Tamm LK, Giovannucci DR, et al.
Journal of neurochemistry (2020) : e14986.
105 173 WB, ICC; KO verified; tested species: mouse
Synaptotagmin-7 is a key factor for bipolar-like behavioral abnormalities in mice.Shen W, Wang QW, Liu YN, Marchetto MC, Linker S, Lu SY, Chen Y, Liu C, Guo C, Xing Z, Shi W, et al.
Proceedings of the National Academy of Sciences of the United States of America (2020) : .
105 173 WB; tested species: human
Loss of voltage-gated proton channel Hv1 decreases insulin secretion and leads to hyperglycemia and glucose intolerance in mice.Pang H, Wang X, Zhao S, Xi W, Lv J, Qin J, Zhao Q, Che Y, Chen L, Li SJ
The Journal of biological chemistry (2020) : .
105 173 WB; tested species: mouse
In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties.Kreutzberger AJB, Kiessling V, Stroupe C, Liang B, Preobraschenski J, Ganzella M, Kreutzberger MAB, Nakamoto R, Jahn R, Castle JD, Tamm LK, et al.
Nature communications (2019) 101: 3904.
105 173 WB; tested species: rat
Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes.Zurawski Z, Thompson Gray AD, Brady LJ, Page B, Church E, Harris NA, Dohn MR, Yim YY, Hyde K, Mortlock DP, Jones CK, et al.
Science signaling (2019) 12569: .
105 173 WB; tested species: mouse
Synaptotagmin oligomerization is essential for calcium control of regulated exocytosis.Bello OD, Jouannot O, Chaudhuri A, Stroeva E, Coleman J, Volynski KE, Rothman JE, Krishnakumar SS
Proceedings of the National Academy of Sciences of the United States of America (2018) 11532: E7624-E7631.
105 173 WB; tested species: rat
Mutant Huntingtin Is Secreted via a Late Endosomal/Lysosomal Unconventional Secretory Pathway.Trajkovic K, Jeong H, Krainc D
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 3737: 9000-9012.
105 173 WB, ICC; tested species: mouse
Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs.Houy S, Groffen AJ, Ziomkiewicz I, Verhage M, Pinheiro PS, Sørensen JB
eLife (2017) 6: .
105 173 WB; KO verified; tested species: mouse
A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.Wolfes AC, Ahmed S, Awasthi A, Stahlberg MA, Rajput A, Magruder DS, Bonn S, Dean C
The Journal of general physiology (2017) 1491: 149-170.
105 173 ICC, WB
Injured astrocytes are repaired by Synaptotagmin XI-regulated lysosome exocytosis.Sreetama SC, Takano T, Nedergaard M, Simon SM, Jaiswal JK
Cell death and differentiation (2016) 234: 596-607.
105 173 WB, ICC; tested species: mouse
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8.
105 173 WB, ICC, IHC; tested species: mouse,rat
Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes.Andersson SA, Olsson AH, Esguerra JL, Heimann E, Ladenvall C, Edlund A, Salehi A, Taneera J, Degerman E, Groop L, Ling C, et al.
Molecular and cellular endocrinology (2012) 3641-2: 36-45.
105 173 WB
Synaptotagmin-7 as a positive regulator of glucose-induced glucagon-like peptide-1 secretion in mice.Gustavsson N, Wang Y, Kang Y, Seah T, Chua S, Radda GK, Han W
Diabetologia (2011) 547: 1824-30.
105 173 WB, IHC
Sunday driver interacts with two distinct classes of axonal organelles.Abe N, Almenar-Queralt A, Lillo C, Shen Z, Lozach J, Briggs SP, Williams DS, Goldstein LS, Cavalli V
The Journal of biological chemistry (2009) 28450: 34628-39.
105 173 WB, IHC
Synaptotagmin VII splice variants alpha, beta, and delta are expressed in pancreatic beta-cells and regulate insulin exocytosis.Gauthier BR, Duhamel DL, Iezzi M, Theander S, Saltel F, Fukuda M, Wehrle-Haller B, Wollheim CB
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2008) 221: 194-206.
105 173 WB, ICC
Characterisation of insulin-producing cells differentiated from tonsil derived mesenchymal stem cells.Kim SY, Kim YR, Park WJ, Kim HS, Jung SC, Woo SY, Jo I, Ryu KH, Park JW
Differentiation; research in biological diversity () 901-3: 27-39.
105 173 WB