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Parvalbumin antibody - 195 011

Parvalbumin is calcium binding protein specific for a subpopulation of GABAergic interneurones
Mouse monoclonal purified IgG
Cat. No.: 195 011
Amount: 100 µg
Price: $415.00
Cat. No. 195 011 100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: yes (see remarks)
IP: yes
ICC: 1 : 500 gallery  
IHC: 1 : 500 up to 1 : 1000 gallery  
IHC-P: 1 : 500 gallery  
Clone 58E1
Subtype IgG1 (κ light chain)
Immunogen Full-length recombinant rat Parvalbumin (UniProt Id: P02625)
Reactivity Reacts with: rat (P02625), mouse (P32848).
No signal: zebrafish.
Other species not tested yet.
Matching control protein/peptide 195-0P
Remarks

WB: The rabbit polyclonal antiserum (cat. no. 195 002) is recommended for westernblotting. Due to its small size, a tricine gel should be used.

Data sheet 195_011.pdf

References for Parvalbumin - 195 011

Investigations on the Ability of the Insular Cortex to Process Peripheral Immunosuppression.
Bihorac J, Salem Y, Lückemann L, Schedlowski M, Doenlen R, Engler H, Mark MD, Dombrowski K, Spoida K, Hadamitzky M
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology (2024) 191: 40. 195 011 IHC; tested species: rat
Adolescent intermittent ethanol exposure decreases perineuronal nets in the hippocampus in a sex dependent manner: Modulation through pharmacological inhibition of RPTPβ/ζ.
Galán-Llario M, Gramage E, García-Guerra A, Torregrosa AB, Gasparyan A, Navarro D, Navarrete F, García-Gutiérrez MS, Manzanares J, Herradón G
Neuropharmacology (2024) 247: 109850. 195 011 IHC; tested species: mouse
Sexually dimorphic role for insular perineuronal nets in aversion-resistant alcohol consumption.
Martins de Carvalho L, Chen H, Sutter M, Lasek AW
Frontiers in psychiatry (2023) 14: 1122423. 195 011 IHC; tested species: mouse
An enriched environment ameliorates the reduction of parvalbumin-positive interneurons in the medial prefrontal cortex caused by maternal separation early in life.
Irie K, Ohta KI, Ujihara H, Araki C, Honda K, Suzuki S, Warita K, Otabi H, Kumei H, Nakamura S, Koyano K, et al.
Frontiers in neuroscience (2023) 17: 1308368. 195 011 IHC; tested species: mouse
The role of α-tubulin tyrosination in controlling the structure and function of hippocampal neurons.
Hosseini S, van Ham M, Erck C, Korte M, Michaelsen-Preusse K
Frontiers in molecular neuroscience (2022) 15: 931859. 195 011 IHC; tested species: mouse
Activity-dependent reconnection of adult-born dentate granule cells in a mouse model of frontotemporal dementia.
Terreros-Roncal J, Flor-García M, Moreno-Jiménez EP, Pallas-Bazarra N, Rábano A, Sah N, van Praag H, Giacomini D, Schinder AF, Ávila J, Llorens-Martín M, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 195 011 IHC; tested species: mouse
The transgenic mouse line Igsf9-eGFP allows targeted stimulation of inferior olive efferents.
Pätz C, Brachtendorf S, Eilers J
Journal of neuroscience methods (2018) 296: 84-92. 195 011 IHC; tested species: mouse
Isolated P/Q Calcium Channel Deletion in Layer VI Corticothalamic Neurons Generates Absence Epilepsy.
Bomben VC, Aiba I, Qian J, Mark MD, Herlitze S, Noebels JL
The Journal of neuroscience : the official journal of the Society for Neuroscience (2016) 362: 405-18. 195 011 IHC; tested species: mouse
Mechanisms of Functional Hypoconnectivity in the Medial Prefrontal Cortex of Mecp2 Null Mice.
Sceniak MP, Lang M, Enomoto AC, James Howell C, Hermes DJ, Katz DM
Cerebral cortex (New York, N.Y. : 1991) (2016) 265: 1938-1956. 195 011 IHC; tested species: mouse
Cat. No.: 195 011
Amount: 100 µg
Price: $415.00
Investigations on the Ability of the Insular Cortex to Process Peripheral Immunosuppression.
Bihorac J, Salem Y, Lückemann L, Schedlowski M, Doenlen R, Engler H, Mark MD, Dombrowski K, Spoida K, Hadamitzky M
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology (2024) 191: 40. 195 011 IHC; tested species: rat
Adolescent intermittent ethanol exposure decreases perineuronal nets in the hippocampus in a sex dependent manner: Modulation through pharmacological inhibition of RPTPβ/ζ.
Galán-Llario M, Gramage E, García-Guerra A, Torregrosa AB, Gasparyan A, Navarro D, Navarrete F, García-Gutiérrez MS, Manzanares J, Herradón G
Neuropharmacology (2024) 247: 109850. 195 011 IHC; tested species: mouse
Sexually dimorphic role for insular perineuronal nets in aversion-resistant alcohol consumption.
Martins de Carvalho L, Chen H, Sutter M, Lasek AW
Frontiers in psychiatry (2023) 14: 1122423. 195 011 IHC; tested species: mouse
An enriched environment ameliorates the reduction of parvalbumin-positive interneurons in the medial prefrontal cortex caused by maternal separation early in life.
Irie K, Ohta KI, Ujihara H, Araki C, Honda K, Suzuki S, Warita K, Otabi H, Kumei H, Nakamura S, Koyano K, et al.
Frontiers in neuroscience (2023) 17: 1308368. 195 011 IHC; tested species: mouse
The role of α-tubulin tyrosination in controlling the structure and function of hippocampal neurons.
Hosseini S, van Ham M, Erck C, Korte M, Michaelsen-Preusse K
Frontiers in molecular neuroscience (2022) 15: 931859. 195 011 IHC; tested species: mouse
Activity-dependent reconnection of adult-born dentate granule cells in a mouse model of frontotemporal dementia.
Terreros-Roncal J, Flor-García M, Moreno-Jiménez EP, Pallas-Bazarra N, Rábano A, Sah N, van Praag H, Giacomini D, Schinder AF, Ávila J, Llorens-Martín M, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 195 011 IHC; tested species: mouse
The transgenic mouse line Igsf9-eGFP allows targeted stimulation of inferior olive efferents.
Pätz C, Brachtendorf S, Eilers J
Journal of neuroscience methods (2018) 296: 84-92. 195 011 IHC; tested species: mouse
Isolated P/Q Calcium Channel Deletion in Layer VI Corticothalamic Neurons Generates Absence Epilepsy.
Bomben VC, Aiba I, Qian J, Mark MD, Herlitze S, Noebels JL
The Journal of neuroscience : the official journal of the Society for Neuroscience (2016) 362: 405-18. 195 011 IHC; tested species: mouse
Mechanisms of Functional Hypoconnectivity in the Medial Prefrontal Cortex of Mecp2 Null Mice.
Sceniak MP, Lang M, Enomoto AC, James Howell C, Hermes DJ, Katz DM
Cerebral cortex (New York, N.Y. : 1991) (2016) 265: 1938-1956. 195 011 IHC; tested species: mouse
Background

Parvalbumin is a small, acidic calcium binding protein and belongs to the family of EF hand proteins. The protein is found in skeletal muscle and the brain of vertebrates where it locates to a specific population of GABAergic interneurons. This subset of neurons may contribute to maintaining the balance between excitation and inhibition in the cortex and the hippocampus.