GluN2A/B peptide - 244-0P

GluN2A and B are subunits of ionotropic NMDA type glutamate receptors

control peptide

Cat. No.: 244-0P

Amount: 100 µg

Price: $105.00

Cat. No. 244-0P	100 µg peptide, lyophilized. For reconstitution add 100 µl H₂O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Control peptides should be stored at -20°C when still lyophilized!
Applications
Immunogen	Synthetic peptide corresponding to AA 1448 to 1464 from mouse GluN2A (UniProt Id: P35436)
Recommended dilution	Optimal concentrations should be determined by the end-user.
Matching antibodies	244 002, 244 003, 244 004
Remarks	This control peptide consists of the synthetic peptide (aa 1448-1464 of rat GluN 2A) that has been used for immunization. It has been tested in preadsorption experiments and blocks efficiently and specifically the corresponding signal in Western blots. The amount of peptide needed for efficient blocking depends on the titer and on the affinity of the antibody to the antigen.
Data sheet	244-0p.pdf

Cat. No.: 244-0P

Amount: 100 µg

Price: $105.00

Background

GluNs (NMDA-receptors) represent a class of glutamate receptors that are of central importance in synaptic plasticity. Multiple NMDA receptor subtypes exist: GluN1 and GluN2 A-D. GluN1 is the most important as it is required for activity. NMDA-receptors allow Ca²⁺ influx and are thought to trigger Ca²⁺ dependent postsynaptic processes involved in long term potentiation and depression.

1 ) Groc L et al., Proc. Natl. Acad. Sci. U.S.A. (2006)
2 ) Nagy GG et al., Eur. J. Neurosci. (2004)
3 ) Petralia RS et al., Eur. J. Neurosci. (2002)
4 ) Sans N et al., J. Neurosci. (2000)
5 ) Conti F et al., Cereb. Cortex (1999)
6 ) Petralia RS et al., J. Neurosci. (1994)
7 ) Monyer H et al., Science (1992)

Protocols

OTHER

Preadsorbtion

Other products for this target