Cat. No.: 310 203
Amount: 50 µg
Price:
$455.00
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| Cat. No. 310 203 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Synthetic peptide corresponding to AA 3 to 14 from human MLC-2V (UniProt Id: P10916) |
| Reactivity |
Reacts with: human (P10916). Other species not tested yet. |
| Specificity | Specific for MLC-2V, no cross-reactivity to MLC-2A. |
| Matching control protein/peptide | 310-2P |
| Data sheet | 310_203.pdf |
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During cardiogenesis two major isoforms of myosin light chain 2 are co-expressed in a tightly regulated manner. MLC-2V is only present in the ventricle while MLC-2A is exclusively expressed in the atrium. Knock out studies revealed that the 2A isoform cannot substitute for the 2V variant in the ventricular chamber.
Recently it has been demonstrated that embryonic and adult stem cells can be differentiated into cardiomyocytes which may generate suitable replacements for damaged heart tissue in the future.
These antibodies are useful tools to distinguish between ventricle and atrium specific cardiomyocytes.