Cat. No.: 196 003
Amount: 50 µg
Price:
$455.00
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| Cat. No. 196 003 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Recombinant protein corresponding to AA 293 to 384 from mouse PACSIN1 (UniProt Id: Q61644) |
| Reactivity |
Reacts with: rat (Q9Z0W5), mouse (Q61644), human (Q9BY11), zebrafish. Other species not tested yet. |
| Specificity | K.D. validated PubMed: 30683896 |
| Matching control protein/peptide | 196-0P |
| Data sheet | 196_003.pdf |
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This protein has been described as PACSIN 1 (for PKC and CK2 substrate in neurons) and syndapin 1 (synaptic, dynamin-associated protein I). It is a multidomain phospho-protein that interacts via its SH3 domain with dynamin 1, synaptojanin, synapsin and N-WASP. Since N-WASP is an activator of the Arp2/3 complex, syndapin may link membrane trafficking and the actin cytoskeleton.
Up to now, 3 isoforms have been described. Syndapin 1 shows a neuronal, syndapin 3 a muscular and syndapin 2 an ubiquitous expression profile.